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Lymphopenia - DOAJ

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Last Updated: 26 September 2022

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Severe Radiation-Induced Lymphopenia Attenuates the Benefit of Durvalumab After Concurrent Chemoradiotherapy for NSCLC

In samples obtained at the end of CCRT, absolute lymphocyte count nadir was established, defining sRIL as nadir ALC less than 0. 23 percent 109/L; nadir ALC less than 0. 23 109/L Cox proportional hazard modeling evaluated associations between clinical variables and survival, comparing clinical variables and survival. In both treatment groups, sRIL predicted lower PFS and OS. Durvalumab did not improve survival among patients with sRIL, but not improve survival. Conclusions: After CCRT's NSCLC's testing, Severe RIL sacrifices the longevity benefits of durvalumab. To increase the benefits of consolidation durvalumab, implementing steps to reduce RIL following CCRT may be warranted.

Source link: https://doi.org/10.1016/j.jtocrr.2022.100391


Variable Normalization of Naïve CD4+ Lymphopenia and Markers of Monocyte and T Cell Activation over the Course of Direct-Acting Anti-Viral Treatment of Chronic Hepatitis C Virus Infection

Chronic hepatitis C virus infection is correlated with nave CD4+ T cell lymphopenia and persistent/persistent elevation of cellular and soluble immune activation parameters, the latter is elevated in the context of HIV co-infection. However, we recently reported that increased peripheral cell death may be responsible for nau00efve CD4+ T cell loss, T cell activation, and soluble inflammatory mediators.

Source link: https://doi.org/10.3390/v14010050


A machine learning model for grade 4 lymphopenia prediction during pelvic radiotherapy in patients with cervical cancer

paraphrasedoutput:Methods is a website that publishes articles about cervical cancer patients treated with definitive pelvic RT u00b1 induction/concurrent chemotherapy. Using clinical and dosimetric data to predict grade 4 lymphopenia during pelvic RT in patients with cervical cancer patients treated with definitive pelvic RT. During RT, ALC lymphopenia was diagnosed as G4 absolute lymphocyte count nadir, which was also designated as G4 lymphopenia during RT, with a 0. 2 109 cells/L during RT, according to Common Terminology Criteria for Adverse Events v4. 03. paraphrasedoutput:ResultsThe prediction of G4 lymphopenia during pelvic RT was confirmed by 130 patients who were eligible, while 43 patients had G4 lymphopenia during RT was found by an Elastic-net logistic regression model.

Source link: https://doi.org/10.3389/fonc.2022.905222


Severe radiation-induced lymphopenia during postoperative radiotherapy or chemoradiotherapy has poor prognosis in patients with stage IIB-III after radical esophagectomy: A post hoc analysis of a randomized controlled trial

In the postoperative concurrent chemoradiotherapy group, Doses of 54 Gy in 27 fractions was delivered in the postoperative radiotherapy unit and 50. 4 Gy in 28 fractions mixed with chemotherapy was delivered in 27 fractions, along with chemotherapy. The baseline absolute lymphocyte count was similar between G1-3 and G4 patients, according to Baseline's absolute lymphocyte count. In group G4 lymphopenia, the 3-year DFS was much lower than that in group G1-3. ConclusionsG4 RIL had poor disease-free survival because of increased PTV exposure of thoracic marrow and heart. The results of clinical trials are required to verify the results. NCT0227913434: The identifier NCT0227913434. gov identifier NCT02279134. gov.

Source link: https://doi.org/10.3389/fonc.2022.936684


Lymphopenia in COVID-19: γδ T Cells-Based Therapeutic Opportunities

This mini-review summarizes the results on the role of u03b4 T cells in coronavirus disease 2019, giving an overview of the excellent anti-viral therapeutic activity of u03b3u03b4 T cells that have yet to be exploited in depth.

Source link: https://doi.org/10.3390/vaccines9060562


Splenic irradiation contributes to grade ≥ 3 lymphopenia after adjuvant chemoradiation for stomach cancer

We investigated the connection between the spleen radiation dose and the observed severity of lymphopenia, which could have a major effect on clinical outcomes. Patients with adjuvant CRT for gastric cancer between January 2015 and December 2020 were analyzed by a method. The splenic dose and percentage of splenic volume were determined by the standard splenic dose and percentage of splenic volume receiving at least u00d7 Gray. Conclusion: High splenic radiation doses can raise the risk of severe post-CRT lymphopenia, an independent predictor of reduced OS and greater risks of recurrence and infections in gastric cancer patients receiving adjuvant CRT.

Source link: https://doi.org/10.1016/j.ctro.2022.07.007

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions