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Lung Cancer - Europe PMC

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Last Updated: 15 June 2022

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Cardamonin suppressed the migration, invasion, epithelial mesenchymal transition (EMT) and lung metastasis of colorectal cancer cells by down-regulating ADRB2 expression.

"Context Cardamonin can stop cell growth in colorectal cancer, a common digestive disease. " Cell viability, migration, and invasion were determined by cell counting kit-8, wound healing, and transwell assays, respectively. ADRB2 was highly expressed in CRC tissues, as shown by the experiments. CDN's effect on CRC cells was hampered by ADRB2 overexpression by ADRB2 overexpression, but it was boosted by ADRB2's downregulation. Also, overexpression of CDN in metastatic lung nodules reversed the inhibitory effect of CDN on metastatic lung nodules. CDN is a potential candidate for the treatment of metastatic CRC in clinical practice, according to the study and conclusions.

Source link: https://europepmc.org/article/MED/35645356


Optimized 2-methoxyestradiol invasomes fortified with apamin: a promising approach for suppression of A549 lung cancer cells.

"Certain anticancer drugs selectively attack cancer cell nucleus. " The INVA component quantities were optimized to produce spherical particles with the smallest size, that is, a diameter of 167. 8 nm, by using Design-Expert software. Unlike raw 2ME, 2ME-INVA-APA significantly reduced A549 cells and showed an IC 50 of 1. 15 % u00b1 0. 04 g/mL, which is lower than raw 2ME. Compared to those treated with plain formula or 2ME alone, a significant rise in cell death and necrosis was observed in A549 cells, with a significant rise in cell death and necrosis was observed among the A549 cells, according to those treated with plain formula or 2ME alone. This effect was demonstrated by increased Bax expression and reduced Bcl-2 expression, as well as mitochondrial membrane potential loss. In addition, the cell cycle analysis showed that 2ME-INVA-APA arrests the G2-M phase of the A549 cells was detected by the cell cycle. These results found that our optimized 2ME-INVA-APA could rapidly seep through the cell membrane and induce apoptosis in very small doses. ".

Source link: https://europepmc.org/article/MED/35612292


Treatment of malignant pleural effusion in non-small cell lung cancer with VEGF-directed therapy.

"Background Vascular endothelial growth factor is a vital regulator of malignant pleural edema in non-small-cell lung cancer. " Bevacizumab and apatinib are novel VEGF blockers that reduce lung cancer cell proliferation and pleural effusion. Methods In this research, we established Lewis lung cancer xenograft mouse models to compare the therapeutic effects of APA and BEV in combination with cisplatin against MPE. "GETTING MPE patients with MPE can prolong the survival time of mice, reduce the amount of MPE, reduce the ultrasound maximum of thoracic tumour tissue, down-regulate the content of VEGF and sVEGFR-2 in serum and pleural fluid, and promote tumor cell apoptosis. ".

Source link: https://europepmc.org/article/MED/35543207


Exosome-transmitted circVMP1 facilitates the progression and cisplatin resistance of non-small cell lung cancer by targeting miR-524-5p-METTL3/SOX2 axis.

"Here, we investigated the role of circRNA vacuole membrane protein 1 in NSCLC progression and cisplatin resistance. " Results CircVmp1 was markedly elevated in DDP-resistant NSCLC cell lines in comparison to their parental cell lines. CircVMP1's silencing restrained A549/DDP and H1299/DDP cells' malignant activity and DDP resistance, which were discouraged by miR-524-5p. In the serum samples of DDP-resistant NSCLC patients with contrast to DDP-sensitive patients, Exosomal circvMP1 was up-regulated. Exosome-mediated transmission of cirVMP1 has been enhanced in DDP-resistant cell lines in A549/DDP and DDP/DDP cells, as well as DDP-resistant cells. For the first time, CircVMP1 affects NSCLC progression and DDP resistance, while DDP-resistant cell lines are included in the CRC's DDP and H1299/DDP cells. CircV1-related cells' DDP resistance to DDP/MircVircvMP1-MiR-MiR-MiR-MiR-MiR-MiR-M1-MiR12 axis.

Source link: https://europepmc.org/article/MED/35467477


Caudatin blocks the proliferation, stemness and glycolysis of non-small cell lung cancer cells through the Raf/MEK/ERK pathway.

"Context" (text) "Context": "Multi cancers have investigated caudatin's antitumor effects, but lung cancer research has not been fully understood. In vitro and in vivo, we investigated the effects of caudatin on non-small cell lung cancer in vitro and in vivo. Subcutaneous tumor xenografts were developed by injecting the nude mice with 5 u00d7 10 6 H1299 cells. All nude mice were divided into the caudatin group and the sham group in the in-vivo experiments. H1299 and H520 cells' IC 50 of caudatin were 44. 68 bcM and 69. 37 u03bcM, respectively, according to IC 50. Cell apoptosis rate was up about 10 times in caudatin 0 u03bcM group, while cell stemness was reduced by 75% in the caudatin 100 bcM group, with cell stemness down by 75%. For the first time, caudatin inhibited stemness and glycolysis in NSCLC. "In vivo, more experiments on the precise dosage of caudatin should be carried out. ".

Source link: https://europepmc.org/article/MED/35387566


Loss of ubiquitin-specific peptidase 18 destabilizes 14-3-3ζ protein and represses lung cancer metastasis.

"Cancer metastasis is a common cause of cancer-related mortality. " This review explores whether USP18 deficiency reduced lung cancer metastasis. Small hairpin RNAs and small interfering RNAs were used to produce an ineffective lung cancer cells that were not independently obtained using small hairpin RNAs and small interfering RNAs. Reduced lung cancer development, wound-healing, migration, and invasion in comparison to controls, as well as reduced murine lung cancer metastases. The absence of USP18 caused the 14-3-3-3/3 protein in shRNA knock-down lung cancer cells to be limited. Human lung cancer arrays and syngeneic murine lung cancer metastasis models were reported and extended using 14-3-3-3 u03b6 immunohistochemical assays. Engineerered 14-3-3-3-3 u03b6 knock-down in lung cancer cell lines and 14-3-3-3-3-3-u03b6 rescue experiments that reversed migration and invasion inhibition developed, leading to a direct 14-3-3-3-336 role in controlling lung cancer metastasis in controlling lung cancer metastasis.

Source link: https://europepmc.org/article/MED/35387560


Nano-liposomal zein hydrolysate for improved apoptotic activity and therapeutic index in lung cancer treatment.

"Lung cancer is one of the most common cancers in the world with a high mortality rate. " Zein is a protein compound whose protein isolate is ineffective, but whose protein hydrolysis produces biological activity. On the human A549 cell line, the effects of zein hydrolysate and nano-liposomal ZH were investigated in this research. These findings showed that N-ZH with good anticancer activity may be used as a therapeutic agent and a lung cancer prevention strategy in future clinical trials. ".

Source link: https://europepmc.org/article/MED/35363101


Targeted delivery of quercetin by biotinylated mixed micelles for non-small cell lung cancer treatment.

"Lung cancer is the leading cause of cancer death around the world, and treatment remains a challenge in clinic, especially for non-small cell lung cancer. " Cellular uptake findings revealed that biotin conjugation markedly raised 1. 2-fold internalization of the carrier relative to that of non-targeted mixed micelles. In vitro findings showed that Que-MMICs had higher cytotoxicity than Que-MICs and free Que to A549 cells, which produced apoptosis and stopped cell cycle in vivo. Que-MMICs collectively contributed to increased tumor accumulation at the tumor site and demonstrated excellent anticancer activity in the NSCLC bearing mice model. ".

Source link: https://europepmc.org/article/MED/35343862


Exhaled metabolic markers and relevant dysregulated pathways of lung cancer: a pilot study.

"Introduction" is the product of a "Introduction" The clinical application of lung cancer detection based on breath test is still difficult due to a lack of specific molecular markers in exhaled breath. Using a common method for metabolomics analysis, this research explored potential lung cancer biomarkers and their related pathways. GC-MS analyzed breath samples from 60 lung cancer patients and 176 healthy people. Original measurements were GC-MS peak intensity removing background noise and removing background noise. Discussion Some of the pathways among them are related to lung cancer risk factors or therapies. In studies based on genome or transcriptome results, however, more of them are dysregulated pathways of lung cancer. Conclusion We believe that it opens the possibility of using metabolomics techniques to analyze data of exhaled breath analysis, as well as the inclusion of knowledge databases to include more volatile metabolites. Imhaled breath Diagnostic significance Although a series of related studies published diagnostic results with high accuracy and specificity, the clinical application of lung cancer detection based on breath test is still difficult due to disease heterogeneity and a lack of predictable molecular markers in exhaled breath. Key findingsIn the present study, 11 pathways involving 8 potential biomarkers were found to be dysregulated pathways of lung cancer, which may lead to reduced mortality in the future. We also found that metabolomics techniques can be used in analysis of breath test results, which is useful to identify consistent volatile markers with definite pathological and histological significance.

Source link: https://europepmc.org/article/MED/35261323


Radiotherapy-induced enrichment of EGF-modified doxorubicin nanoparticles enhances the therapeutic outcome of lung cancer.

"Therefore, it is also important to investigate new ways for enhancing the clinical outcomes while minimizing the side effects of chemotherapy in the treatment of NSCLC. " We engineered and synthesized epidermal growth factor nanoparticles that selectively targets the epidermal growth factor receptor overexpressed in lung tumor cells, which was modulated in epidermal growth factor receptor overexpressed in lung tumor cells. In vitro, EGF@DOX-NPs significantly reduced the viability and migration of tumor cells, as well as elevated tumor cell apoptosis rates. "These findings show that radiotherapy may be used in combination with EGF@DOX-NPs for lung cancer treatment in combination. ".

Source link: https://europepmc.org/article/MED/35156493

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions