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Lyme Disease - PLOS

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Last Updated: 15 November 2022

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Healthcare claims-based Lyme disease case-finding algorithms in the United States: A systematic literature review

Background and objective: Lyme disease is the fifth most commonly reported notifiable infectious disease in the United States, with approximately 35,000 cases reported in 2019 by public health surveillance. To determine the burden of LD using healthcare claims data and the effectiveness of interventions for LD prevention and treatment, it is important to use validated well-performing LD case-finding methods. LD algorithms used with U. S. healthcare claims data and their validation status were determined by a systematic literature review. Four studies used LD diagnosis codes and antibiotic dispensing data alone, four studies used LD diagnosis codes and antibiotic dispensing data, while the remaining four studies used serologic test order codes in combination with LD diagnosis codes and antibiotic records. Only one of the studies that reported algorithm results: sensitivity 50% and positive predictive value 5%, with exceptions based on Lyme disease diagnosis code only.

Source link: https://doi.org/10.1371/journal.pone.0276299


A multimodal neuroimaging study of brain abnormalities and clinical correlates in post treatment Lyme disease

Lyme disease is the most common vector-borne infectious disease in the United States. Lyme disease is a disease that affects 10 to 20 percent of patients in which signs persist despite antibiotic therapy. During a functional MRI, this research administered a working memory test to a carefully selected group of 12 patients with well-defined PTLD and 18 healthy controls. A subset of 12 controls and all 12 PTLD participants were also included in diffusion tensor imaging to determine white matter integrity. Patients with PTLD responded more slowly, but not necessarily more accurately than controls, on the working memory test. Many frontal lobe areas in which increased axial diffusivity in the patients with PTLD coincided with longer illness were found in the patients with PTLD. High axial diffusivity may refer to white matter repair and recovery over time rather than pathology, rather than pathology, and cognition seems to be continuously affected throughout the recovery process.

Source link: https://doi.org/10.1371/journal.pone.0271425

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions