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Lymph Nodes - PubMed

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Last Updated: 26 September 2022

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Microenvironment components and spatially resolved single-cell transcriptome atlas of breast cancer metastatic axillary lymph nodes.

The lymph node metastasis of breast cancer has drawn major interest as an early warning of clinical deterioration. Many studies have described the characteristics of metastatic breast cancer cells, but no evidence has been published, but the effect of breast cancer cells on lymph nodes and spatial transcriptome atlas remains unclear. This report is the first to integrate scRNA-seq and spatial transcriptomics in the tumor microenvironment of axillary lymph nodes, providing a systematic pathway to research breast cancer lymph nodes metastasis.

Source link: https://doi.org/10.3724/abbs.2022131


Disseminated cancer cells detected by immunocytology in lymph nodes of NSCLC patients are highly prognostic and undergo parallel molecular evolution.

We investigated lymph node IC in non-small cell lung cancer here. More patients were found not surviving by lymphatic tumor spread by IC alone, consistent with the theory of skip metastasis. In multivariable analysis of prognosis, a combined lymph node status of IC and complete HP on a larger cohort of patients outperforms all risk factors. In addition, isolation of DCCs and single-cell molecular characterization revealed that LN-DCCs are different from primary tumours in terms of copy number variations, selected mutations, and other important changes are present during colony formation within LNs. We conclude that LN-IC in NSCLC patients may reduce total workload while still improving diagnostic accuracy, and that molecular analysis of lymphatically distributed cancer cells may be helpful in the selection and development of novel systemic therapies.

Source link: https://doi.org/10.1002/path.5996


Understanding COVID Vaccination and Its Implication in Cancer Patients' Imaging of Lymph Nodes by PET-CT.

Methods: 25 cancer patients with 18F-FDG PET-CT findings and a history of COVID-1921-212021 to December 2021 were retrospectively reviewed to determine lymph nodes related to the time period from COVID vaccination. All patients had one or two adenopathies localized in the ipsilateral axilla, ipsilateral cervical region, ipsilateral retropectoral, and pulmonary hilum. SUVmax was shown by an indirect correlation between the vaccination and the PET CT time period between the vaccination and the PET CT. Patients receiving the Moderna mRNA-1273 vaccine versus BNT162b2 B2 mRNA Pfizer vaccine showed no significant difference in the SUVmax value, according to the authors.

Source link: https://doi.org/10.3390/diagnostics12092163


Swollen inguinal lymph nodes with low fever and night sweat: diagnosis and treatment of case of cat-scratch disease lymphadenitis with sinus formation.

For 20 days, a 52-year-old woman complained of inguinal lymph node enlargement, low fever, and night sweats. Multiple ulcers in the affected area and sinus formation were accompanied by multiple ulcers. According to the Sanford Guide to Antimicrobial Therapy 2020, Azithromycin was administered in tandem with wound repair and partial resection of inguinal lymph nodes. In all, lymphadenitis related to B. henselae infection is difficult to detect.

Source link: https://doi.org/10.1016/j.heliyon.2022.e10448


Thyroid tissue in cervical lymph nodes, not always malignant.

Distinguishing malignant from benign thyroid tissue in cervical lymph nodes can be difficult, but it is also important for therapy and can have legal implications. Patients with incidentally discovered thyroid tissue in cervical lymph nodes during thyroid surgery were retrospectively identified. Two patients with thyroid tissue in cervical lymph nodes were identified. In the absence or presence of a primary thyroid tumor malignancy, benign thyroid tissue in cervical lymph nodes can be discovered.

Source link: https://doi.org/10.1002/ccr3.6261


Highly bright aggregation-induced emission nanodots for precise photoacoustic/NIR-II fluorescence imaging-guided resection of neuroendocrine neoplasms and sentinel lymph nodes.

owing to the excellent spatial resolution and signal-to-noise ratio, the dual-modality imaging technique of photoacoustic imaging/the second near-infrared window fluorescence imaging method holds a lot of promise for the detection of tumor tissues and sentinel lymph nodes. For the first time, PAI/NIR-III FI was applied to the diagnosis and treatment of neuroendocrine neoplasms and their SLNs in Herein. This dual-modality imaging system could increase the detection of NENs and the certainty of intraoperative SLNs dissection, improve patient prognosis, and establish a new approach to precise treatment of NENs.

Source link: https://doi.org/10.1016/j.biomaterials.2022.121780


Contrast enhanced magneto-motive ultrasound in lymph nodes - modelling and pre-clinical imaging using magnetic microbubbles.

Given advances in MRI, the detection and classification of lymph nodes in rectal cancer remains difficult, especially when evaluating the response to neo-adjuvant therapy. We provide proof-of-concept of the novel technique Contrast-Enhanced Magneto-Motive Ultrasound's ability to retrieve data related to local perfusion and lymphatic drainage, as well as investigate tissue mechanical properties by magnetically induced tissue deformations. After bolus injection, improved ultrasound imaging on one wild type mouse detected lymphatic drainage of magnetic microbubbles. The presence of a magnetic contrast agent in the lymph node is shown by Preliminary CE-MMUS. The finite element analysis investigates how the magnetic force is transferred to movement of the solid, which is dependent on elasticity and bubble radius, resulting in an inverse relationship with displacement. Using contrast enhanced ultrasound imaging and magneto-motion, tissue mechanical properties could aid in the detection and characterisation of lymph nodes. Biological relevance - Robust detection and characterisation of lymph nodes can be aided by visualizing lymphatic drainage of magnetic microbubbles using contrast enhanced ultrasound and magneto-motion.

Source link: https://doi.org/10.1109/EMBC48229.2022.9871876

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions