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"Artemisia annua and Sophora flavescens are traditional Chinese medicines," says the writer. By network meta-analysis, we found a traditional Chinese medicine that has a major clinical effect on HCC. The LC-MS method was used to determine the active components of Qinghao-Kushen. In HepG2 and HuH-7 cells, the Qinghao-Kushen combination had a significantly higher success than single Qinghao or single Kushen in HepG2 and HuH-7 cells. In HepG2 and HepG2215 cells, Qinghao-Kushen's increased the expression of activated caspase-3 protein than Qinghao or Kushen alone. We reported that Qinghao-Kushen and matrine-scopoletin reduced the expression of GSK-3B2 in HepG2 cells, but that GSK-3u03b2 was more prominent in HepG2215 cells, while HepG2215 cells' expression increased GSK-3u03b2 in HepG2 cells, but that GSK-3u03b2 was decreased. This paper not only demonstrated that the clinical components of Qinghao-Kushen on HCC were matrine and scopoletin, but it also shed light on the inhibitory of Qinghao-Kushen and matrine-scopoletin on liver cancer cells. GSK-3u03b2 may be a potential target for HCC therapy, while HCC therapy may be a target for HCC therapy. ".
Source link: https://doi.org/10.1155/2022/8763510
All PLC patients admitted to The Second Hospital of Dalian Medical University from January 2019 to January 2020 were accepted in group A, 60 patients with liver cirrhosis were included in group B, and 60 healthy participants were admitted to group B, and 60 healthy subjects were included in group C. The serum AFP, TSGF, and GP73 measurements were determined, and all participants were sent for MSCT testing. According to the publishers, AFP, TSGF, and 90. 2%, respectively, while group B, and then group C had the highest AFP, 82. 9%, and 90. 2%, respectively, while others of combined detection of MSCT plus serum AFP, TSGF, and 90. 2% for PLC were 80. 0%, 93. 2%, 100. 0%, 88. 2%, and 100. 0%, respectively. AFP, TSGF, and GP73 serum AFP, TSGF, and GP73 have a higher detection rate than stand-alone detection, which shows promising promise in the diagnosis of PLC. ".
Source link: https://doi.org/10.1155/2022/6581127
Abstract An inverse correlation of allergic diseases and cancer has been suggested by a number of studies, but only a few studies have specifically investigated the risk of primary liver cancer, including hepatocellular carcinoma and intrahepatic cholangiocarcinoma. " A retrospective cohort analysis of the Korean National Health Insurance Service database, which included 405,512 Korean adults aged 40 and above who underwent health screening before January 1st, 2005. The aHR for overall liver cancer in allergic patients was 0. 77 percent higher than those without allergic disease. Patients with allergic disorders have a significantly reduced risk of primary liver cancer compared to those without allergic disorders, which supports the argument for immunotherapy as an efficient treatment for liver cancer.
Source link: https://doi.org/10.1038/s41598-022-14147-4
"Background: Liver cancer is one of the most common malignancies. " LCa's main treatment scheme is Western medicine, but it has not achieved the desired therapeutic effect. Traditional Chinese Medicines have a variety of health, and various studies show that they can kill tumors by regulating the tumor microenvironment and improving the immune system. Object: The aim of this study is to investigate the medication policies of TCMs in treating LCa and excavate the potential TCMs for LCa. Methods: To identify 12 potential target groups by building a prognostic model, we combined genes associated with the MAPK, PI3K/Akt, and mTOR signaling pathways, as well as differentially expressed genes of LCa from the TCGA database, in order to identify 12 potential target targets. To generate a list of main goals, we added 18 previously announced LCa core objectives. To obtain potential herbs for LCa, the targets-compounds-herbs network was established and topologically investigated. A total of 115 candidate chemicals, including resveratrol, quercetin, epigallocatechin gallate, estradiol, and curcumin, were retrieved, as well as 1182 candidate herbs, including Jinyinhua, Goutong, Jemhua, Wichiteng, Nvzhenzi, Sangbaipi, and Qianhu, were discovered, including resveratrol, Goua Some of the potential herbs we found such as Jinyinhua, Gouye, Tufuling, Huzhang, and Qianhu have been shown to be safe for LCa, although some of them, such as Jishiteng, Nvzhenzi and Sangbaipi, have been shown to have a protective effect on the liver. "Net pharmacology and data mining, as a whole, provide novel approaches to TCM screening and exploitation.
Source link: https://doi.org/10.1016/j.prmcm.2022.100086
"This prospective cohort study aims to compare results of patients who received moderately hypofractionated and hypofractionated radiotherapy for liver tumors. " Patients treated for liver cancer with radiotherapy between 2004 and 2020 were prospectively admitted in this study. The second results were a change in toxicity as determined by the Radiation Therapy Oncology Group, from baseline to 6 months; and the change in Child Pugh's score from baseline to 3 months; and change in Child Pugh's from baseline to 3 months. At the 2-year time point, the greater number of patients on hypofractionated regimens were alive at the 2-year mark than those who were moderately hypofractionated regimens; no change was noted at the 1-year time period. Mean toxicity changes in RTOG baseline, 3 and 6 months, and in Child Pugh scores from baseline to three months were not statistically different between the two groups. ".
Source link: https://doi.org/10.1016/j.ctro.2022.04.002
"Backgrounds" "Functional liver imaging can reveal functional liver function heterogeneity and integrate it into radiotherapy diagnosis and integration. Mean functional liver dose was cut by 1. 0 Gy [95%CI: ], mean difference of functional liver volume in u226520 Gy was reduced by 0. 25 percent [95%CI: ] when planning was restricted to sparing functional liver function. Functional liver-sparing radiotherapy results in a low incidence of RILD in the low incidence of RILD, according to a low incidence of RILD, and the single rate meta-analysis revealed that the RILD incidence was 0. 04 [95%CI: P 0. 05]. Functional liver imaging after radiotherapy is a more accurate predictor of RILT than traditional anatomical CT, according to four studies, but incorporation into radiotherapy procedures for liver cancer patients may lead to clinical benefit. ".
Source link: https://doi.org/10.3389/fonc.2022.898435
"ATX has been consistently found in the culture medium of various cancer cells, tumor tissues, and serum or plasma of cancer patients. " In this report, we have summarized the biological role of ATX and the ATX-LPA axis in liver cancer, investigated the ATX-LPA axis in tumorigenesis and metastasis, established the ATX-LPA axis, and explored therapeutic options targeting the ATX-LPA axis, paving the way for new therapeutic developments. ".
Source link: https://doi.org/10.3389/fonc.2022.922945
The development of vaccine candidates for cytotoxic T lymphocytes, particularly T lymphocytes, which are part of cancer immunology, may be a cost-effective treatment for liver cancer. " In our study, which was based on an immunoinformatics research, we predicted potential T cell epitopes of MHC class I molecules using integrated steps of data extraction, screening of antigenic proteins, functional analysis, peptide synthesis, and experimental in vivo experiments. Granzyme concentration increased to 1050 pg/ml at the second booster dose compared to the control, while IgG concentration increased to 6 g/l compared to the control. "On the basis of meaningful findings of specific and nonspecific assays, we concluded that a potential therapeutic trivalent vaccine would activate and modulate the immune system to cure liver cancer. ".
Source link: https://doi.org/10.1155/2022/4792374
Background Information for Future Research and Clinical Use In order to provide evidence-based evidence for future research and clinical use, we conducted a meta-analysis to determine the effectiveness and safety of RH and RFA in the treatment of recurrent liver cancer in order to create evidence-based evidence for future research and clinical use. Results The three-year and 5-year overall survival rate of the repeated hepatectomy group was much higher than the radiofrequency ablation group, according to the pooled results. However, there is no significant difference between the repeated hepatectomy group and the radiofrequency ablation group in terms of 1-year OS and DFS rate. RH has a higher OS rate and DFS rate in the treatment of recurrent liver cancer, according to the pooled results of 8 recent retrospective studies, although the postoperative complication rate of RFA is lower. RH should be the first choice for recurrent liver cancer when survival is the highest priority, according to RH.
Source link: https://doi.org/10.1186/s12957-022-02649-4
"Recent research results show that YAP1 is closely linked to liver cancer stem cells stemming, and liver cancer stem cells are closely linked to YAP1-induced tumor formation and progression. " This article reviews the breakthroughs in scientific understanding into the mechanisms by which YAP1 promotes liver cancer stem cells and discusses some potential causes that necessitate further investigation. ".
Source link: https://doi.org/10.1186/s40364-022-00387-z
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