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Prohaptoglobin promotes Smad1/5 proliferation in endothelial cells by ALK1, a TGF-type I receptor, suggesting that proHp plays a role in TGF- signaling. However, the role of proHp in cell events downstream of Smads remains unclear. In vitro, the current study investigated the effects of proHp-mediated TGF-Induction and cell proliferation using proHp-overexpressing SK-Hep1 liver cancer cells. Smad1/5's Knockdown of Smad1/5 inhibited proHp's inhibitory effects on TGF-stimulated Smad2/3 phosphorylation and mesenchymal marker expression, according to Knockdown. In vitro, these findings show that proHp suppresses TGF-induced EMT and cell migration by increasing Smad1/5 signaling pathway in SK-Hep1 cells, which also blocks the Smad2/3 signaling pathway. ProHp may prevent a de-differentiation of hepatic cells and cell differentiation by regulating the Smad signaling pathway, according to this review.
Source link: https://doi.org/10.1371/journal.pone.0266409
Background: Liver metastases from breast cancer are often associated with poor prognosis, and treatment options are usually limited to palliative systemic therapy. The impact of liver transplantation on metastasis remains uncertain. The aim of this research is to determine whether liver resection can result in improved survival rates in patients of isolated liver metastases from breast cancer. Methods: We conducted a national cohort study using a claims database from Taiwan's National Health Insurance Research Database. Patients with other metastases between mastectomy and liver metastasis, and those who died after first admission for liver transplantation were also excluded. According to the Kaplan-Meier review, the liver resection group had much greater overall survival than the non-resection group. Conclusion: These results show that liver transplantation may have a greater chance of surviving patients with breast cancer who have new liver metastases post mastectomy.
Source link: https://doi.org/10.1371/journal.pone.0266960
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