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Lactic Acid - Crossref

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Last Updated: 11 May 2022

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Process-Induced Morphology of Poly(Butylene Adipate Terephthalate)/Poly(Lactic Acid) Blown Extrusion Films Modified with Chain-Extending Cross-Linkers

In an extrusion direction and a transverse direction, the morphology of unmodified and modified films made with blown film extrusion is investigated. Although FTIR findings indicated that the CECLs influence the PBAT/PLA blend's molecular weight, SEM analysis of the fracture surfaces of blown extrusion films revealed their significant effect on the morphology that occurred during the processing revealed only modest peak shifts, indicating that the CECLs modify the PBAT/PLA mixture's molecular weight. Rather than spherical PLA islands being reduced into long fibrils, which would devolve into chains of elliptical islands if cooled slowly, if cooled slowly, due to a mixture of shear and elongation deformation during blown film extrusion.

Source link: https://doi.org/10.3390/polym14101939


Identification of Predominant Lactic Acid Bacteria Associated With Kunun-zaki and Kindirmo a Traditional Fermented Food of Nigeria

Human intestinal flora is extremely diverse, with lactic acid bacteria living as part of the most common gut microbes that promote host health. In the case of probiotic and bacteriocin respectively, the use of lactic acid bacteria as a whole organism or its metabolite is extensive. According to the chart below, 59. 7% were bacilli and 14. 3% were heterofermentative in form, with 68. 75% and 30 percent heterofermentative pathways respectively. Both isolates have the ability to convert glucose to produce lactic acid, but their sensitivity to pH 3 and salt concentrations in 2%, 4%, and 6. 5% varied widely. It was also discovered that traditional fermented foods such as kunun-zaki and kindirmo were a good source of lactic acid bacteria for product manufacturing, starter culture, and probiotic research.

Source link: https://doi.org/10.21203/rs.3.rs-1577271/v1


Antitumor Efficacy of Doxorubicin-Loaded Electrospun Attapulgite–Poly(Lactic-co-glycolic Acid) Composite Nanofibers

Currently, cancer chemotherapeutic drugs have the flaws of high toxicity and low bioavailability, so it is still important to develop novel drug delivery systems for cancer chemotherapy. In addition, the newly released DOX from the nanofibers may have a significant effect on tumor cell formation. The envisioned organic-inorganic hybrid nanofibers may be a promising nanofiber to encapsulate various drugs for improved local tumor therapy applications due to the dramatically reduced burst release profile and improved mechanical tenacity of the ATT/DOX/PLGA nanofibers.

Source link: https://doi.org/10.3390/jfb13020055


Topical Capsaicin in Poly(lactic-co-glycolic)acid (PLGA) Nanoparticles Decreases Acute Itch and Heat Pain

Capsaicin nanoparticles were released in vitro 23% capsaicin within the first hour and had complete release in 72 h. In mice, 24 h post-application Capsaicin nanoparticles penetrated the dermis, resulting in reduced nociceptive behavioral responses to heat and mechanical stimulation. Application in humans resulted in a moderate to moderate burning, dissipating after 3 h. A loss of heat pains of up to 2 weeks was recorded. Capsaicin nanoparticles may be useful in reducing pain and itch associated with inflammatory disorders that are histamine-independence.

Source link: https://doi.org/10.3390/ijms23095275


Biosynthesis and Production of Class II Bacteriocins of Food-Associated Lactic Acid Bacteria

Bacteriocins are ribosomally synthesized peptides produced by bacteria that prevent the growth of similar or closely related bacterial strains. Bacteriocins of Class II are a class of bacteriocins that are heat resistant and do not undergo extensive posttranslational transformation. Both class II bacteriocins, lactic acid bacteria, are widely distributed, and some of them have been used as food preservatives or antibiotic substitutes, with some of them successfully applied as food preservatives or antibiotic alternatives. Bacteriocins class II bacteriocins can be further divided into four subcategories. A particular gene cluster local in the plasmid or chromosome controls the production of class II bacteriocin. Several strains/species of low yield were present in class II bacteriocin-producing LAB, including some strains/species with low yield. A multitude of fermentation variables, including medium size, temperature, and pH, have a major effect on bacteriocin manufacturing, which is mainly strain-specific. In addition, the incorporation of modern biotechnology and genetics with conventional fermentation techniques to increase bacteriocin production will be addressed in this paper.

Source link: https://doi.org/10.3390/fermentation8050217


A Comparative Study on the Aerobic Biodegradation of the Biopolymer Blends of Poly(butylene succinate), Poly(butylene adipate terephthalate) and Poly(lactic acid)

Using the CO2 evolution respirometric technique, the purpose of the present research is to determine the rate and mechanisms of biodegradation of biopolymer blends under controlled composting conditions. The amount of carbon mineralized under home and industrial composting conditions was determined by testing the biopolymer blends of poly blended with poly and PBAT blended with poly by melt extrusion. When compared to home composting conditions, both blends showed higher degradation rates under industrial composting conditions. On the surfaces of the biopolymer blends, SEM revealed that microbial colony formation and disintegration had occurred.

Source link: https://doi.org/10.3390/polym14091894


Functional characterization of α-Gal producing lactic acid bacteria with potential probiotic properties

New research has explored the possibility of misusing the human immune response to glycan -Gal for the diagnosis of multiple infectious diseases. In vivo research using a mouse model was used to determine the immunological response to -Gal by four LAB strains with the highest -Gal concentrations. The amount of anti-Gal IgG was not significant, although the level of anti-Gal IgG was lower in comparison to that elicited by E. Both the prevention and diagnosis of various infectious diseases and probiotic development were shown in this study, which produced -Gal, which may have promising probiotic capacity and can be further investigated in -Gal-focused research for both prevention and treatment of various infectious diseases and probiotic development.

Source link: https://doi.org/10.1038/s41598-022-11632-8


Profound Neonatal Hypoglycemia and Lactic Acidosis Caused by Pyridoxine-Dependent Epilepsy

PDE is a result of PDE's inherited mutations (ALDH7A1 gene mutations resulting in a -aminoadipic semialdehyde deficiency as a cause of PDE) that was not identified until 2005. In > half of patients with classic PDE, Neonatal epileptic encephalopathy is the predominant feature. We present the case of a 13-month-old girl with severe neonatal hypoglycemia, lactic acidosis, and bilateral symmetrical temporal lobe hemorrhages and thalamic changes on cranial MRI. The diagnosis of a novel putative pathogenic missense mutation in the ALDH7A1 gene was confirmed based on elevated urinary -aminoadipic semialdehyde excretion, compound heterozygosity for a known splice mutation c. 834G > A, and a new putative pathogenic missense mutation c. 1192G > C. This case is the first description of a patient with PDE as a result of mutations in the ALDH7A1 gene, causing severe neonatal hypoglycemia and lactic acidosis masquerading as a neonatal-onset gluconeogenesis defect, as a neonatal-onset gluconeogenesis defect.

Source link: https://doi.org/10.1542/peds.2011-0123


Isolation and Characterization of Potential Lactic Acid Producing Bacteria from Fermented Fruit Juice

Because of their ability to produce antimicrobial agents, Lactobacillus species are used as probiotics to prevent human pathogens from killing human pathogens. Specifically, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Bacillus cereus, Salmonella typhi, Salmonella coli, Salmonella typhi, and Shigella boydii were isolated and used as probiotics in this study. Among them, three bacterial isolates of Glucose Yeast Extract media supplemented with calcium carbonate containing acid and clear zones around the colonies. P. aeruginosa, and E. coli were found in the best inhibition zone on pathogens S. aureus, P. aeruginosa, and E. coli in L. plantarum.

Source link: https://doi.org/10.29037/ajstd.759

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions