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As shown by imaging, six-minute walk, and lung function tests, the Lung injury can persist during the recovery period of COVID-19. The aim of this study is to investigate the sources of pulmonary susceptibility during sequelae, as well as the fact that prothrombotic states may have long-term pulmonary signs of COVID-19. We further investigate the possibility that prothrombotic states, such as pulmonary vascular endothelial cell activation and hypercoagulability, may influence long-term pulmonary health in patients with pulmonary functional lesions and organic lesions. Early use of combined anticoagulant and antiplatelet therapy may be a promising way to minimize the incidence of pulmonary sequelae. Since impaired pulmonary circulation leads to significant pressure imbalances over the alveolar membrane leading to plasma infiltration into the alveolar cavity, inhibition of thrombotic activities can reduce pulmonary hypertension, lung hyaline membrane formation, and lung consolidation.
Source link: https://doi.org/10.3389/fimmu.2022.862522
Many discharged COVID-19 patients affected by sequelae experience reduced quality of life, their families, and society as a whole, placing a strain on the healthcare system, family, and society as a whole. Long COVID's possible pathophysiological causes include: persistent viral replication, chronic hypoxia, and inflammation. Long COVID is, in effect, a thrombotic sequela. Long COVID is a chronic illness that has no approved treatment. SARS-CoV-2 can travel through the circulation and attack distant tissues and organs, which can be distributed by many species of cells. The resulting reduced lung function and chronic hypoxia also exacerbates vascular inflammation and coagulation abnormalities. We also summarize new results on antithrombotic therapy in COVID-19, in this series. In fact, persistent systemic inflammation and thrombosis dysfunction are key factors contributing to various conditions of long COVID.
Source link: https://doi.org/10.3389/fcimb.2022.861703
SARS-CoV-2 infection has affected millions of people around the world, according to a paper based on a global basis. A comprehensive knowledge of this emerging disease and its associated needs is crucial. This qualitative report looked at individuals who had been hospitalized for COVID-19, focusing on those areas and challenges they felt were most urgent. Methods This naturalistic qualitative research was part of a single-center mixed-method cross-sectional study carried out in Italy during the first peak of the SARS-CoV-2 pandemic. “Tell me, how has it been going since you were discharged,” was the main research question addressed. 784 people with COVID-19 were discharged from the Hospitals of Reggio Emilia's Province of Reggio Emilia's Local Health Authority, inability to participate in the study procedures, inadequate medical information to enable for screening, discharge to residential facilities, and pregnancy. Overall, 150 people agreed to participate in the REACT research, and 56 people were interviewed in June–July 2020, up to data saturation, which was up to data saturation. Conclusions The participant's report revealed the persistence of symptoms identified in PASC, as well as the sense of loneliness and psychological distress.
Source link: https://doi.org/10.1186/s12889-022-13035-w
In some COVID-19 patients, symptoms persist for several weeks, and occasionally, following the acute disease course, these patients experience new signs, which then leads to a transition to the so-called long COVID.
Source link: https://doi.org/10.1016/j.bbih.2022.100455
Both in the acute care of COVID-19 patients and in the consequences, the SARS-CoV-2 pandemic has caused the global health system to face new challenges. We conducted a preliminary investigation in order to determine the prevalence of long-coviD in a cohort of Italian children with previously reported SARS-CoV-2 infection, and see if breastfeeding might have a role in modulating long COVID incidence.
Source link: https://doi.org/10.3389/fped.2022.884962
Long-COVID is a new emerging disease worldwide that is characterized by the persistence of unsolved signs and symptoms of COviD-19 more than four weeks after the disease and after more than 12 weeks. In a comparison with people who recovered fully in the first 12 weeks after the infection, we investigated the usefulness of several socioeconomic, medical, and immunological measures as diagnostic biomarkers of Long-coviD in one cohort of Spanish people with signs and symptoms of this disease after 48 weeks post-infection. We found that people with Long-COVID had significantly elevated levels of functional memory cells with high antiviral cytotoxic activity, including CD8+ TEMRA cells, CD8+ cells, and NK cells with CD56+CD57+NKG2C+ phenotype. The persistence of these long-lived cytotoxic populations was aided by increased levels of CD4+ Tregs and the expression of the exhaustion marker PD-1 on the surface of CD3+ T lymphocytes.
Source link: https://doi.org/10.3389/fimmu.2022.848886
Objectives: The post-COVID-19 signs experienced by many survivors have a more severe effect. This report sought to investigate the risk factors associated with long COVID-19 in a prospective cohort of hospitalized patients, as well as those who require intensive care unit transfer, taking into account objective measures of COVID-19 severity. Methods: Patients with confirmed COVID-19 were admitted to hospitalized hospitals, with confirmed COVID-19. To determine the relationship between parameters at the acute phase and persistent symptoms, multivariable adjusted regression models were used to compare the relationship between parameters at the acute phase and persistent symptoms.
Source link: https://doi.org/10.1016/j.ijid.2022.03.006
Objectives: This multicenter research examined the recovery curve of the number of post-COVID-19 signs in newly hospitalized patients using an exponential decay model and mosaic plots. Methods: Patients hospitalized in Madrid, Spain, were scheduled for two telephone interviews at two follow-ups with a 5-month absence, with a 5-month period in between and being asked about the presence of post-COVID-19 symptoms. Result: After hospitalization, a total of 1593 patients with COVID-19 were rated 8. 4 and 13. 2 months.
Source link: https://doi.org/10.1016/j.ijid.2022.02.010
On Days 9 and 11, the number of patients with a lack of energy and pain symptoms was significantly less in the Chisan ® treatment group than in the placebo group. Except for marginally lower IL-6 in the Chisan ® treatment group, a scientific review of blood markers of inflammation response and blood coagulation revealed no significant difference over time between treatment groups. In addition, a significant difference between the placebo and Chisan ® therapy was seen for creatinine: Chisan ® significantly decreased blood creatinine compared to the placebo, suggesting prevention of renal failure progression in Long COVID.
Source link: https://doi.org/10.3390/ph15030345
Long COVID is a disease distinguished by long-term sequelae that occur or persist after COVID-19's convalescence period. During the COVID-19 pandemic, more and more people who tested positive for SARS-CoV-2 developed long COVID, which attracted the attention of researchers. This report will investigate the trend of long COVID research papers, analyze the study areas, and give insight into long COVID long term COVID research. In this analysis, we obtained 784 publications from Scopus in the field of long COVID. Nature Medicine had the most citations out of citations, with the International Journal of Environmental Research and Public Health and the Journal of Clinical Medicine as the top journals in the list of publications count, with the International Journal of Environmental Research and Public Health as the leading journals in the field of publications count. The causes of long-covidial fever may be attributed to organ damage, inflammation, misadaptation of the angiotensin-converting enzyme 2 pathway, and mental factors. At least one long-term disease is common in patients.
Source link: https://doi.org/10.3390/ijerph19063742
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