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BACKGROUND Particulate contamination caused by infusion therapy poses a potential health risk for infants in neonatal intensive care units. PATIENTS: Both infants admitted to the NICUs with either umbilical vein catheters in a central position or a centrally embedded central venous catheter will be accepted. With a 1:1 ratio between the two arms of 1:1, the sample size was determined to reveal a difference of 30% between the two arms. PROTOCOL is a pharmaceutical company that supplies infants with the possibility of randomization, after randomization. The aqueous solutions will be delivered via 0. 2 u03bcm filters, which will be changed every 24 hours, will be replaced with blous modality; the lipid emulsions will be administered closer to the patient without the need for filtration, but the infusion line will be closer to the patient without the need for filtering. MAIN OUTCOME Frequency of patients with at least one inflammatory episode sepsis-like, defined by modification of the biomarkers of inflammation in a negative-culture contest, is the prevalence of patients with at least one inflammatory episode sepsis-like, which was characterized by change of the biomarkers of inflammation. SECONDARY OUTCOMES Frequency of patients with at least one inflammatory episode identified by modification of the biomarkers of inflammation in a positive-culture competition. If the use of in-line filters resulted in a substantial reduction in negative-culture inflammatory episodes and/or other conditions, clinical intervention may have been helpful in NICU.
Source link: https://clinicaltrials.gov/ct2/show/NCT05537389
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