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Legionnaires' Disease - Europe PMC

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Last Updated: 16 November 2022

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Impacts of weather and air pollution on Legionnaires’ disease in Switzerland: a national case-crossover study

The number of cases of Legionnaires'u2019 disease has increased dramatically in Switzerland and abroad over the past decade. Methods We performed a series of studies based on the Swiss LD notification information from 2017 to 2021, based on the Swiss LD notification data from 2017 to 2021. We used an ecological framework to find environmental determinants of case frequency at the district level in the second instance. To find short-term correlations between seven weather variables and LD occurrence, we used a case-crossover approach with distributed lag non-linear models on third and fourth. Large-scale causes, such as weather and air pollution, had the largest correlation with LD frequency in the ecological model. The case-crossover study revealed a strong correlation of elevated daily mean temperature and mean daily vapour pressure 6-14 days before LD occurance. The relationship between air pollution and LD and weather interplay should be investigated further.

Source link: https://europepmc.org/article/PPR/PPR563681


Legionnaires’ disease in Switzerland: Rationale and study protocol of a prospective national case-control and molecular source attribution study ( SwissLEGIO )

Switzerland has one of Europe's highest annual Legionnairesu2019 disease notification rates. In Switzerland, the SwissLEGIO national case-control and molecular source attribution study investigates risk factors and infection sources. In questionnaire-based interviews, risk factors for LD are assessed. Legionella spp. is a member of the Clinical and Environmental Legionella spp. To find infection sources and the occurrence and virulence of various Legionella spp. Direct comparison of sero- and sequence types, core genome multilocus sequencing types, and single nucleotide polymorphisms between clinical and environmental isolates are used to investigate disease sources and virulence of various Legionella spp. The SwissLEGIO research develops in combining case-control and molecular typing methods for source attribution outside of an outbreak setting. The study provides a unique platform for national Legionellosis and Legionella research and is carried out in an inter- and transdisciplinary collaborative research collaboration approach involving a number of national and international regulatory stakeholders.

Source link: https://europepmc.org/article/PPR/PPR563720

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions