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"Through the orthogonal self-assembly scheme, Pt metallacycle-based drug delivery platform for precise and synergistic liver cancer therapy, as well as endogenous redox and nitric oxide stimulation" is designed. According to HepG2 liver cancer cells, this device can supply hydrophobic anticancer drug doxorubicin to HepG2 liver cancer cells," according to in vitro studies.
"Liver cancer is the leading cause of death and a global health problem. " Unfortunately, five small-molecule drugs for hepatocellular carcinoma recently failed phase III clinical trials partially because late-stage liver disease amplifies drug toxicity. We overcame this challenge by delivering dendrimer nanoparticles that mediate miRNA delivery to late-stage liver tumors with low hepatotoxicity.
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