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Long COVID - Crossref

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Last Updated: 07 April 2022

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Abstract EP18: Cardiopulmonary Testing In Long Covid Versus Non-CovidPatients With Undifferentiated Dyspnea On Exertion

Objective: To compare CPET findings of long COVID patients with undifferentiated dyspnea in the Mayo Clinic with undifferentiated dyspnea on exertion. The study included 77 PASC patients who were confirmed by a positive antigen or PCR test with no prior history of heart or lung disease. Patients with unspecified dyspnea with no known diagnosis of cardiac or respiratory disease were compared to 766 non-COVID patients with unspecified dyspnea without a single diagnosis of cardiac or respiratory disease. Results: The post-COVID patients were younger and more likely to be female than those in the control group. Although there were some significant differences in the CPET results, the most notable were a lower FAC and peak VO2 in the study group, with a lower FAC and peak VO2. Also, CNS changes during CPET were reported at higher rates, whereas dyspnea in post-COVID patients was at lower rates. Conclusions: Long COVID patients have a high incidence of severe exercise deficiency.

Source link: https://doi.org/10.1161/circ.145.suppl_1.ep18


The Long-Term Distributional and Welfare Effects of Covid-19 School Closures

Public investment in education is mixed with parental time and resources invested in the creation of child human capital at various stages of the children's growth process, according to the model. Younger children are more affected by school closures than older children due to self-productivity in the human resource production process.

Source link: https://doi.org/10.1093/ej/ueac028


Case Report: Therapeutic and immunomodulatory effects of plasmapheresis in long-haul COVID

Patients with COVID-19 are often debilitating symptoms months after being infected, a condition that is termed long-lived COVID. The patient returned to normal activities and work after two rounds of therapeutic plasma exchanges. In the patient's peripheral blood mononuclear cells, markers of inflammatory macrophages were reduced, and lymphocyte markers, including natural killer cells and cytotoxic CD8 T-cells, increased.

Source link: https://doi.org/10.12688/f1000research.74534.2


Multi-Omics Integration Reveals Only Minor Long-Term Molecular and Functional Sequelae in Immune Cells of Individuals Recovered From COVID-19

The majority of COVID-19 patients experience a mild to moderate disease course and recovery within a few weeks. An increasing number of studies characterized the long-term changes in the specific anti-SARS-CoV-2 immune responses, but how COVID-19 influences the adaptive and heterologous adaptive immune system after recovery is less well understood. After COVID-19, we found that immune responses generally recover without major sequelae. In conclusion, we suggest that the immune system of convalescent COVID-19 patients largely recovers to the homeostatic level of healthy individuals despite small differences in epigenetic and transcriptional services.

Source link: https://doi.org/10.3389/fimmu.2022.838132


Host–pathogen dynamics in longitudinal clinical specimens from patients with COVID-19

Abstract SARS-CoV-2 sequencing data has been rushed to public repositories, allowing widespread study of viral genomes, but studies of longitudinal samples from infected individuals are still limited. Here we sequenced 49 longitudinal SARS-CoV-2-positive samples from 20 patients in Washington State collected between March and September of 2020. Viral counts faded over time, with an average rise in RT-QPCR cycle threshold of 0. 87 per day falling over time. Differential gene expression analysis revealed a downregulation of cytoskeletal genes that was consistent with a lack of ciliated epithelium during infection and recovery in a subset of samples sequenced using metagenomic techniques. We also discovered co-occurrence of bacterial species in samples from multiple hospitalized patients. These results show that SARS-CoV-2's intrahost genetic composition is flexible throughout COVID-19's course, and highlight the importance of ongoing monitoring and deep sequencing of minor variants.

Source link: https://doi.org/10.1038/s41598-022-09752-2

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions