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The viral 3' Open Reading Frame embeds a hydrophobic protein embeds in the cellular membrane, where it acts as an ion viroporin and is linked to high immune response. Here we present equilibrium and enhanced sampling molecular dynamic simulation of the SARS-CoV-2 ORF3a in a model lipid bilayer, showing how the protein permeabilizes the lipid membrane by the establishment of a water channel, which in turn guarantees ion transport. We have provided the free energy profile for both K + and Cl - the transformation from the cytosol to the extracellular domain.
Source link: https://doi.org/10.1101/2022.04.14.488372
The study looked at the role of Aloe vera supplementation on lipid profiles, oxidative stress, liver, and hearing histology in mice raised on high fat and fructose diets. Compared to HFFD-treated mice, the cholesterol levels of HFFD+AV treated mice were significantly lower than those of HFFD-treated mice. HFFD treated mice's albumin level, as well as Catalase and superoxide dismutase enzymes all increased. According to the report, Aloe vera supplementation may help prevent HFFD-induced oxidative stress and hyperlipidemia.
Source link: https://doi.org/10.1101/2022.04.20.488905
The specifics of seipin dysfunction in TG nucleation and LD budding are not well understood. TG is shown by an all-atom simulation that shows that seipin TM segment residues and hydrophobic helices residues embedded in the bilayer's phospholipid tail region attract TG. The seipin TM segments, which are larger, increasingly popular LDs with coarse-grained designs, are designed as a constricted neck panel to enable the conversion of a flat oil lens to a budding LD. We propose a model in which seipin TM segments play a vital role in TG nucleation and LD expansion.
Source link: https://doi.org/10.7554/elife.75808
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