Liver Cancer - Wiley Online Library

A prospective investigation of serum bile acids with risk of liver cancer, fatal liver disease, and biliary tract cancer

"We designed 1:1 matched, nested, case-u2013control studies of primary liver cancer, fatal liver disease, and primary biliary tract cancer in the Alphabet Tocopherol, Beta 2011Carotene Cancer Prevention study. " Seven BAs were positively linked to liver cancer risk, from the highest to the lowest quartile, with taurocholic acid OR, 5. 62; 95% CI, 2. 74; u201311. 52; Q trend 1 is not significant after FDR adjustment; 61; 58; 4. 72; u201311. 52; Q trend 1 is not significant after FDR correction. BAs that were firmly linked to liver cancer and fatal liver disease were largely responsible for liver cancer risk and fatal liver disease, according to investigators who have established mechanistic links between BA metabolism and liver cancer or liver disease. ".

Source link: https://onlinelibrary.wiley.com/doi/10.1002/hep4.2003

Cross‐sectional clinical cancer genomics community of practice survey analysis of provider attitudes and beliefs regarding the use of deceased family member tissue to guide living family member genetic cancer risk assessment

"Next-generation tumor tissue sequencing techniques may aid in the detection of putative germline pathogenic variants, increasing the likelihood that germline cancer predisposition could be identified from archival medical tissue samples of deceased relatives. Provider perspectives on traceback testing have yet to be investigated, so we conducted a cross-u2010 investigation of Clinical Cancer Genomics Community of Practice providers to learn about their attitudes and attitudes toward traceback testing. We investigated responses in the context of whether providers had prior involvement with traceback testing. 84. 0% predicted there would be barriers to implementation, but only 68. 8% of people with prior traceback experience agreed. Both groups thought traceback would be valuable in their practice and that they would be able to discuss the findings with their patients. ".

Source link: https://onlinelibrary.wiley.com/doi/10.1002/jgc4.1587

Numerical analogy of bioheat transfer and microwave cancer therapy for liver tissue

"This study published a numerical analysis of microwave cancer therapy for cylindricalu2010-shaped liver tissue with an ellipticalu2010-shaped liver tumor. " This simulation has investigated the effects of various microwave input power specifications, frequencies, and treatment time on hepatocellular carcinoma, as well as the effects of different microwave input power levels, frequencies, and treatment time on hepatocellular carcinoma, as well as lung tissue texture, time-dependent measurements of temperature, specific absorption rate, and tumor tissue distribution in terms of surface-average transient temperature distribution of tumor tissue. The results show that microwave input antenna strength and frequency have significant effects on liver tissue temperature distribution and SAR values. When the microwave input power is increased along with frequency, the microwave input power and frequency is also increased, SAR and tissue temperature values also rise, but the high temperature is damaging to healthy tissue. ".

Source link: https://onlinelibrary.wiley.com/doi/10.1002/htj.22597

Pain science education for children living with and beyond cancer: Challenges and research agenda

"The understudied and undertreated infant suffering from and beyond cancer is understudied and undertreated. " Pain science education is a fundamental shift in medicine, aiding patients in learning about the biopsychosocial aspects of pain. After ongoing therapy, PSE might be able to benefit childhood cancer survivors who are experiencing persistent pain and pain after active therapy. We want to find difficulties with adapting PSE for children living with and beyond cancer, provide potential solutions, and suggest research findings to guide the introduction of PSE for children living with and beyond cancer.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/pbc.29783

Responsive Hydrogel Based on Triggered Click Reaction for Liver Cancer

"Hydrogel is a soft three-dimensional network material containing a substantial number of hydrophilic monomers" says the author. The click reaction by adding moieties such as nitrobenzyl groups to the network of the cross-u2010 linked nanocomposite hydrogel's network structure in vivo can raise the survival rate and prolong the liver cancer patients' survival time. The use of a nanocomposite hydrogel drug delivery system at the tumor site for a long time will not only raise the drug concentration at the tumor site for a long time, but it will also prevent distant metastasis of residual tumor cells. This systematic review concludes the synthesis methods and related applications of nanocomposite responsive hydrogels with reactions to external or internal physiological stimuli. The physical or chemical stimulations, unit reorganisation, and controlled drug supply can be used for deterministic drug delivery in several states. ".

Source link: https://onlinelibrary.wiley.com/doi/10.1002/adma.202201651

Liver cancer cells with nuclear MET overexpression release translation regulatory protein‐enriched extracellular vesicles exhibit metastasis promoting activity

"MET receptor tyrosine kinase is a cell surface receptor that plays a significant role in embryonic development and tissue regeneration. " Aberrant MET activation has been widely distributed in various human cancers, making it an attractive therapeutic goal. The discovery of truncated MET within the nucleus for potential novel purposes puts a major obstacle to the existing therapeutic approaches against the MET surface receptor. By stimulating the TAK1/NF/NF signal signalling pathway, a previous study has shown the promoting role of nMET in aggressive characteristics of hepatocellular carcinoma cells. Extracellular vesicles mediate tumor microenvironment and tumor metastasis mediated by extracellular vesicles. EVs produced by nMET overexpressing cells increased cell motility and triggered metastasis, triggering metastasis. The promoter of EVs in cell migration invasiveness and metastasis, according to EIF3I, RPS3A, and RPL10's downswing, decreased the promoting role of EVs in cell migration proliferation and metastasis. These translation-u2010related proteins may act as an alternative therapy for patients with nMET overexpression. ".

Source link: https://onlinelibrary.wiley.com/doi/10.1002/jex2.39

Cancer risk in living kidney donors

"We used linked transplant and cancer registry results to find incident cancers among 84,357 kidney donors in the United States. " Using standard incidence ratios, we compared risk with the general population. We used Poisson regression to compare donors with 47,451 Adventist Health Study 2 participants, who usually have healthy lifestyles, for selected cancers. Contributors had similar risks of liver cancer, melanoma, breast cancer, and non-U2010Hodgkin lymphoma as compared to AHS&u20102 donors, but after 7 years of donation, the incidence of colorectal cancer and kidney cancer increased relative to kidney cancer and kidney cancer increased. The increased incidence of kidney cancer in donors' hearts may have contributed to adverse conditions in the donor's "last kidney" in 2019.

Source link: https://onlinelibrary.wiley.com/doi/10.1111/ajt.17082

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