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Object: To investigate the difference between P-glycoprotein expression and the absorption of levofloxacin in rats' small intestines between high altitude and plain areas. Methods: As the hypoxic group, Wistar rats kept in Shanghai were used as the normoxic group, and rats rapidly exposed to high altitude via flights were used as the hypoxic group. P-gp's mRNA and protein expression levels were significantly reduced in the hypoxic group compared to those in the normoxic group. The highest values of levofloxacin absorption in the hypoxic group were 19. 99%, 29. 29%, and 45. 4 percent in the duodenum, jejunum, and ileum segments, respectively, at 75 min. For accurate drug administration at high altitudes, knowing the distinct mechanisms of drug transporters under hypoxia is vital.
Source link: https://zenodo.org/record/5713391
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