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Leukaemia - DOAJ

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Last Updated: 27 July 2022

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Mechanisms of Resistance and Implications for Treatment Strategies in Chronic Myeloid Leukaemia

Mutation in the BCR (ABL1 oncogene): The main aim of chemotherapy for CML has been to reduce the activated BCR's specificity and potency of TKIs to reduce the BCR's activation. Alternative survival signalling, which may lead to BCR::ABL1-independence resistance, can be a promising strategy for eliminating chronic leukaemic cells and ultimately increasing the response rate in CML patients.

Source link: https://doi.org/10.3390/cancers14143300


Disease Burden, Risk Factors, and Trends of Leukaemia: A Global Analysis

About 22. 5 percent of all new cancer cases and 38 percent of cancer-related deaths in Leukaemia stood for about 2. 5% of all new cancer incidences and 38 percent of cancer-related mortality. From GLOBOCAN, CI5, WHO mortality registry, NORDCAN, and SEER, we gathered incidence and mortality of leukaemia. To determine the age-standardised prevalence of lifestyle and metabolic risk factors, we searched the WHO Global Health Observatory data repository for the age-standardised prevalence of lifestyle and metabolic risk factors. We analyzed the trends by estimating Average Annual Percentage Change from Joinpoint regression. Leukaemia's prevalence and mortality were correlated with Human Development Index, Gross Domestic Products per capita, prevalence of smoking, physical fitness, overweight, obesity, and hypercholesterolaemia at the national level. However, an increasing incidence of leukaemia in Germany, Korea, Japan, Canada, and the United Kingdom was discovered in Germany, Korea, Japan, Canada, and the United Kingdom, although mortality in the Philippines, Ecuador, Belarus, and Thailand increased. More radical lifestyle changes should be introduced to combat leukaemia's increasing trends in regions that follow these trends.

Source link: https://doi.org/10.3389/fonc.2022.904292


P neumocystis jirovecii-associated immune reconstitution inflammatory syndrome-like phenomenon in a child with leukaemia: a case report and literature review

Detailed information about immunological disorders in patients with AIDS receiving antiretroviral therapy to resurrect immune function, resulting in functional impairment of multiple organs. During immune recovery, non-AIDS immunosuppressed hosts may also have similar symptoms to IRIS. Following treatment with Granulocyte Colony-Stimulating Factor, sulfamethoxazole, and caspofungin, an acute lung disease epidemic was identified in a short period, as well as an increasing leukocyte count. Conclusions The rapid deterioration of pulmonary lesions in the process of blood transplant and immune reconstitution of patients with acute lymphocytic leukaemia infected with Pneumocytecii should raise suspicion of IRIS-like reactions in patients with acute lymphocytic leukaemia. In further studies, the timing, dose, and length of glucocorticoids therapy, as well as the effects of high-dose methylprednisolone pulse therapy on patient prognosis should be investigated.

Source link: https://doi.org/10.1186/s12887-022-03441-9


DNA methyltransferase-1 in acute myeloid leukaemia: beyond the maintenance of DNA methylation

DNMT1 has been identified as a therapeutic target and a regulator of therapy resistance in solid tumours, increasing research into solid tumours has shown that it is both a therapeutic target and a source of therapy resistance; however, it is unclear if DNMT1 is a key regulator in acute myeloid leukaemia and how it works.

Source link: https://doi.org/10.1080/07853890.2022.2099578


Knowledge and awareness of leukaemia and its risks among the population of Saudi Arabia

The aim of this research is to look at the public knowledge of leukaemia in Saudi Arabia. Using various online platforms, a survey questionnaire using a link was distributed randomly to all the adult population using various web sites by adopting snow-ball sampling methods, resulting in a final sample of 800 participants included in this research. Compared to male, older, and less educated participants respectively, female, young and educated participants had higher knowledge of leukaemia, its types and signs. Conclusion: This report reveals that for deploying cancer awareness campaigns in Saudi Arabia, a systematic and strategic approach is required.

Source link: https://doi.org/10.1016/j.imu.2022.100971


Metabolic plasticity in blast crisis-chronic myeloid leukaemia cells under hypoxia reduces the cytotoxic potency of drugs targeting mitochondria

We investigated mitochondrial membrane potential, mitochondrial mass, glucose uptake, glucose uptake, and CPote of arsenic trioxide, mitochondrial mass, vitrosis, glucose uptake, and CPote, CCCP, vincristine, Mdivi1, and dichloroacetic acid in CML BC cells K562 under hypoxia using flow cytometry and gene expression from the GEO database. Following 72 h of hypoxia, approximately 60% of untreated cells were killed after 72 h under hypoxia, but paradoxically, all drugs but ATO rescued cells and increased survival rates to nearly 90%. With increased MM, blockage mitophagy can be achieved with either VCR or Mdivi1, or increasing mitochondrial biogenesis with VPA enhanced cell biogenesis. In 113 transcriptomes from CML patients, a 25-gene MP-signature of BC-K562 cells under hypoxia detected BC cases. Instead of cytotoxic, effect of drugs targeting mitochondria and MRCSR, we concluded that the hypoxic atmosphere prompted a MP change exhibited by DEG, rather than cytotoxic, effect of drugs targeting mitochondria and MRCSR.

Source link: https://doi.org/10.1007/s12672-022-00524-y


A Ten Year Descriptive Study of Adult Leukaemia at Al-Jomhori Teaching Hospital in Sana'a, Yemen

We reviewed the results of 702 adult patients with leukaemia who were newly diagnosed between October 1999 and October 2009 at the referral haematology center in Sanau2019a, according to type of leukaemia, age, sex, geographic location, and time of diagnosis. Acute Myeloid Leukaemia was found to be the most common followed by Chronic Myeloid Leukaemia, Acute Lymphoid Leukaemia, and Chronic Lymphoid Leukaemia, respectively. Males and females had almost identical prevalence of AML and CML, but males had significantly higher incidences of ALL and CLL. Conclusions: The pattern of adult leukaemia in Yemen is different from that seen in western countries, which could be attributed to different environmental exposures.

Source link: https://doi.org/10.20428/YJMS.8.1.1


Bone Marrow Aging and the Leukaemia-Induced Senescence of Mesenchymal Stem/Stromal Cells: Exploring Similarities

It has been shown that instructional signals from different leukemic cells are delivered to stromal cells to restructure the bone marrow into a specialized leukemic niche. We'll explore the relationship between BM ageing and cell senescence, as well as the role that these processes play in leukaemia transition. One would expect that bone marrow alterations would also have particular changes, making it impossible to envision a joint therapeutic use due to the specificity of the genetic disorders present in leukaemia. We've tried to recapture coincident features present in BM stromal cells during aging and senescence, acute myeloid leukaemia, with high incidence in elderly people, and B-acute lymphoblastic leukaemia, mainly a childhood disease.

Source link: https://doi.org/10.3390/jpm12050716

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions