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Lung Cancer - Springer Nature

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Last Updated: 15 June 2022

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A novel RET fusion in non-small cell lung cancer identified by next-generation sequencing: a case report

Transfection gene fusion is one of the most common oncogenic variants in non-small cell lung cancers. However, only a handful of RET fusion cases have partner intergenic-breakpoint fusions, in which the partner breakpoint localizes to intergenic regions. "In a rare case of RET fusion in the cancerous tissue in which an intergenic fragment upstream multiple inositol-polyphosphate phosphate 1 gene was fused with the tyrosine kinase gene in RET was fused with the tyrosine kinase domain in RET," a novel form of RET fusion was identified in RET fusion in a rare form of RET chon phosphate RET chond RET fusion in the reti chond RET chon phosphate kinase phosphate kinase phosphate kinase phosphate kinase tyrositol-targete kinase phosphatase phosphatas.

Source link: https://doi.org/10.1007/s00432-022-03969-4


Immune checkpoints related-LncRNAs can identify different subtypes of lung cancer and predict immunotherapy and prognosis

"Background Non-small cell lung cancer is the most common form of lung cancer in the United States. " However, the survival rate of non-small cell lung cancer patients is still low. As important roles in prognostic value and immunotherapeutic response to non-small cell lung cancer, the immune checkpoint and long non-coding RNAs are emerging. In patients with Non-small cell lung cancer patients, it is crucial to identify LncRNAs associated with immune checkpoints. This risk model based on the immune checkpoint-based LncRNAs can be a useful clinical prediction for prognosis and immunotherapeutic responses in patients with NSCLC. "We conducted an integrative review of LncRNAs related to immune checkpoints, lymphocyte infiltration of the tumor, immunotherapy, and chemotherapy response" in determining the tumor microenvironment score, immune cell infiltration, and chemotherapy response.

Source link: https://doi.org/10.1007/s00432-022-03940-3


Baseline tumour size is an independent prognostic factor for overall survival in PD-L1 ≥ 50% non-small cell lung cancer patients treated with first-line pembrolizumab

"Background" has a story about "Advance non-small cell lung cancer with a PD-L1 tumor proportion score of u2265 percent can be treated with pembrolizumab alone. In NSCLC patients treated with pembrolizumab versus chemotherapy, we wanted to determine the effects of baseline tumor size on overall survival. Methods This retrospective, multicentre review included all patients with untreated advanced NSCLC who were receiving either pemolizumab or platinum-based chemotherapy. The impact of BTS on OS was the primary endpoint. BTS > 86 mm vs. NR for BTS > 18. 2 months [95% CI 12. 2], U2013 not reached] for BTS 86 mm versus NR for BTS 86 mm compared to NR for BTS 86 mm. In univariate and multivariate studies, the CT-group OS was not significantly different between low and high BTS patients, in univariate and multivariate analyses. BTS was an independent prognostic factor for OS in PD-L1-45 percent advanced NSCLC patients treated first-line with pedigolizumab after adjustment based on key clinical prognostic factors.

Source link: https://doi.org/10.1007/s00262-021-03108-x


Influence of social isolation and loneliness on the prognosis of advanced lung cancer patients: a prospective cohort study

"Purpose": The aim of this report was to investigate the effect of social isolation and loneliness on the overall health and death of patients with lung cancer at home. Methods This prospective cohort study was done in a Japanese tertiary hospital. This review included patients with pathologically diagnosed advanced lung cancer. According to their social stigma and loneliness, a total of 211 patients were registered and divided into two groups and further into quartiles, according to their socioeconomic vulnerability and loneliness levels. In the univariate analysis, the risk ratios of social isolation were 1. 65 and 1. 87, while 1. 40 in the multivariate analysis with complete case and multiple imputation was 1. 65 and 1. 87, respectively. In the multivariate analysis with multiple imputation, the odds ratio of death at home with social isolation was 3. 47. Conclusions Our report finds that social alienation may be related to overall health and death at home among patients with advanced lung cancer. ".

Source link: https://doi.org/10.1007/s00520-022-07026-1


Association between physical activity and patient-reported outcome measures in patients with lung cancer: a systematic review and meta-analysis

"Objective" is a broad term used to investigate the correlation between physical fitness and Health-Related Quality of Life as well as other Patient-Reported Outcome Measures in patients with lung cancer. The connection of PA levels and Health-Related Quality of Life and/or other PROMs was included in the study, as well as other PROMs. Using the Johanna Briggs Institute Critical Appraisal Tools, the risk of bias was determined. Moderate associations were found between PA and international HRQoL, as well as depression. In addition, small assocaitions were also recorded for exhaustion and dyspnoea. No significant associations were found for anxiety or sleep. Conclusions Although the majority of the studies contained some risk of bias, participating in regular PA appears to be linked to improved overall HRQoL, mood, and less symptom burden in patients with LC. ".

Source link: https://doi.org/10.1007/s11136-021-03053-3


The prognostic impact of mild and severe immune-related adverse events in non-small cell lung cancer treated with immune checkpoint inhibitors: a multicenter retrospective study

"Patients treated with immune checkpoint inhibitors often have unique immune-related adverse events, and the most recent reports found a connection between irAEs and improved outcomes in patients with ICI treatment for advanced non-small cell lung cancer patients. We retrospectively reviewed a multicenter study of advanced NSCLC patients treated with ICI monotherapy. For all patients treated with ICIs, the hazard-free survival of the 3. 2 months was expected. Patients with irAEs had a better prognosis than those without, and mild irAEs were associated with the best prognosis. We further explored the similarities between patients with irAEs occurring at 3 or 6 weeks, finding that the earlier the occurrence of mild irAEs, the better the prognosis; however, the opposite was true for severe irAEs. In summary, patients with early-acting mild irAEs had improved clinical results, while those with early irAEs had poorer clinical outcomes. ".

Source link: https://doi.org/10.1007/s00262-021-03115-y


The real-world efficacy and safety of anlotinib in advanced non-small cell lung cancer

"Purpose Anlotinib is an anti-angiogenetic multi-targeted tyrosine kinase inhibitor," says Angoo. In advanced non-small cell lung cancer in the real world, this research sought to determine the efficacy and safety of anlotinib. Patients with aNSCLC receiving anlotinib were enrolled in two cohorts. The PFS was 8. 0 months in the mixed cohort and 4. 3 months in the monotherapy group, respectively, in the previously treated cohort. Hypertension, exhaustion, hand-foot syndrome, diarrhea, proteinuria, and mucositis oral were among the ar-AEs in the monotherapy and combination groups' hypertension, fatigue, hand-foot syndrome, hand-foot syndrome, hand-foot syndrome, diarrhea, proteinuria, and mucositis oral. Anlotinib monotherapy, aNSCLC's first-line setting, has a promising success. Trial registration is accepted retrospectively by ISRCTN Registry on January 26th, 2021, and the Chinese Clinical Trial Register on April 4th, 2020. ".

Source link: https://doi.org/10.1007/s00432-021-03752-x


Identification of the function of γδ1 T cells in the lung cancer microenvironments

"Methods Tils cell cultures were collected, some of which were prepared tissue sections, while others were isolated and amplified into TILs cells, and then cloned and amplified," the narrator said. Immunomodulatory effects of u03b3 u03b41 T cells on naive and effector CD4+ T cells were established by immunohistochemistry, flow cytometry, CCK8, ELISA, and transwell culture. T cells with a high percentage of u03b3u03b41 T cells were discovered in lung cancer tissues. By effector CD4+ T cells, the naive CD4+ T cells' genetic supernatants of u03b3-b41 T cells could block the proliferation of naive CD4+ T cells and reduce the secretion level of IL-2. Conclusion u03b3-U3b41 T cells play a negative immunoregulation role in lung cancer microenvironments, and have shown immunosuppressive effects on proliferation and cytokine release of naive CD4+ T cells and effector CD4+ T cells," according to the poster "u03b3 u03b41 T cells and effector CD4+ T cells.

Source link: https://doi.org/10.1007/s12094-022-02780-4


Metformin inhibits human non-small cell lung cancer by regulating AMPK–CEBPB–PDL1 signaling pathway

"However, its effects on non-small cell lung cancer remain unclear. " We demonstrated that metformin could inhibit the cell proliferation of A549 and H1299 cells. Protein expression of the isoforms CEBPB-LAP, and CEBPB-LIP was clearly upregulated, according to Western blotting, and the LIP/LAP ratio was raised. PDL1 was significantly upregulated in A549-CEBP-LAP cells and substantially downregulated in A549-CEBPB-LIP cells relative to CEBPB-NC cells, and significantly reduced in A549-CEBPB-LIP cells, according to CEBPB-NC cells. CEBPB-LAP overexpression, according to a Dual-luciferase reporter gene assay, could lead to transcription of PDL1 and CEBPB-LIP overexpression, which could impede the process. The changes in CEBPB isoforms affected NSCLC cells' behavior, according to functional assays. Metformin, according to Western blotting, could modulate the function of NSCLC cells by AMPK+u2013PDL1 signaling. Tumor formation was greatly reduced by metformin, according to animal experiments, and atezolizumab and metformin had a synergistic effect on tumor formation. ".

Source link: https://doi.org/10.1007/s00262-021-03116-x

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions