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Lyme Disease - DOAJ

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Last Updated: 15 May 2022

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Incidence of Lyme disease in the United Kingdom and association with fatigue: A population-based, historical cohort study.

Background Estimations of Lyme disease prevalence in the United Kingdom vary. Methods and findings A population-based longitudinal cohort study was conducted on patients treated in general health services contributing to IQVIA Medical Research Data, 2,130 patients with Lyme disease diagnosed between 2000 and 2018 were matched by age, sex, and general practice, followed by a median time of 3 years and 8 months. The average incidence rate of Lyme disease in the United Kingdom increased from 2. 55 in 2000 to 9. 33 in 2018, up from 9. 55 in 2000 to 9. 33 in 2018. Conclusions The most important data from UK primary care studies showed that Lyme disease was associated with subsequent exhaustion and ME/CFS. Although Albeit slowed in the long run, these effects persisted beyond six months, meaning that patients and healthcare professionals should remain vigilant to fatigue symptoms months to years after Lyme disease diagnosis.

Source link: https://doi.org/10.1371/journal.pone.0265765


Cat Ownership and Rural Residence Are Associated with Lyme Disease Prevalence in the Northeastern United States

Lyme disease is the most common vector-borne disease in the United States. To compare LD patients and non-LD counterparts and elucidate risk factors associated with LD, we used an online questionnaire. Compared to those living in a urban area, residing in rural areas was associated with a 36 percent rise in the likelihood of LD. Participants who reported knowing someone with Lyme Disease were more likely to wear insect repellant and perform tick checking. Although the usage of LD prevention tools are not well understood, fears regarding LD risk motivates their use.

Source link: https://doi.org/10.3390/ijerph19095618


Predictive Model of Lyme Disease Epidemic Process Using Machine Learning Approach

Lyme disease is Eastern Europe's most common tick-borne disease. A retrospective review of the Lyme disease infections reported in the Kharkiv region, East Ukraine, between 2010 and 2017. To learn the Lyme disease epidemic process, a multilayered neural network was used, and the backpropagation algorithm or generalized delta rule was used. A software package for predicting the Lyme disease prevalence on the basis of machine learning has been developed.

Source link: https://doi.org/10.3390/app12094282


Potential Regulatory Role in Mammalian Host Adaptation for a Small Intergenic Region of Lp17 in the Lyme Disease Spirochete

Borrelia burgdorferi, the bacterial agent of Lyme disease, depends on a complex genetic network to move between the diverse Ixodes tick vector and mammalian host environments. A B. burgdorferi mutant lacking a transcriptionally active intergenic region of lp17 showed attenuated murine tissue colonization and pathogenesis due to altered expression of multiple antigens. We recently reported that a B. burgdorferi mutant lacking a transcriptionally active intergenic region of lp17. In cis complemented strains containing mutations aimed at preventing future protein translation were capable of complete tissue colonization, indicating that the functional product encoded by the intergenic region is not a protein as previously predicted. In both immunocompetent "and immunodeficient mice, in transcomplementation of the intergenic region resulted in increased transcription of the sequence relative to wild type, and it was found to completely eliminate infectivity in both immunocompetent "and immunodeficient mice. " During murine infection, translation of the intergenic region by wild-type B. burgdorferi was found to be high during murine infection relative to in vitro culture.

Source link: https://doi.org/10.3389/fcimb.2022.892220


Behavioral risk factors associated with reported tick exposure in a Lyme disease high incidence region in Canada

Education on the prevention of tick bites remains the mainstay of public health intervention, despite these emerging threats. In a high incidence area of tick bites and LD in a Canadian, LD high incidence area, the aim of this study was to determine the introduction of preventive behaviors toward tick bites and LD as well as analyze the relationship between behavioral risk factors and reported tick exposure. A PEP treatment was given to a minority of respondents who needed medical care following a tick bite. Performing tick checks, time spent outdoors, and living in a subregion with a higher public health LD risk level were all associated with reported tick exposure in multivariable models. Conclusions This report reveals that in an area where the LD risk is one of the highest in Canada, the low rate of adoption of preventive measures against tick bites is low.

Source link: https://doi.org/10.1186/s12889-022-13222-9


The glycerol-3-phosphate dehydrogenases GpsA and GlpD constitute the oxidoreductive metabolic linchpin for Lyme disease spirochete host infectivity and persistence in the tick.

The interconversion of glycerol-3-phosphate and dihydroxyacetone phosphate, catalyzed by GpsA and another glycerol-3-phosphate dehydrogenase, GlpD, has limited biosynthetic and metabolic capacity, contributing to central carbohydrate and lipid metabolism; the linchpin linking central carbohydrate and lipid metabolism is limited; phosphate and dihydroxyacetone phosphate dehydrogly phosphate Similarly, both glycerol and N-acetylglucosamine were bactericidal to B. burgdorferi in a GlpD-dependent manner during in vitro nutrient stress. This research is also the first to establish a suppressor mutation in B. burgdorferi: a glpD mutation restored the wild-type phenotype to the pleiotropic gpsA mutant, including murine infectivity by needle inoculation at high doses, survival under nutrient stress, morphological changes, and the metabolic imbalance of NADH and glycerol-3-phosphate. These results show that basic metabolic functions that are ineffective for in vitro growth can be vital for B. burgdorferi's vivo infectivity and may be useful therapeutic targets.

Source link: https://doi.org/10.1371/journal.ppat.1010385


Lyme Disease: A Role for Coenzyme Q10 Supplementation?

Following a bite from an infected tick, a bacterial infection ensued, resulting in a bacterial infection. Patients are often treated with antibiotics, but in cases where antibiotic therapy is postponed, or patients do not respond to antibiotic therapy, exhaustion can occur, as well as problems impacting the nervous system, cardiovascular system, and joints.

Source link: https://doi.org/10.3390/antiox11040667


Spatiotemporal trends and socioecological factors associated with Lyme disease in eastern Ontario, Canada from 2010–2017

We used estimated human Lyme disease case and tick surveillance data submitted by the public from 2010–2017 to determine trends in tick distribution, spatiotemporal clusters of infection, and socioeconomic risk factors for Lyme disease using a multivariable negative binomial regression model using a publicly available free tick surveillance database. We found significant variability in tick exposure patterns based on place of residence, with 65% of Lyme disease patients from Ottawa's city of Ottawa reporting tick exposures outside of their health unit of residence, compared to 86. 1%—98. 1% of patients from other, predominantly rural, health services reporting peri-domestic exposures. In eastern Ontario, we found eight spatiotemporal clusters of human Lyme disease prevalence, overlapping with three clusters of Borrelia burgdorferi-infected ticks. Our research reveals that there are regional variations in tick exposure patterns in eastern Ontario, and that various socioeconomic and socioeconomic causes may play a role in Lyme disease risk in this region.

Source link: https://doi.org/10.1186/s12889-022-13167-z


Inclusion of environmentally themed search terms improves Elastic net regression nowcasts of regional Lyme disease rates.

Lyme disease is the most common vector-borne disease in the United States, according to the most commonly reported mosquito-borne disease. When an infected nymph Ixodid tick takes a blood meal, human infections most commonly occur in the spring and summer months. These lags in reporting have made it impossible for public health departments to assess and plan for the new burden of Lyme disease. 1. We produced two sets of elastic net models for five regions of the United States: 1. We created two sets of elastic net models for five regions of the country: 1. Using the full-term list, four of the United States' five regions were highly accurate, with accuracy improved by 1. 33-fold, while decreasing error by 0. 5 percent over straight models based on disease symptom and vector terms alone. These models can be used to help local and state public health departments accurately monitor Lyme disease prevalence in the midst of reporting delays from federal health reporting agencies during times of reporting lag.

Source link: https://doi.org/10.1371/journal.pone.0251165

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions