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"Purpose: Cryoablation is a minimally invasive treatment for primary and metastatic liver cancer. " The aim of this research was to determine the effectiveness of CrA in patients with hepatocellular carcinoma and liver metastases. Methods: Between 2015 and 2020, we retrospectively reviewed the patients who had CrA for HCC or liver metastases. The median survival was also estimated in patients with HCC. Results: In 49 patients with CrA, sixty-four liver tumors were treated. After one month in 92% of lesions treated with CrA, complete tumor ablation was observed. Ten patients underwent redo CrA for local recurrence or incomplete tumor ablation. Conclusions: CrA can be used effectively for the treatment of HCC and liver metastases that are not amenable to surgical resection. Further studies are also required to better define the role of CrA in the multidisciplinary treatment of liver malignancies. ".
Source link: https://doi.org/10.3390/cancers14123018
"However, the role of serglycin in pan-cancer, especially liver hepatocellular carcinomas, is uncertain. " Using the bioinformatics databases PrognoScan, GEPIA, Kaplan-Meier Plotter, and TIMER, researchers investigated the expression and prognostic value of SRGN in LIHC and other pan-cancer. HepG2 cells were transfected with a SRGN overexpressing vector and were transfected with a SRGN overexpressing vector. T cells, macrophage M1, macrophage M2, and endothelial cells were highly correlated with SRGN mRNA expression, and showed prognostic promise in LIHC in the cohort with low or high SRGN mRNA levels. Conclusions The prognostic value of serglycin in LIHC is limited. However, the pro-tumorigenic characteristics of SRGN and its close collaboration with tumor microenvironment cells may aid in the development of new treatment regimens.
Source link: https://doi.org/10.1101/2022.06.15.495916
"Abstract Background: There is an increasing body of evidence that connects modifiable dietary habits and liver cancer use. Methods: We worked with NCI funded U54 Cancer Partnership Community Outreach Core program, using the CBPR approach, to benefit underserved African, Asian, and Hispanic American populations in the Philadelphia metropolitan area and New York City's underserved African, Asian, and Hispanic American communities serving underserved African, Asian, and Hispanic American communities. Participants had average red meat intake and average intake of vegetables and fruits during a 6-month follow-up study, along with their intake at pre-education assessments. Through CBPR community involvement from the two metropolitan areas, this community-based education had major success in improving healthy eating habits and reducing alcohol intake among community members. In: Proceedings of the AACR Virtual Conference on Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Inserved; 2021, October 6-8. ".
Source link: https://doi.org/10.1158/1538-7755.disp21-po-161
To promote HCC surveillance and prevention, detailed race-ethnicity controls are required. " All HCC patients diagnosed in Florida between 2005 and 2018 were compared to statewide hospital discharge data to determine etiology. HCV was the most common cause of HCC White, Black, and Hispanic men in 2012-2015, followed by NAFLD-related metabolic disorders and ALD. HCC was the leading cause of HCC among White and Black women, as well as HCV among Hispanic women, although NAFLD-HCC was the most common form. Although HCV-related HCC incidences are expected to decrease shortly, HCC will continue to impact Hispanicsdisproportionately, based on higher rates of metabolic-HCC and ALD-HCC. Liver cancer and differences among Hispanic groups: The importance of disaggregation in recognizing cancer differences [abstract] is evident [abstract]. Proceedings of the AACR Virtual Conference on Cancer Disparities in Raethnic Minorities and the Medically Underserved; 2021, October 6-8.
Source link: https://doi.org/10.1158/1538-7755.disp21-ia-09
"The overwhelming racial plurality in the United States allows for the measurement of ethnic gaps in HCC risk and outcomes. " Chronic liver disease prevalence and etiology amongst racial groups is variable; nonalcoholic fatty liver disease is most prevalent in Hispanics, while blacks and Asians are most affected by viral hepatitis. In addition to racial in HCC risk, there are significant racial inequalities in the cancer stage of HCC diagnosis and administration of appropriate cancer therapy in HCC. Any stage along the cancer continuum can be affected by clinicians and researchers who can work to improve how individuals with liver disease are treated, which may reduce the risk of HCC and improve outcomes. The AACR Virtual Conference on the Science of Cancer Disparities in Racial/Ethnic Minorities and the Medically Underserved was held in 2021, October 6-8. a> AACR Virtual Conference on the Science of Cancer Disease Disparities in Racial Minorities and the Medically Underserved: The 14th AACR Conference on the Science of Cancer Disparities in Racial Minorities and the Medically Underserved is the 14th AACR Virtual Conference on the 202121 Oct 6-8.
Source link: https://doi.org/10.1158/1538-7755.disp21-ia-43
"Most HCC infections are related to hepatitis B virus and hepatitis C virus," says the spokesperson. Methods: We collaborated with community-based charities funded by the NCI-funded U54 TUFCCC/HC Cancer Partnership Community Outreach Core in the greater Philadelphia metropolitan and New York City to plan and execute a liver cancer prevention and screening initiative in the greater Philadelphia metropolitan and New York City to increase liver cancer prevention and screening. Conclusions: The findings of our research show that educational interventions have boosted liver cancer prevention skills among the minority groups most affected by liver cancer in the United States. [abstract]: Increasing liver cancer prevention for underserved African, Asian, and Hispanic communities through a community-based education campaign to improve liver cancer screening for underserved African, Asian, and Hispanic populations [abstract]. In:: Proceedings of the AACR Virtual Conference on the Science of Cancer Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021, October 6-8.
Source link: https://doi.org/10.1158/1538-7755.disp21-po-058
"Abstract Texas now has the nation's highest reported age-adjusted incidence rate of hepatocellular carcinoma. " HCC-inducing communities tend to have a higher incidence rate of HCC than non-Hispanic Whites. In addition, improved campaigns are now required to inform minority groups on the danger factors that may lead to HCC formation. The HOPE Clinic, a community-based 501 that strives to provide culturally sound healthcare to all Greater Houston Areas. Using focus group results from HOPE Clinic patient participants, the aim of this report is to determine the characteristics of an innovative and retentive intervention scheme that will be relevant to and serving the Greater Houston Area. A total of five focus group interviews were conducted in English, Vietnamese, and Spanish, as well as translated for research to determine patient's risk factors of liver cancer, obstacles to lifestyle changes, and health promotion efforts. Using qualitative methods of analysis, Focus group data was analyzed. The results of this qualitative review revealed themes of health barriers, motivating factors, willingness to participate in intervention services, curriculum development, and past program participation. Overall, there was a consensus that interventions should promote healthy health habits in both younger and older age groups. [abstract]: Qualitative review of focus group data for liver cancer prevention program planning [abstract]. In: Proceedings of the AACR Virtual Conference on the Science of Cancer Disparities in Racial/Ethnic Minorities and the Medically Poor; 2021, October 6-8. ".
Source link: https://doi.org/10.1158/1538-7755.disp21-po-031
"We discovered that a neutralizing antibody against IL-10 promoted tumor apoptosis in patient-derived CRLM tumor slice cultures. " Here, we investigated the IL-10 blockade's safety and immune-dependent mechanisms in a larger cohort of CRLM patients. As previously described, tumor specimens were obtained from consenting patients at the time of surgery and cut into 250mm-thick tumor slice cultures. Tumor slices were treated with either blocking or neutralizing antibodies against programmed cell death protein 1, IL-10, IL-10 receptor alpha, a key histocompatibility complex class I or class II. Our results: We created tumor slice cultures from 34 unique CRLM patients, 76% of whom underwent chemotherapy, and all of whom had either microsatellite stable tumors or unknown microsatellite status, according to the authors. In the majority of 34 CRLM patients' tumors, however, anti-IL-10 increased tumor apoptosis almost twofold relative to control. Tumors treated with anti-IL-10 demonstrated an elevated frequency of CD8+ T cells and a non-significant rise in activated PD-1+CD3+ T cells in a non-significant rise in activated PD-1+ T cells. Macrophage frequency did not rise, but MHC class II expression nearly doubled. We treated human CRLM slices with anti-IL-10+/-blocking antibodies against MHC class I or II, according to the manufacturer's instructions for anti-IL-10 use. To determine which immune cells were required for anti-IL-10 function, we treated human CRLM slices with anti-IL-10 +/- blocking antibodies against MHC class I or II. Tumor apoptosis in a heterogeneous cohort of CRLM patients' tumors was almost doubled by IL-10 blockade in a heterogeneous group of CRLM patients' tumors by a mechanism that required intact CD8+ T cell and antigen-presenting cell function. Interleukin-10 is a common and reversible mechanism of immune clearance in human colorectal cancer liver metastasis [abstract]. ".
Source link: https://doi.org/10.1158/2326-6074.tumimm21-p037
"Abstract Liver metastasis is a significant cause of death among patients with colorectal cancer. " When grown subcutaneously, mouse models of orthotopic pMMR CRC liver metastasis provide an accurate representation of ICB therapy's efficacy in patients, while mouse models of orthotopic pMMR CRC liver metastasis, according to here. To determine CRC tolerance to treatment, we compared the microenvironments of pMMR CRC cells grown as liver metastases and subcutaneous tumors. In ICB-treated orthotopic liver metastases, we discovered a paucity of both activated T cells and dendritic cells, in comparison to their subcutaneous tumor counterparts. In addition, treatment with FMS-like kinase 3 ligand plus ICB therapy enhanced dendritic cell infiltration into pMMR CRC liver metastases and improved mouse survival. We also show that human CRC liver metastases and microsatellite stable primary CRC have a similar paucity of T cells and dendritic cells.
Source link: https://doi.org/10.1158/2326-6074.tumimm21-p061
"Abstract Liver cancer is characterized by chronic inflammation resulting from underlying liver diseases such as liver steatosis. Steatotic liver injury promotes inflammation and establishes the tumor immune environment that can promote liver cancer formation. Previously, we showed that macrophages produce growth factors that promote liver cancer formation in a genetic model in which steatosis and liver tumors were caused by tumor suppressor Pten deletion. We analyzed the expression profiles of these tumors and liver cancer tumors as well as tumors from other mouse models in conjunction with human liver samples in order to determine the recruitment and functions of immune cells in liver cancer. inflammatory cytokines reviewed in virtually every tumor model but attenuated in non-tumor models, according to our review. We also observed significant upregulation of CXCL5 mRNA expression in Kupffer cells, the liver resident macrophages isolated from Pten removed mice isolated from the Pten deleted mice. Our results showed that CXCL5 treatment increased mouse hepatocytes and human HepG2 cells proliferation, which was consistent with mouse HepG2 cells. In Kupffer cells, we investigated the causes of CXCL5 upregulation in Kupffer cells and discovered that lipopolysaccharide stimulates CXCL5 gene expression by nearly 20%. Kupffer cells are thought to be the source of CXCL5 in the Pten deletion mouse model, based on this unique behavior of Kupffer cells. In summary, our results showed that CXCL5 is a novel chemokine produced by Kupffer cells and plays a key role in liver cancer development by steatosis. Steatosis can promote liver cancer formation by stimulating chemokine production from Kupffer cells [abstract].
Source link: https://doi.org/10.1158/2326-6074.tumimm21-p048
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