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Background of this research The aim of this study was to determine the prevalence and risk factors of occult metastasis to superficial level VI, which is defined as the space anterior to the strap muscles, including the lymph nodes between the sternocleidomastoid and sternohyoid muscles and suprasternal space lymph nodes. Results Of the 129 patients, 62 had lymph nodes in the harvested specimens of superficial level VI, and the mean number of lymph nodes extracted was 1. 2 u00b1 1. 2.
Source link: https://europepmc.org/article/MED/36129318
Purpose: The linguistic lymph nodes in oral cavity squamous cell cancer have been shown to greatly reduce locoregional control and survival. Leaving notes: One of the key conditions for improving the detection and treatment of LLN lesions may be the development and implementation of a single anatomic topographic classification of LLN subgroups.
Source link: https://europepmc.org/article/PPR/PPR546282
Tron-draining LNs are usually the first site of tumor metastasis in lung cancer, according to paraphrasedoutput. The connection between TDLN status and the response of primary tumor beds to immune checkpoint inhibitors in lung cancer patients is largely unknown. Methods We characterized and compared the radiological, metabolic, and pathologic responses from primary tumor beds and paired TDLNs from 68 lung cancer patients who underwent neoadjuvant ICIs plus surgery. Additional TDLNs and primary lung tumor beds were investigated separately, as well as paired TDLNs. With pCR/MPR but not their TDLNs counterparts, Neoadjuvant ICIs therapy reduced 18F-FDG-reflected metabolic activity in the primary tumor beds with pCR/MPR but not their TDLNs counterparts. Interpretation TDLNs under ICIs therapy's treatment's first clinically relevant study demonstrating unique reaction patterns of TDLNs in lung cancer and revealing the underappreciated relationship of TDLNs status to ICIs is the first scientifically based correlation of their matched primary tumors to ICIs in lung cancer.
Source link: https://europepmc.org/article/MED/36116212
Background Proton beam therapy penetrates tumor tissues in a large dose. However, proton beam therapy has only been used to treat recurrent endometrial cancer in a few cases; therefore, its benefits remain uncertain. Case description We herein present a case of a recurrence of endometrial cancer in the paraphrad gland nodes in a 59-year-old postmenopausal woman whose proton beam therapy had almost eradicated a 65% occurrence of endometrial cancer in the paramedic lymph nodes. Pron beam therapy was administered instead of surgery or conventional photon beam therapy, due to the risks involved with left kidney resection due to the scarcity of the tumor and left renal artery. Proton beam therapy is a potentially safe method for the treatment of recurrent endometrial cancer, where the tumor site limits surgical intervention and the use of conventional photon beam therapy.
Source link: https://europepmc.org/article/MED/36104694
Here, we modeled MeV infection in human tonsil explants by using a clinical strain of MeV that promotes GFP. Although T cells were the most common cell type in the lymphoid explants, B cells were the most prevalent infected population. The preferential infection of B cells was associated with elevated CD150 levels, according to a Flow cytometry analysis. We found that although germinal center B cells made up the largest population of infected B cells, there were no variations in susceptibility to MeV among individual B cell subsets. Among CD3+ T cells, infection in both the CD4+ and CD8+ compartments showed a preference for antigen experienced subsets and away from naive cells, consistent with relative CD150 expression. Both T and B cells were found to be highly affected by the potent induction of interferon gene expression in both T and B cells, according to a differential gene expression study. Author Summary Measles virus is a re-emerging pathogen with high incidences in children. Immunological amnesia is a risky disease triggered by MeV infection of lymphocytes. B cell lineages had a preferential infection among B cell lineages as opposed to T cell lineages, and memory cells in T cells are the most susceptible areas of infection in comparison to nau00eff counterparts, according to further immunophenotyping. Our data together, help define disease progression in lymph nodes and identify cellular susceptibilities to MeV infection, which may be important in the development of antivirals for MeV.
Source link: https://europepmc.org/article/PPR/PPR543609
Following machine-learning techniques, the aim was to investigate the potential of MRI radiomic analysis to determine oropharyngeal and non-oropharyngeal origins of cervical metastatic lymph nodes in p16-negative patients. Methods: A retrospectively reviewed a total of 150 patients with cervical metastatic LNs diagnosed with p16-negative head and neck squamous cell carcinoma. Result:: Five radiomic characteristics were significantly different between the p16-negative oropharyngeal and non-oropharyngeal groups. Both the logistic regression and neural network exhibited the highest prediction power among the four classifiers trained and applied for discrimination between oropharyngeal and non-oropharyngeal origins, with AUCs of 0. 87 and 0. 74 respectively in the preparation and validation cohorts. Conclusion: Radiomics and machine-learning diagnostic software with MRI results can help distinguish between oropharyngeal and non-oropharyngeal origins in p16-negative patients with cervical metastatic LNs.
Source link: https://europepmc.org/article/PPR/PPR543286
Purpose The exactness of lymph node dissection in robotic surgery for lung cancer remains disputed. We compared the reliability of LN dissection in robot-assisted thoracic surgery vs. video-assisted thoracic surgery. We compared the numbers of all LNs and mediastinal LNs dissected, the time required for LN dissection, injuries, and upstaging rates of the N factor among the two groups, based on their estimates. In RATS, the time needed for lymph node dissection was also longer.
Source link: https://europepmc.org/article/MED/36083513
Background The dearth of uniformly defined lymph node station in lung cancer radiotherapy leads to non-standard clinical target volume contouring, particularly in patients with large lump gross target volume lymph nodes. Based on the International Association for the Study of Lung Cancer's lymph node map, this report establishes lymph node boundaries in radiotherapy for lung cancer and automatically contours lymph node stations. The mean 3D Dice similarity coefficient values of DiUNEt in most lymph node stations were greater than 0. 7 percent, although 98. 87% of the lymph node station slices were accepted. Conclusions This is the first study to introduce a system that automatically contours lymph node regions station by station based on the IASLC lymph node map with bulky lump GTVnd.
Source link: https://europepmc.org/article/MED/36085253
Objectives This report was designed to determine if axillary lymph node dissection could be avoided in patients with 1-2 positive sentinel lymph nodes who underwent total mastectomy. Methods Consecutive breast cancer patients with 1-2 positive SLNs were retrospectively reviewed from a multi-institutional database. Patients were divided into a sentinel lymph node biopsy group and an ALND group. In 1-2 positive SLNs patients, a new meta-analysis revealed the connection of axillary surgery and disease-free survival or overall longevity in 13 out of 4733 relative studies. No difference between SLNB and ALND groups was shown in adjusted DFS or OS between the two groups, according to a Pooled review. In four studies with patients only receiving BCS, or in three studies with patients only receiving TM, the survival benefit of ALND remained non-significant after restricting the study to four studies. With 1-2 positive SLNs treated with TM, it does not influence adjuvant chemotherapy administration or disease progression in breast cancer patients.
Source link: https://europepmc.org/article/MED/36076127
Background and controversy The treatment of lateral pelvic lymph nodes for rectal cancer is a controversial and controversial topic. The aim of this research was to investigate the correlation between lateral pelvic lymph node features on magnetic resonance imaging and positron emission tomography with oncologic outcomes in patients with rectal cancer. Methods An retrospective review of 284 patients with primary locally advanced rectal cancer treated with neoadjuvant therapy and surgical resection with curative intent between January 2003 and Dec 2018 was conducted. Imaging studies were re-analysed by radiologists blinded to clinical findings from this study population, a small group of 77 patients with abnormal lateral pelvic lymph nodes on preoperative imaging. Conclusions A lateral pelvic lymph node short of the axis of sizing was a significant predictor of poor three-year local recurrence free survival in the lateral pelvic lymph node short axis.
Source link: https://europepmc.org/article/MED/36074654
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