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Borrelia burgdorferi bacteria-causing Lyme disease is an infectious disease caused by Borrelia burgdorferi bacteria. A rapidly growing red rash on the skin at the site of the tick bite is a hallmark of early localized infection and Lyme disease, and it is often bull's-eye shaped. As the bacteria is spread throughout the body in the bloodstream, the early disseminated stage of Lyme disease occurs. This stage comes just weeks after the tick bite. Lyme disease's late disseminated stage can occur months to years after the tick bite. Individuals with post-treatment Lyme disease syndrome experience extreme exhaustion, muscle and joint pain, headache, or difficulty concentrating even after antibiotic therapy, when there are no evidence of the bacteria in the body. People have joint pain and swelling after successful antibiotic therapy for months or years.
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