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"The systemic drug has traditionally been used for the treatment of the majority of pathological disorders, particularly liver cancer. " Hydrogel-based drug delivery method has less side effects than traditional chemotherapy and can provide tumor-fighting medications for a longer period. Both disease-induced in situ accumulation, as well as subsequent drug release and hydrogel-programmed degradation can be achieved by the chemical and physical flexibility of hydrogels. We review the development strategies of several hydrogels used for localized chemotherapy of liver cancer and their delivery routes, as well as new findings on smart hydrogels herein.
Source link: https://europepmc.org/article/MED/35532174
"Nanomedicine delivery systems can produce precise drug delivery and minimize adverse side effects compared to traditional drug manufacturing methods, but further research is still needed to eliminate obstacles such as multiple drug co-delivery, uncontrolled drug manufacturing, and drug resistance. For the treatment of liver cancer, we created a dual drug-loaded nanosystem that selectively transports and targets tumor cells. The demyaluronic acid-conjugated curcumin and d-u03b1-tocopherol acid polyethylene glycolsuccinate were used as selective drug-carrying devices in this drug delivery system to deliver dasatinib to cancer cells for combined administration. THCD-NPs were clearly cytotoxic to HepG2 cells and could therefore be efficiently taken up by these cells in vitro experiments. In contrast, in vivo experiments, THCD-NPs significantly reduced tumor formation and reduced the adverse side effects of free drugs in a mouse solid tumor model. The nanoparticles we made, in short, provide a new perspective on liver cancer therapy.
Source link: https://europepmc.org/article/MED/35261298
A dual drug delivery targeted at tumor multi-mechanism therapy was made more efficient by using radiofrequency-induced imaging and drug delivery based on magnetic field influence. " The binary nanosystems and doxorubicin were wrapped with a thermosensitive DPPC liposomes with folate-DSPE-PEG 2000 enveloped the fullerene radiofrequency-triggered drug release. The in vitro cytotoxicity of the nanocomposites was demonstrated by the liver metastasis in HT-29 colon cancer cells using radiofrequency. The apoptosis cell death mechanism was confirmed by flow cytometry results. The MFL could also selectively destroy cancerous liver cells in highly co-localized targets due to their superior active tumor targeting and magnetic targeting capabilities.
Source link: https://europepmc.org/article/MED/35147065
"The polymer contains hydrophilic angelica polysaccharide linked by azobenzene linker with ferrocene," the polymer chain is then covalently modified with arachidonic acid, as shown above. " Due to the occurrence of ASP with liver targeting, it was speculated that the polymer micelles could function as an instinctive liver targeting drug delivery carrier. AAAF@Cur can produce hypoxia reaction to drug delivery, according to a In vitro release study. In addition, a series of cell experiments reported that hypoxia could increase cell uptake and thus increase HepG2 cells' proliferation inhibitory activity. ".
Source link: https://europepmc.org/article/MED/34967268
"We created a folic acid-functionalized SMMC-7721 liver cancer cell membrane encapsulated in a scalable nanocrystals system for hepatoma treatment in this study. " FCPN was taken up by SMMC-721 cells and significantly reduced the proliferation of SMMC-7721 cells, which showed that FCPN had excellent targeting capability compared to PN and CPN. FCPN could accumulate significantly in tumor tissues, which explains why FCPN had excellent targeting skills. These results have shown that folate-functionalized homotypic CM bionic nanosystems could be a very effective treatment for liver cancer treatment in the future," these researchers showed.
Source link: https://europepmc.org/article/MED/34962215
"Radical surgery remains the most effective treatment option for gall bladder cancer. " In primary GBC with liver transplantation and incidental GBC patients with puckering of gall bladder beds, segment IVb and V resection is preferred. Select patients with GBC may be eligible for minimally invasive Segment IVb and V anatomic resection with radical lymphadenectomy in selected patients with GBC," this paper states.
Source link: https://europepmc.org/article/MED/35046184
In preoperative images of patients undergoing pancreaticoduodenectomy, "Introduction Liver steatosis has increasingly been described. " In this particular cohort, the aim of the investigation was to determine potential contributors to LS formation. Methods Pancreatic head adenocarcinoma patients scheduled for PD were included in the study, but preoperative CT-imaging was not available. Patients with preoperative LS were matched for patient age, gender, BMI, ASA score, neoadjuvant care, and vascular and multivisceral resections in a 2:1 ratio to patients with no LS, according to propensity results in a 1:1 ratio to patients with no LS. Compared to non-LS patients, LS patients had a higher mean CCI, 29. 7 versus 19. 5, p = 0. 035, and a longer hospital stay, median [IQR] 12 [8-26] days versus 8 [7-13] days, p = 0. 006 versus 8 [7-13] days. Conclusion Preliminary data shows that preoperative LS measured by CT-scan may have an effect on patient undergoing PDAC PD. ".
Source link: https://europepmc.org/article/MED/35717516
"Purpose Hepatitis B virus plays a vital role in the formation of hepatocellular carcinoma. " Previously, it has been reported that HBx can promote SMAD4 protein expression in liver fibrosis and HCC, but that the drug's regulatory mechanism has not been fully understood. mRNA and protein expression of SMAD4 in HCC tissues was determined by qRT-PCR, Western blotting, and IHC. SMAD4 was highly present in HBV-positive HCC patient samples, and was correlated with a poor prognosis, according to the study. In vitro and in vivo, the proliferation of HCC cells with a high SMAD4 gene was found to be elevated, as well as knocking down HBx when replenishing SMAD4 restored HCC cell proliferation. In addition, we found that SMAD4 can promote HBx expression by providing a positive feedback system. Conclusions From our findings, SMAD4 is modulated spatiotemporally by transcriptional activation and protein stabilization by HBx in HCC cells.
Source link: https://europepmc.org/article/MED/35716259
"Creative evidence supports the superiority of global coagulation analysis compared to traditional coagulation methods for clinical decision making. " An acquired prothrombotic state and liver resection for cancer, however, warrants a more thorough investigation. This prospective observational study was conducted to determine the perioperative coagulation status of patients undergoing major hepatectomies for primary or metastatic hepatic malignancy. Patients were accompanied on the 10th day of operative day by serial measurements of conventional coagulation tests, plasma concentrations of coagulation factors, and thrombin generation assay parameters. The ratio of the anticoagulant protein C to the procoagulant FVIII was poor at baseline and later decreased post-operatively, indicating a prothrombotic state. Though no bleeding disorders were identified, one patient suffered pulmonary embolism while under thromboprophylaxis, according to one patient. Patients with hepatic carcinoma undergoing elective major hepatectomy may have baseline malignancy-related coagulation abnormalities, exacerbating the hypercoagulable state that was present in the early post-operative period.
Source link: https://europepmc.org/article/MED/35483884
"However, the role of serglycin in pan-cancer, particularly liver hepatitocellular cancer, is unclear. " The expression and prognostic value of SRGN in LIHC and other pan-cancers was investigated using the bioinformatics databases PrognoScan, GEPIA, Kaplan-Meier Plotter, and TIMER. The SRGN expression, along with stage, grade, AJCC_T stage, sex, race, alcohol intake, liver cancer, and sorafenib treatment in liver cancer was shown by Kaplan-Meier Plotter. T cells CD8+, macrophage M1, macrophage M2, and endothelial cells were highly correlated with SRGN mRNA expression and had prognostic promise in LIHC in the cohort with low or elevated SRGN mRNA expression, according to TIMER 2. 0. In LIHC, the prognostic value of serglycin is limited. However, the pro-tumorigenic properties of SRGN and its closely associated with tumor microenvironment cells may have aided in the creation of new treatment strategies.
Source link: https://europepmc.org/article/PPR/PPR508027
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