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Lyme Disease - Europe PMC

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Last Updated: 15 May 2022

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Incidence and associated factors of cetuximab-induced hypersensitivity infusion reactions in 1392 cancer patients treated in four French areas: A possible association with Lyme disease?

Patients with cessimab infusion from January 2010 to June 2019 in four French regions with different Lyme disease incidence rates. This CI-IR incidence in the Lyme disease high-risk area was much higher than in other regions. CI-IRs were significantly higher in the high-risk region in the head and neck squamous cell carcinoma patient subgroup. Conclusion: Patients in the French region with the highest incidence of Lyme disease are at a higher risk of CI-IRs, according to this report.

Source link: https://europepmc.org/article/PPR/PPR490325


Development of recombinant monoclonal antibodies targeting conserved VlsE epitopes in Lyme disease pathogens

VlsE is an outer surface protein of the Lyme disease pathogen and a common diagnostic biomarker of Lyme disease. However, VlsE's high sequence regularity makes it difficult to produce consistent VlsE-based diagnostics and therapeutics. We first measured amino-acid sequence variability encoded by the vls genes from thirteen B. burgdorferi genomes by evolutionary analysis. We tested the antigenicity of these five IR peptides using sera from three mammalian host species, including human patients, the natural reservoir white-footed mouse, and VlsE-immunized New Zealand rabbits. The IR4 and IR6 peptides became the most antigenic and reacted well with both the human and rabbit sera, according to both the human and rabbit sera, though most IR peptides responded poorly with sera from natural hosts. These IR-specific rMAbs are promising diagnostic and theragnostic agents for rapid detection of Lyme disease pathogens regardless of strain heterogeneity due to their specific recognition of the conserved epitopes on VlsE.

Source link: https://europepmc.org/article/PPR/PPR489415


Cat Ownership and Rural Residence Are Associated with Lyme Disease Prevalence in the Northeastern United States.

Lyme disease is the most common vector-borne disease in the United States. To compare LD patients and non-LD counterparts as well as elucidate LD-related factors, we used an online questionnaire. Compared to those living in a metropolitan area, rural areas had a 36 percent rise in the likelihood of LD. Participants with Lyme Disease were more likely to wear insect repellant and perform tick checks. Although the reasons behind the adoption of LD prevention techniques are unclear, fear of LD harm does motivate their use.

Source link: https://europepmc.org/article/MED/35565004


Scleritis in Lyme Disease.

The percentage of new onset scleritis in the database was calculated after identifying all new-onset cases of scleritis in the database. According to the Centers for Disease Control, the number of Lyme disease cases with scleritis was estimated using the number of cases in the Baltimore metropolitan area. After querying other major eye centers in the area for any cases of Lyme disease scleritis, none were found, and the incidence of Lyme disease scleritis was estimated using published U. S. Census results for the Greater Baltimore metropolitan area, the incidence of Lyme disease scleritis was estimated. Scleritis accounted for 0. 6% of all cases of scleritis, and 0. 05 percent of patients with Lyme disease scleritis had scleritis. According to statistics, Lyme scleritis prevalence in the region was 0. 2 per 1,000,000 people per year, while Lyme scleritis incidence in the area was 3 per 10,000 people per year.

Source link: https://europepmc.org/article/MED/35513033


In Vitro Evaluation Of The Antimicrobial Activity Of Monolaurin Against Borrelia burgdorferi,The Lyme Disease Spirochete.

We investigated the antimicrobial activity of monolaurin against Borrelia burgdorferi, the Lyme disease spirochete, in this research. The B. burgdorfer has adaptive mechanisms that allow it to escape detection by host immune response. Novel therapeutic modalities to solve Lyme disease related disorders are increasingly being sought. We suspect that monolaurin will reduce the profitability of B. burgdorferi in a dose response manner. B. burgdorferistrain B31 was raised under serially diluted monolaurin conditions. Resazurin assay was used to determine bacterial viability and determine an approximate minimum inhibitory concentration. RESULTS: We found a MIC value of monolaurin against B. burgdorferi that varied between 75 g/mL and 150 g/mL. The antimicrobial range from 75 g/mL to 125 g/mL was narrowed by the live-dead assay. There was a trend among dead spirochetes with higher monolaurin concentrations that was statistically significant. B. burgdorferi, and our results point to the use of monolaurin as an antibacterial agent.

Source link: https://europepmc.org/article/MED/35567448


Persistent Symptoms, Lyme Disease, and Prior Trauma.

Anxiety can be determined by traumatic events leading to Lyme disease, according to a previous report. The results of a multi comparisons test revealed that a greater number of traumatic events were significantly related to greater symptom severity on the scales of mood, cognition, multisystem symptom burden, and functional status, but not on measures of pain and exhaustion.

Source link: https://europepmc.org/article/MED/35413029


Efficacy of Short-Term High Dose Pulsed Dapsone Combination Therapy in the Treatment of Chronic Lyme Disease/Post-Treatment Lyme Disease Syndrome (PTLDS) and Associated Co-infections: A Report of Three Cases and Literature Review

Despite early antibiotics, widespread Lyme disease and related co-infections are on the rise worldwide, and approximately 20% of individuals develop chronic Lyme disease and its related co-infections, and around 20% of people have chronic Lyme disease and related co-infections are increasing worldwide. Despite early antibiotics, nearly 20% of people have chronic Lyme disease and related co-infections are increasing worldwide, and approximately 20% of individuals experience persistent Lyme disease and related co-infections are increasing globally, and Patients with symptoms remission in half of patients for one year or longer have been symptom remission in about half of patients, with published culture reports revealing that higher doses of dapsone proves equitability against Borrelia burgdorferi's resistant biofilm forms. In random, controlled clinical trials, randomized, controlled clinical trials may have shown that high dose pulsed dapsone combination therapy may be a new therapeutic approach for the treatment of resistant CLD/PTLDs.

Source link: https://europepmc.org/article/PPR/PPR488942


Borreliella burgdorferi Antimicrobial-Tolerant Persistence in Lyme Disease and Posttreatment Lyme Disease Syndromes.

Lyme disease, a tick-transmitted Borreliella burgdorferi infection, causes by tick-transmitted Borreliella burgdorferi, is expected to have at least 476,000 cases in the United States and many more around the world. Post-treatment Lyme disease patients in antibiotic-treated Lyme disease patients have post-treatment Lyme disease syndrome, a medical disorder whose etiology and pathogenesis are uncertain. After the recently approved antimicrobial therapy, B. burgdorferi becomes tolerant to antimicrobials and persistent in vitro in response to antimicrobials and experimental studies in mice and nonhuman primates, as well as clinical findings, have shown that borrelial tolerance/persistence in vitro in mice and nonhuman primates.

Source link: https://europepmc.org/article/MED/35467428


Behavioral risk factors associated with reported tick exposure in a Lyme disease high incidence region in Canada.

Education on tick bite prevention is the keystay of public health intervention, and to combat these emerging threats. In a high incidence area of tick bites and LD, a pilot study was carried out to determine the link between preventive behaviors toward tick bites and LD, as well as reported tick exposure in a Canadian, LD high incidence area. Conclusions 3. 2 to 21. 9 percent was the first year of a reported tick borne disease epidemic in the United States. PEP therapy was administered to a minority of respondents who needed medical attention after a tick bite. According to reported tick exposure in multivariable models, tick testing, time spent outdoors, and living in a subregion with a higher public health LD risk level were all associated with reported tick exposure. Conclusions This report shows that in an area where the LD risk is among the highest in Canada, there is a lack of preventive activities against tick bites.

Source link: https://europepmc.org/article/MED/35459149

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions