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Liver Cancer - Springer Nature

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Last Updated: 20 June 2022

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A pure nanoICG-based homogeneous lipiodol formulation: toward precise surgical navigation of primary liver cancer after long-term transcatheter arterial embolization

"Purpose Goals To conquer the pivotal challenges of indocyanine green, and thus obtaining a precise surgical navigation of primary liver cancer after long-term transcatheter arterial embolization. " Methods In this research, a simple and green pure-nanomedicine formulation system is introduced to produce carrier-free indocyanine green nanoparticles that are later dispersed into lipiodol via a highly stable homogeneous lipodol formulation method for transcatheter arterial embolization with near-infrared fluorescence-guided precise hepatectomy.

Source link: https://doi.org/10.1007/s00259-021-05654-z


Spatiotemporal modulation of SMAD4 by HBx is required for cellular proliferation in hepatitis B-related liver cancer

"Purpose Hepatitis B virus infection plays a vital role in the development of hepatocellular carcinoma. " Previously, it has been reported that HBx can promote SMAD4 protein expression in liver fibrosis and HCC, but that the drug's regulatory mechanism has yet to be fully understood. Methods qRT-PCR, Western blotting, and IHC revealed SMAD4 protein and protein expression in HCC tissues. Result 1 (1996) We found that SMAD4 was highly expressed in HBV-positive HCC patient samples and was therefore associated with poor prognosis. In vitro and in vivo, the proliferation of HCC cells with a high SMAD4 gene was found to be enhanced, as well as knocking down HBx while replenishing SMAD4 helped stop HCC cell proliferation. We discovered that HBx controls SMAD4 expression at the transcriptional level via TFII-II-II-II-II and can bind to SMAD4 to repress its ubiquitination, which we discovered mechanically. In addition, we found that SMAD4 can advertise HBx expression by providing a positive feedback system. ".

Source link: https://doi.org/10.1007/s13402-022-00683-8


Association of the presence of allergic disease with subsequent risk of liver cancer in a nationwide retrospective cohort among Koreans

A number of studies have suggested an inverse association between allergic diseases and risk of cancer, but only a few studies have specifically investigated the risk of primary liver cancer, including hepatocellular carcinoma and intrahepatic cholangiocarcinoma. " Compared to those without allergic disease, the aHR for overall liver cancer among allergic patients was 0. 77 percent lower than those without allergic disease. The aHR for overall liver cancer in allergic patients with elevated blood pressure is 0. 60 and 0. 77 respectively, but this association was not present in patients with elevated systolic blood pressure is lower than 140 mmHg. Patients with allergic disorders have a significant risk of primary liver cancer in comparison to those without allergic disorders, which supports the rationale for immunotherapy as an effective therapy for liver cancer. ".

Source link: https://doi.org/10.1038/s41598-022-14147-4


The role of YAP1 in liver cancer stem cells: proven and potential mechanisms

"Recent research results show that YAP1 is correlated with the stemness of liver cancer stem cells, and liver cancer stem cells are closely related to YAP1-induced tumor formation and progression. " This essay reviews the latest findings in research into the ways YAP1 promotes liver cancer stem cells and discusses some potential mechanisms that need further investigation.

Source link: https://doi.org/10.1186/s40364-022-00387-z


Comparison of the efficacy and safety of repeated hepatectomy and radiofrequency ablation in the treatment of primary recurrent liver cancer: a meta-analysis

"Background Analysis In order to have evidence-based evidence for future research and clinical use, RH and RFA's treatment of recurrent liver cancer treated in the treatment of recurrent liver cancer treated by RH and RFA. " However, there is no significant difference between repeated hepatectomy group and radiofrequency ablation group in terms of 1-year OS and DFS. In addition, the pooled findings reveal that the postoperative Clavien-Dindo grade II or higher complication rate of the repeated hepatectomy group was significantly higher than the radiofrequency ablation group. RH has a higher OS rate and DFS rate in the treatment of recurrent liver cancer in the treatment of recurrent liver cancer, according to the pooled findings, while the RFA's postoperative complication rate is lower. RH should be the first choice for recurrent liver cancer when survival is the highest priority, according to RH.

Source link: https://doi.org/10.1186/s12957-022-02649-4


Liver cancer and hepatic decompensation events in patients hospitalized with viral hepatitis in Spain

"Background" (Background) "The key causes of decompensated cirrhosis and liver cancer in the United States are chronic viral hepatitis B, C, and D. " In addition, potent oral antivirals have been used to treat HBV for 15 years and HCV since 2014. Methods Using the Spanish National Registry of Hospital Discharges, a retrospective review of all hospitalizations in Spain with HBV, HCV, and HDV as diagnosis was done. In the same way, liver cancer rates for HBV and HCV have recently stalled, but HDV's is still rising. In recent years, the prevalence of hepatic decompensation events and liver cancer in patients hospitalized with HBV and HCV infections has decreased or/or plateaued, according to the widespread use of oral antiviral drugs for these viruses. Patients with hepatitis delta, for whom an affordable antiviral therapy does not exist, continue to rise for patients with decompensated cirrhotic events and HCC.

Source link: https://doi.org/10.1007/s12072-022-10365-0


Liver cancer treatment with integration of laser emission and microwave irradiation with the aid of gold nanoparticles

"Hepatocellular carcinoma is a form of liver cancer with a complicated organ system that usually has a complex appearance, with both superficial and deep sections included. " Simulation results revealed that at the first step, without any injection of gold nanoparticles, 0. 17 percent of the tumor's volume experienced necrosis, while at the next stage, after injection of gold nanorods, the tumor treatment's efficacy was shown.

Source link: https://doi.org/10.1038/s41598-022-13420-w


Protective effects of Persea americana fruit and seed extracts against chemically induced liver cancer in rats by enhancing their antioxidant, anti-inflammatory, and apoptotic activities

"Rats administered DEN/2AAF were orally treated with hydroethanolic extracts of avocado fruits and seeds at a rate of 50 mg/kg b. w. " Moreover, rats treated with avocado extracts showed a marked decrease in liver enzyme activity, total bilirubin levels, and elevated liver tumor markers, but not showed an increase in total protein and albumin levels. Hepatocytes with hyperchromatic and bile duct cystadenoma in rats treated DEN/2AAF were reduced thanks to avocado extract therapy. Moreover, the therapies reduced the lipid peroxidation levels and boosted glutathione peroxidation levels, glutathione-S-transferase, superoxide dismutase enzyme production, glutathione-S-transferase, superoxide dismutase, and glutathione content in liver tissue tissues, which improved the lipid peroxidation levels. In conclusion, the new findings showed that avocado extracts could inhibit hepatocarcinogenesis in rats treated DEN2AAF by inciting antioxidant, anti-inflammatory, and apoptotic properties.

Source link: https://doi.org/10.1007/s11356-022-18902-y


Actin-related protein 2/3 complex subunit 2-enriched extracellular vesicles drive liver cancer metastasis

"We set out to find proteins that contribute to the cellular integrity of EVs derived from metastatic hepatocellular carcinoma cells. " Methods Proteins of EVs obtained from metastatic HCC cells and normal liver cells were tested by mass spectrometry. ARPC2 was highly expressed in EVs of metastatic cells, but it was barely present in non-metastatic HCC cells and normal liver cells. ARPC2 overexpression was linked to poor patient prognosis, according to the TCGA's liver cancer database. Compared to control cells' EVs, cell EVs derived from knockout cells had decreased success in cell growth, motility, and metastasis. Pimozide, a APRC2 inhibitor, also inhibited the promotion of EVs of metastatic cells in mice's lung colonization. Cancer cell proliferation and metastasis are enhanced by EVs with high expression of ARPC2. ARPC2 may be a prospective target for HCC patients''s novel therapy.

Source link: https://doi.org/10.1007/s12072-022-10338-3


In Vitro Cytotoxicity and Apoptotic Assay of Eucalyptus globulus Essential Oil in Colon and Liver Cancer Cell Lines

"Methods" was evaluated in colon cancer cell line SW48, liver cancer cell line HepG2, HEK293t, and skin fibroblast using the MTT assay. After a 48-hour treatment period, Eucalyptus globulus essential oil with a concentration of 0. 01 did not reduce cell viability of SW48 and fibroblast cells. Except in high doses with IC50 = 0. 2 for both cell lines, Eucalyptus globulus essential oil showed no toxic effects on HEK293t and HEPG2 cell lines, except in high dose with IC50 = 0. 2% for both of the cell lines. Conclusion Eucalyptus essential oil had some side effects and was not recommended for use in high doses. In addition, the present research shows that eucalyptus essential oil decreased human colon cancer cell proliferation by inducing apoptosis. Essential oil from Eucalyptus may be a good candidate for colon cancer treatment. ".

Source link: https://doi.org/10.1007/s12029-021-00601-5

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions