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Liver Disease - Springer Nature

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Last Updated: 20 April 2022

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Attitudes of Chinese Patients with Non-alcoholic Fatty Liver Disease Toward Participation in Clinical Trials from a National Multicenter Survey

Background Annotation of these studies is a growing body of non-alcoholic fatty liver disease drugs being tested in clinical trials, but few of these trials were conducted in China. We investigated the contributing factors that influenced Chinese patients' attitudes in CTs of non-alcoholic fatty liver disease in non-alcoholic fatty liver disease. Methods A questionnaire was designed to be completed by patients with non-alcoholic fatty liver disease at eight affiliated hospitals around China. Improving liver fibrosis or cirrhosis, as well as lowering fat in liver were among the desired safety of new medications. More than a third of Chinese patients with NAFLD in this survey are interested in CTs of NASH. Potential effects of NASH treatment on reversing fibrosis or cirrhosis will positively influence, according to the study's findings, while adverse effects of the latest drug and the requirement of multiple liver biopsies could negatively influence enrollment in the study.

Source link: https://doi.org/10.1007/s43441-022-00380-6


B-cell lymphoma 6 alleviates nonalcoholic fatty liver disease in mice through suppression of fatty acid transporter CD36

Nonalcoholic fatty liver disease is a common disease that occurs in a variety of conditions, including steatohepatitis, advanced fibrosis, and liver cirrhosis. B-cell lymphoma 6 is a transcriptional inhibitor that is essential for germinal center B-cell formation. We induced hepatic BCL6 overexpression in our study, as well as conditional liver-specific BCL6 knockout mice. In mice models maintained on a HFD diet, we discovered that BCL6 overexpression increased insulin resistance and hepatic steatosis. The translocase fatty acid CD36, which was found to be a transcriptional target of BCL6 that plays a role in hepatic steatosis, was determined by Mechanistically. BCL6 is bound specifically to the CD36 promoter region, restraining CD36 transcription under physiological conditions. These results show that BCL6 may possibly be targeted in NAFLD therapy.

Source link: https://doi.org/10.1038/s41419-022-04812-x


Value of the triglyceride glucose index combined with body mass index in identifying non-alcoholic fatty liver disease in patients with type 2 diabetes

Background The triglyceride glucose index along with body mass index is a new measure that measures insulin resistance. We wanted to determine the predictive value of the triglyceride glucose-body mass index in relation to the occurrence of non-alcoholic fatty liver disease in the Chinese population with type 2 diabetes in this cross-sectional study. Methods We selected 826 patients with T2D who were hospitalized at the Department of Endocrinology and Metabolism of Karamay People's Hospital from September 2016 to October 2018 for this study. Any degree of echogenic improvement of liver tissue and the liver seemed brighter than ultrasound retinal cortex, suggesting NAFLD. The odds ratios for the TyG-BMI were between 6. 535 and 4. 868 before and after correction, respectively.

Source link: https://doi.org/10.1186/s12902-022-00993-w


Characterization of microbiome and metabolite analyses in patients with metabolic associated fatty liver disease and type II diabetes mellitus

Methods For the purpose, we retrospectively reviewed the medical records of 20 patients with MAFLD, 20 cases with MAFLD and T2DM, as well as 19 healthy donors. Results compared to those in the Ctr group, patients with M or MD diagnosed multifaceted similarities and differences in liver function diagnostics. We discovered that gut microbiota and lipid metabolism were distinct among the indicated groups with the support of microbial and metabolite testing, as well as bioinformatic evaluations. Conclusions The patients with MD revealed multifaceted similarities and differences in their microbiome and metabolites with those in the M and HD groups, as well as the significantly expressed microbes and lipid metabolites, which may ultimately support the clinical diagnosis of MAFLD and T2DM.

Source link: https://doi.org/10.1186/s12866-022-02526-w


A cross-sectional study of alcohol consumption and alcoholic liver disease in Beijing: based on 74,998 community residents

Background The alcohol intake pattern, alcoholic liver disease prevalence, and other risk factors among drinkers in Beijing haven't been fully explained. Moreover, a ten ml blood sample was collected from each subject to determine liver function, routine blood tests, Hepatitis B Virus, and Hepatitis C Virus. Drinking strong spirits often leads to liver steatosis. In addition, ALD prevalence in participants over 25 years old was at 3. 6 percent. The differences in ALD prevalence between men and women, as well as other age groups, were significant. ALD risk factors in Beijing included gender, age, high waist circumference, elevated blood pressure, elevated blood sugar level, and heavy drinkers, according to our report. The Beijing level of alcohol intake is at upper middle level in comparison to other cities or regions in China. However, the ALD prevalence is likely because ethanol intake is relatively low.

Source link: https://doi.org/10.1186/s12889-022-13175-z


Prevalence and predictors of non-alcoholic liver disease on MRI among patients with Crohn's disease

Background It has been shown that Crohn's disease patients were more likely to suffer non-alcoholic liver fatty liver disease with less metabolic causes. In a cohort of Chinese patients with CD, our aim is to investigate the prevalence, clinical features, and potential signs of NAFLD. Methods Established CD patients who underwent magnetic resonance enterography at our hospital's gastroenterology unit were consecutively enrolled between June 2018 and May 2020, with some surviving CD patients who were not enrolled between June 2018 and May 2020. Patients with NAFLD had longer disease duration, higher body mass index, more frequent use of corticosteroid, and elevated liver function tests, in comparison to those without NAFLD. Conclusions Although chronic CD patients have frequent NAFLD, chronic CD patients have a high incidence of NAFLD in this population, long-term use of anti TNF- does not have no effect on the development of NAFLD.

Source link: https://doi.org/10.1186/s12876-022-02238-5


Implementing the right care in the right place at the right time for non-alcoholic fatty liver disease (NAFLD-RRR study): a study protocol for a community care pathway for people with type 2 diabetes

Background Non-alcoholic fatty liver disease is an emerging disease that affects approximately half of all people with type 2 diabetes. Many with type 2 diabetes have an elevated risk of clinically significant liver-related diseases related to NAFLD, including hepatocellular carcinoma, cirrhosis-related disorders, and liver disease mortality. Methods This is a prospective cohort study aimed at including and assessing a community care pathway for liver fibrosis screening into type 2 diabetes treatment. Our research will reveal vital information about the possibility of establishing a NAFLD pathway for people with type 2 diabetes in primary care. Regular evaluation during implementation will help to ensure a safe and sustainable community health pathway and establish a continuous cycle of primary care education.

Source link: https://doi.org/10.1186/s12913-022-07808-7


Positive association of nap duration with risk of non-alcoholic fatty liver disease in an occupational population in Guangdong Province, China: a cross-sectional study

Historical information A lack of sleep or imbalance in sleep-wake cycles has been connected to metabolic disorders. However, no studies have looked at the connection between daytime napping duration and the risk of non-alcoholic fatty liver disease. In a Chinese population, this research sought to determine the connection between daytime napping duration and the risk of non-alcoholic fatty liver disease. The results revealed a correlation between daytime sleep duration and the risk of non-alcoholic fatty liver disease. In the crude model and the multivariable adjustment model, adjustment for demographic, educational, and metabolic risk factors was shown to be a greater risk of non-alcoholic fatty liver disease in the crude model and the multivariable adjustment model. After multivariable change, this cross-sectional report found that daytime napping duration of 60 min was positively connected to the risk of non-alcoholic fatty liver disease in an occupational population of Guangdong Province.

Source link: https://doi.org/10.1186/s12876-022-02246-5


Association between hypertension and nonalcoholic fatty liver disease: a cross-sectional and meta-analysis study

Hypertension and nonalcoholic fatty liver disease are two symptoms that are not fully understood. This research sought to investigate the connection between hypertension and hepatic ultrasound-diagnosed positive NAFLD in healthy people; to perform a comprehensive meta-analysis combining the results of previous studies; to determine whether hypertension was a risk factor for NAFLD. Hypertension was a risk factor for NAFLD, according to the odds of NAFLD in hypertensive subjects, the odds of NAFLD were 1. 43.

Source link: https://doi.org/10.1038/s41371-022-00686-w


Lifestyle as well as metabolic syndrome and non-alcoholic fatty liver disease: an umbrella review of evidence from observational studies and randomized controlled trials

NAFLD risk or treatment was determined by meta-analysis of observational studies and random controlled trials looking at the relationship of lifestyle and metabolic syndrome with NAFLD risk or treatment. Results In this analysis, a total of 37 papers were included in this review: 31 meta-analyses of observational studies were included in this review, and 15 journals reporting 81 meta-analyses of RCTs met the inclusion criteria. In meta-analyses of observational studies, the quality of evidence was rated high only for the association of sugar-sweetened soda intake with increased NAFLD risk. Only three therapeutic interventions from meta-analyses of RCTs with suggestive amounts of evidence were found. Conclusion Despite numerous meta-analyses examining the relationship between lifestyle habits and disease risk and prevention of NAFLD or chronic disease progression, more clinical RCTs are required to investigate the correlations between lifestyle changes and disease progression.

Source link: https://doi.org/10.1186/s12902-022-01015-5

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions