Levofloxacin - Springer Nature

Levofloxacin versus clarithromycin for Helicobacter pylori eradication: are 14 day regimens better than 10 day regimens?

Patients with H. pylori infection and treated with levofloxacin triple therapy or clarithromycin-based regimen for ten or 14 days were included. Patients were refused if antibiotics or proton pump inhibitors were used within 4 or 2 weeks of the H. pylori eradication confirmation test, respectively. Result of 245 patients, 145 in the levofloxacin group, and 100 in the clarithromycin group. Patients in either group received medicine for 14 days vs. ten days vs. ten days. Compared to clarithromycin-based therapy, Levofloxacin-based therapy had a higher eradication rate. The eradication of H. pylori was not affected by diabetes or EGD findings, and was not influenced by diabetes or EGD findings. Regardless of diabetes and EGD results, the results from this research show that a levofloxacin-based therapy in the treatment of H. pylori infection for 14 days.

Source link: https://doi.org/10.1186/s13099-022-00502-3

Population pharmacokinetics and dose optimization of intravenous levofloxacin in hospitalized adult patients

"Although levofloxacin has been used for 25 years, there are no pharmacokinetic studies to support levofloxacin dosing in adult patients. " This study sought to develop a pharmacokinetic model of levofloxacin for adult hospitalized patients as well as identify dosing strategies that meet the pharmacokinetic/pharmacokinetic target for maximum success. MIC u2265 1 mg/L: An area under free concentration curve to MIC u2265 80 was hardly reached for pathogens with MIC u2265 1 mg/L, according to our simulation. Patients with increased eGFR were seen with Pseudomonas aeruginosa and Streptococcus pneumoniae, according to Pseudomonas aeruginosa and Streptococcus pneumoniae.

Source link: https://doi.org/10.1038/s41598-022-12627-1

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