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With T2DM living in Greenland, we wanted to determine the prevalence of liver steatosis and fibrosis among Greenlanders and Danes with T2DM living in Greenland using biochemical surrogate markers. Compared to Danes, Greenlanders had elevated BMI and plasma lipid levels as well as lower HbA1c values. Greenlanders had lower FIB-4 ratings than Danes, 0. 91 vs. 0. 97, without distinction in FIB-4 score categories, with lower FIB-4 scores between them. Despite elevated BMI and plasma lipids, Greenlanders with T2DM had better glycaemic control in conclusion. Greenlanders with T2DM may be less likely to experience liver disease than Danes with T2DM in Greenland, according to these findings.
Source link: https://doi.org/10.1080/22423982.2022.2065755
Introduction: Alcoholic liver disease disorders, alcoholic liver disease, and cirrhosis are all typical liver diseases. The aim of this research was to determine the incidence of alcoholic liver disease among patients admitted to the Department of Internal Medicine of a tertiary care center. Methods: A descriptive cross-sectional research was conducted among 538 patients admitted to the Department of Internal Medicine of a tertiary care center in Nepal between 3rd November, 2021 and 2022, after receiving ethical clearance from the hospital's Institutional Review Committee. Along with frequency and percentage for binary results, as well as mean and standard deviation for continuous measurements, a 95% Confidence Interval was estimated at 95%. In 42 patients, alcoholic liver disease was seen in 538 patients, according to the authors. Conclusions: Our findings showed that the incidence of alcoholic liver disease was lower than that of similarly reported studies.
Source link: https://doi.org/10.31729/jnma.7434
Chronic liver disease is characterized as a non-alcoholic fatty liver disease. Serum uric acid has emerged as a potential predictor of liver damage among the various serum markers in NAFLD. This observational cross sectional research was conducted in Dhaka, Bangladesh, involving 100 patients from BSMMU's department of gastroenterology, with the intention of determining the relationship of serum uric acid level and non-alcoholic fatty liver disease. Comparing the NAFLD group & control revealed differences in serum uric acid, liver enzymes, glycaemic status, serum lipid profile, and anthropometric measurements. Patients with NAFLD had significantly elevated serum uric level in comparison to the non-NAFLD group. The study showed that serum uric acid levels was positively correlated with NAFLD. Serum uric acid may be used as a useful additional marker to determine the likelihood of NAFLD in the clinical setting of metabolic syndrome.
Source link: https://doi.org/10.3329/bsmmuj.v14i4.56611
ABSTRACT Background Supplementation with probiotics, prebiotics, and symbiotics has shown promising results on clinical markers and risk factors for non-alcoholic fatty liver disease in non-alcoholic fatty liver disease. In NAFLD patients, the aim is to determine the effects of supplementation with probiotic, prebiotic, or symbiotic on intestinal microbiota. Methods Two investigators independently searched for articles in Medline databases using PubMed, Web of Science, Embase, Scopus, Lilacs, Central Cochrane Library, Clinical Trials. gov, and the Ovid platform for the gray literature search. After the intervention, three of the three included studies that used prebiotic or symbiotic supplements showed that there were changes in the intestinal microbiota pattern after the treatment. Conclusion Although there is a risk increase in the gut microbiota of people with NAFLD following supplementation with symbiotics or prebiotics, a clinical indication as part of NAFLD therapy is not yet available.
Source link: https://doi.org/10.1590/s0004-2803.202200001-21
Background: Non-alcoholic fatty liver disease is a common cause of hepatic morbidity around the world. NAFLD and Cognitive dysfunction have been reported in a recent study. Objectives: To determine the correlation between NAFLD in patients with or without persistent hepatitis C virus infection and cognitive impairment, as well as cognitive decline. Patients and methods: The study included 100 NAFLD patients diagnosed by abdominal ultrasound according to guidelines for the diagnosis and treatment of non-alcoholic fatty liver disease; 50 percent of them were chronically infected with HCV, and another 50 patients with chronic HCV infection were found without persistent HCV infections. Socioeconomic status of individuals assessed by a socioeconomic status scale. 16% of Group I patients were deficient in Trail-A, Trail-B, and MoCA, while 18% of group II patients were missing in Trail-A, Trail-B, and MoCA. Body mass index and MoCA have a statistically significant negative correlation, with no positive correlation between BMI and Trail A.
Epithelial-mesenchymal transformation is a biological process in which differentiated epithelial cells lose their epithelial characteristics and gain mesenchymal cell migration capacity. Numero studies have shown that ncRNA control of EMT plays a key role in liver disease formation, and several popular ncRNAs have been identified as promising biomarkers for diagnosis and treatment of liver disease. In this article, we explore the connection between different ncRNAs and EMT, as well as the specific molecular mechanism in liver diseases, which may lead to liver disease pathological progression and provide guidelines for liver disease treatment.
Source link: https://doi.org/10.1016/j.biopha.2022.112972
Astragalus mongholicus Bunge [Fabaceae], a traditional Chinese medicine, is commonly used in clinics to treat liver diseases. However, the effectiveness and mechanism of AMB in the treatment of nonalcoholic fatty liver disease remain unclear. The Bioactive components and relevant targets of AMB were tested from the Traditional Chinese Medicine Systematic Pharmacology database, and NAFLD-related targets were found from the GeneCards database, and NAFLD-related targets were selected from the GeneCards database. The STRING database in Then, the AMB-NAFLD protein target interaction network was developed by the AMB-NAFLD protein target interaction network. Quercetin was the most active component of AMB, according to Network pharmacology, and the TNF and MAPK signaling pathways may be the main targets of AMB against NAFLD. Quercetin upregulated the phosphorylation levels of AMPK and reduced the expression of p-MAPK and TNF-. In addition, we found that quercetin may elevate ACC phosphorylation and CPT1 expression in PA-induced HepG2 cells.
Source link: https://doi.org/10.1155/2022/4745042
Background Information It has been shown that Crohn's disease patients were more likely to experience non-alcoholic liver fatty liver disease with less metabolic causes. Methods Established CD patients who underwent magnetic resonance enterography at our hospital's gastroenterology unit were consecutively enrolling between June 2018 and May 2020. Patients with NAFLD had longer disease course, elevated body mass index, more frequent use of corticosteroid, and elevated liver function tests, which was not present in those without NAFLD. Conclusions NAFLD is common in chronic CD patients, but long-term use of anti TNF- appears to have no effect on the development of NAFLD in this population. The clinical nomogram model that incorporates time, serum transaminase, and body mass index may help reduce the risk of NAFLD in patients with CD.
Source link: https://doi.org/10.1186/s12876-022-02238-5
Abstract Background A lack of sleep or sleep pattern in sleep-wake cycles has been attributed to metabolic impairments in children and adolescents. However, no studies have looked into the correlation between daytime napping duration and the risk of non-alcoholic fatty liver disease. In a Chinese population, this research sought to determine the correlation between daytime napping duration and the risk of non-alcoholic fatty liver disease. The results showed a correlation between daytime sleep duration and the risk of non-alcoholic fatty liver disease. In the crude model and the multivariable adjustment model, accounting for demographic, educational, and metabolic risk factors, researchers found a greater risk of non-alcoholic fatty liver disease in the crude model and in the multivariable adjustment model. After multivariable change, an occupational population of Guangdong Province was positively correlated with the risk of non-alcoholic fatty liver disease in a daytime napping duration of 60 min in this cross-sectional review.
Source link: https://doi.org/10.1186/s12876-022-02246-5
Abstract Background The alcohol intake pattern, alcoholic liver disease prevalence, and other risk factors among Beijing alcohol drinkers haven't been fully understood. In addition, a ten-ml blood sample was obtained from each subject to look at liver functions, perform routine blood tests, and Hepatitis B Virus and Hepatitis C Virus. The ethanol intake between men and women, people living in urban and rural areas, was considerably different. Drinking strong spirits leads to liver steatosis, according to experts. In addition, ALD prevalence among participants over 25 years old was 1. 30 percent. The differences in ALD prevalence among men and women, as well as other age groups, were significant. Conclusion The drink consumption in Beijing is at an all-time high in comparison to other cities or regions in China. However, the ALD prevalence is likely because ethanol intake is relatively low.
Source link: https://doi.org/10.1186/s12889-022-13175-z
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