Liver Cancer - Astrophysics Data System

β-Cyclodextrin modified Pt(II) metallacycle-based supramolecular hyperbranched polymer assemblies for DOX delivery to liver cancer cells

"Through the orthogonal self-assembly scheme, Pt metallacycle-based drug delivery platform for precise and synergistic liver cancer therapy, as well as endogenous redox and nitric oxide stimulation" is designed. According to HepG2 liver cancer cells, this device can supply hydrophobic anticancer drug doxorubicin to HepG2 liver cancer cells," according to in vitro studies.

Source link: https://ui.adsabs.harvard.edu/abs/2020PNAS..11730942C/abstract

Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer model

"Liver cancer is the leading cause of death and a global health problem. " Unfortunately, five small-molecule drugs for hepatocellular carcinoma recently failed phase III clinical trials partially because late-stage liver disease amplifies drug toxicity. We overcame this challenge by delivering dendrimer nanoparticles that mediate miRNA delivery to late-stage liver tumors with low hepatotoxicity.

Source link: https://ui.adsabs.harvard.edu/abs/2016PNAS..113..520Z/abstract

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