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Here the authors chronicle the evolution of post COVID-19 signs in the ComPaRe long COVID prospective e-cohort. About 1% of people with severe acute respiratory syndrome coronavirus 2 infection have symptoms of post COVID-19 disease. We reviewed the data from 968 adult patients with a confirmed disease enrolled in the ComPaRe long COVID cohort, a disease-prone prospective e-cohort of such patients in France. Patients' responses to the Long COVID Symptom Tool, a nationally validated self-reported questionnaire assessing 53 symptoms, was determined by day-by-day prevalence of post COVID-19 symptoms.
Source link: https://doi.org/10.1038/s41467-022-29513-z
Patients after hospital discharge may be affected by Long COVID-19, which may have a long history. Aims This paper seeks to explore the potential consequences of clinical problems in COVID-19 patients for long-term duration. Methods We conducted a systematic review by using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guideline. COVID-19 was found in studies that included information on the prevalence of somatic clinical signs lasting at least 4 weeks after the onset of a PCR- or serology-confirmed diagnosis of COVID-19. The persistence of these conditions was lower in nineteen studies in the majority of out-patients, with 3% to 74% of patients reporting persistent smell and taste disorders. COVID-19 patients should have access to coordinated multidisciplinary healthcare that promotes a holistic approach. Patients with long-COVID-19 require coordination across several sub-specialties, which can be designed in specialized post-COVID units.
Source link: https://doi.org/10.1007/s10096-022-04417-4
CDC-19 is the most common form of acute COVID in children. Children's SARS-CoV-2 disease recovery from SARS-CoV-2 disease has been shown by only few, mostly non-controlled studies with small sample size. A national cohort study of 37,522 children aged 0–17 years with RT-PCR confirmed SARS-CoV-2 infection and a control group of 78,037 children. Both SARS-CoV-2 children and controls had symptoms lasting > 4 weeks. However, SARS-CoV-2 children aged 6–17 years reported illnesses more often than the control group. Not able to see them anymore, impairment of taste RD 0. 01, loss of smell RD 0. 01, and muscle weakness RD 0. 01 are the most common signs among pre-school children. RD 0. 12, loss of smell, RD 0. 10, exhaustion RD 0. 02, muscle weakness RD 0. 02, and chest pain RD 0. 01 were the most common signs among school children. Children in the control group had significantly higher concentration issues, headache, muscle and joint pain, cough, nausea, diarrhea, and fever than those in SARS-CoV-2 infected. Symptoms in most children's "long COVID" symptoms improved within 1 to 5 months. Long COVID in children is extremely rare and mainly of short duration. • Only few studies have evaluated the long-term effects of COVID-19 in children, and the majority of all studies lacks a control group, and few studies lack a control group. What is New: When compared to a control group, 0. 8% of SARS-CoV-2 positive children experienced symptoms lasting longer than 4 weeks.
Source link: https://doi.org/10.1007/s00431-021-04345-z
Purpose Metabolic disorders have been identified as significant risk factors for severe acute courses of COVID-19. With decreasing numbers of infections in several countries, the long COVID syndrome, as well as the precise identification of risk factors for LCS growth, represents the next big challenge in pandemic management. 1,708 people were diagnosed with LCS among the 50,402 COVID-19 patients included in this study, while 1,708 were diagnosed with LCS.
Source link: https://doi.org/10.1007/s15010-022-01784-0
BACKGROUNDING SARS-CoV-2 infection has affected millions of people around the world. A thorough knowledge of this new disease and its associated needs is critical during COVID-19's recovery phase, but rehabilitation services may help individuals during the recovery phase of COVID-19. This qualitative report looked at individuals who had been hospitalized for COVID-19, focusing on those areas and challenges they felt were most critical. Methods This naturalistic qualitative report was part of a single-center mixed-method cross-sectional study published in Italy during the first peak of the SARS-CoV-2 pandemic. "Tell me, how has it been going since you were discharged?" was the primary research question addressed. 784 people with COVID-19 were dismissed from the Hospital of Reggio Emilia's Province of Reggio Emilia's first peak of the COVID-19 pandemic, inability to participate in the study protocols, insufficient medical documentation to allow for testing, discharge to residential facilities, and pregnancy. Overall, 151 people pledged to participate in the REACT study, and 56 people were interviewed in June–July 2020, leading to data saturation. Conclusions The participation of symptoms reported in PASC confirms the persistence of symptoms identified in PASC and emphasizes feelings of loneliness and psychological distress.
Source link: https://doi.org/10.1186/s12889-022-13035-w
Background This multicentre research sought to provide a qualitative and consensual description of brain hypometabolism in patients with alleged neurological long COVID, as well as in the brainstem and cerebellum. Methods Patients referred for alleged neurological long-CoviD with positive reverse transcription polymerase chain reaction (BFP) and/or serology tests for SARS-CoV-2 infection were retrospectively reviewed in three French nuclear medicine departments from the start of August 2021 to the end of October 2021. According to the COVID hypometabolic model, 53% of the scans were interpreted as normal, 21% as moderately to moderately affected, and 26% as severely impaired.
Source link: https://doi.org/10.1007/s00259-022-05753-5
Background Two sequelaes of pediatric COVID-19 have been identified, as well as the multisystem inflammatory syndrome in infants and long COVID. Long COVID is much less specific, and it encompasses all of the persistent or new clinical manifestations reported in SARS-CoV-2-infected patients who have been infected with the acute disease for a long time, which cannot be explained by an alternative diagnosis. The Intersociety Consensus's Pediatric Long COVID, as well as how to identify and treat children with long COVID are discussed. Although the true prevalence of long COVID in pediatrics is not precisely established, it would be useful to investigate signs suggestive of long-coviD near the end of the disease's acute phase, which can range from 4 to 12 weeks from this. To determine the presence of signs of previously unknown disease, it is suggested that the primary care pediatrician visits all patients with a suspected or confirmed diagnosis of SARS-CoV-2 disease after 4 weeks. In any event, a further examination by the primary care pediatrician should be scheduled 3 months after the diagnosis of SARS-CoV-2 disease to confirm stability or identify emerging issues. Children and adolescents with obvious signs of mental distress will need to be followed by existing local services for problems of this sort. Health officials and government must coordinate COVID-19 pandemic treatment for all the children affected by the disease, as well as public health concerns.
Source link: https://doi.org/10.1186/s13052-022-01233-6
SARS-CoV-2 infects cells by its spike protein binds to its surface receptor on target cells, resulting in acute symptoms, particularly the lungs, which are identified as COVID-19. CoVID-19 direct mammalian cells vaccines have been produced so far by either mRNA or an adenovirus vector to produce the spike protein, or by administering recombinant spike protein, which is recognized by the immune system leading to the production of neutralizing antibodies. One paper found perivascular inflammation in brains of deceased patients with COVID-19, but others showed that the spike protein could damage the endothelium in an animal model, undermined an in vitro model of the blood-brain barrier, and caused perivascular inflammation.
Source link: https://doi.org/10.1007/s12035-021-02696-0
In a prospective population in Northwest Spain, the aim of this study is to chronicle persistent symptoms 6 months after COVID-19 diagnosis. Following SARS-CoV-2/COVID-19 diagnosis, this cohort includes patients in a clinical follow-up in a health population of 569,534 people. Long COVID long COVID's multivariate analysis found COPD, women gender, and nicotine intake as risk factors for long COVID. Compared to outpatients, persistent symptoms are common after COVID-19 especially in hospitalized patients. Based on these findings, a special interest and clinical follow-up should be provided to hospitalized patients with previous lung diseases, tobacco use, and women.
Source link: https://doi.org/10.1038/s41598-022-07414-x
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