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Long COVID - Wiley Online Library

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Last Updated: 07 April 2022

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Histopathology of Persistent Long COVID Toe: A Case Report

With histopathologic capillary thrombosis of toes, a 59-year-old obese man with probable COVID 19 developed painful cyanosis, a painful thrombosis of toes, and the cyanosis remained for nearly 22 months. His anti-SARSCoV2 antibody and nasal swab RT-PCR results were repeatedly negative, shortly after being introduced to family members with documented SARSCoV2 symptoms, onwards. This is the first case of biopsy of "long COVID toe" following suspected SARSCov2 exposure, with signs of thrombotic vasculopathy, toe cyanosis, and perniolike pathology.

Source link: https://onlinelibrary.wiley.com/doi/10.1111/cup.14240


The COVID‐19 pandemic and long‐term incentives for developing vaccines: Patent law under stress

We find that the new international IP law framework and the Trade-Related Aspects of Intellectual Property Rights Agreement are not insurmountable barriers to access to a highly effective COVID-19 vaccine. In addition, the current wave of medical research on COVID1919 indicates that the earlier vaccination R&D ‘failures' were largely triggered by the modest demand for such vaccines and not due to a lack of incentives, according to a deteriorating IP infrastructure. The paper also states that today's EU competition legislation on the horizontal exchange of data could be viewed as an obstacle to innovation and therefore temporarily suspended.

Source link: https://onlinelibrary.wiley.com/doi/10.1111/jwip.12223


Relationship between changes in symptoms and antibody titers after a single vaccination in patients with Long COVID

Coronavirus disease 2019 is spreading globally; Long COVID is a form of Coronavirus disease. This research investigated postvaccination changes in symptoms and antibody titers in patients with Long COVID. Patients attending our hospital's outpatient department specializing in Long COVID were accepted. The higher incidence of the antibody titer in the worsened group than in the nonworsened group demonstrates an increased immune reaction to vaccination that has triggered sequelae. Although patients with Long COVID should be vaccinated, additional questions should be addressed.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/jmv.27689


Chronic cerebral aspects of long COVID, post‐stroke syndromes and similar states share their pathogenesis and perispinal etanercept treatment logic

The persistent physiological features of traumatic brain injury, post-stroke syndromes, long COVID 19, persistent Lyme disease, and influenza encephalopathy are all present in a comprehensive manner, which warrant investigating in a coordinated manner. Although TNF maintains cerebral homeostasis, its excessive production in terms of both pathogen-related molecular structures or damage-associated molecular patterns activity correlates with the persistence of the disease in both infectious and non-infectious conditions. The claim is that this shared continuity arises from a positive feedback loop that results in the persistence of microglia activation by TNF produced by these cells.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/prp2.926


A novel COVID‐19 sentiment analysis in Turkish based on the combination of convolutional neural network and bidirectional long‐short term memory on Twitter

During the pandemic, a new life was started by necessity, where people have often used social media to express their feelings and find information. Although studies in Turkish sentiment analysis are lacking in the academic field, the majority of the related works deal with sentiment analysis in English. To classify a given tweet into three sentiment categories, namely, positive, negative, and neutral, the proposed deep neural network model was developed on the created Twitter database, which contains 15k Turkish tweets about the COVID19 pandemic.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/cpe.6883

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions