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"The circular dichroism spectra of d- and l-ARGO7 reached a peak at 228 nm and reversibly responded to pH changes, but were almost unaffected by temperature, ionic strength, and denaturating agents. " Torsion angles showed a very similar distribution at pH 6 and 14 respectively, which was consistent with the similarity of the CD spectra from pH 6 to 14.
Source link: https://doi.org/10.1021/acsmacrolett.7b00492
"In vivo, dietary L-Arg supplementation increased breast and thigh muscle mass, while MS treatment had no discernible effect. In myoblasts from PM muscle, in vitro, L-Arg or sodium nitroprusside, reduced protein synthesis rate, downplayed phosphorylated mTOR/p70S6K, and decreased atrogin-1 and muscle ring finger 1 in myoblasts from PM muscle. Also, blocking the mTOR/p70S6K pathway with rapamycin reduced protein synthesis of the two types of myoblasts; meanwhile, the protein expression of atrogin-1 and MuRF1 levels was limited only in PM muscle myoblasts; whereas, in lymphocytes, PM muscle myoblasts were limited to protein-bound synthesis. In conclusion, the L-Arg/NO/mTOR/p70S6K pathway in chickens raises protein synthesis and muscle growth in fast-twitch glycolytic muscle. Protein turnover is controlled by muscle fiber specificity in a muscle fibre specific manner, underscoring the potential clinical use of fast-twitch glycolytic muscle fibers. ".
Source link: https://doi.org/10.1016/j.aninu.2022.04.010
"The low-salt surimi gels produced by MW had similar physicochemical characteristics as traditional two-stage water bath heating's normal-salt surimi gels. " Arg boosted the water holding capacity and gel strength relative to low-salt surimi gels made solely by TGase alone, enhancing the water holding capacity and gel strength, encouraging the establishment of a more homogeneous and compact three-dimensional gel network. Using the molecular docking simulations, the exact nature of the binding sites between Arg and the myosin heavy chain was estimated. ".
Source link: https://doi.org/10.1016/j.foodchem.2022.133184
Rats' diabetic AD is a disorder that causes neurological disturbances, brain amyloid u03b2 levels, and other relevant biochemical parameters are among the effects of NOS substrate, L-arginine and NOS blocker, NG-nitro-L-arginine methyl ester. In addition, L-arginine raised insulin levels and glucose tolerance. According to the vehicle treated group, L-arginine treatment improved cognitive deficits seen in the Morris water maze experiment, and similar findings were observed in the passive avoidance test. In the HFD + STZ + saline group, predictable variations in Au03b2 levels in hippocampus and cortex had been attenuated in the L-arginine, but not in the L-NAME-treated group. L-arginine may be a potential therapeutic tool to attenuate AD's diabetes-related cognitive impairments.
Source link: https://doi.org/10.26402/jpp.2022.1.01
"Our research, on the other hand, aims to investigate the effects of L-arginine on the development of MG in pubertal mice. " L-arginine, according to a whole-mount staining, can extend the MG duct. In vitro, 0. 4 mM L-arginine could activate the G protein-coupled receptor family C, group 6, or increase the phosphorylation of cell cycle regulatory protein D1 in mMECs, leading to the dissociation of the retinoblastoma tumour suppressor protein 1 (E2F1) transcription factor complex and increasing cell proliferation. In vivo, it was also announced that 0. 1% L-arginine would stimulate the PI3K/AKT/mTOR signalling pathway in pubertal mice's MG. These findings showed that L-arginine promotes MG in pubertal mice via the GPRC6A/PI3K/AKT/mTOR signalling pathway.
Source link: https://doi.org/10.1111/jpn.13730
"The establishment of new blood vessels in the ischemic zone is a basic step that can minimize myocardial infarction-induced complications by at least eliminating hypoxia. " The following groups were randomly divided: Sham, Sedentary control, 3 L-arginine medication, La, n = 10, and High-Intensity Interval Training Plus Larginine supplementation HIIT + La, n = 10. Rats in the training groups underwent high-intensity interval training for 8 weeks, 5 days a week. Subjects in La and HIIT + La groups were given Larginine in drinking water 4 g/L. Following a myocardial ischemia-reperfusion injury in a non-infarcted area, exercise training and L-arginine supplementation increased Cat and GSH activities as well as reduced MDA production. Following myocardial ischemia-reperfusion in the non-infarct zone, the La + HIIT group's percentages were higher than the con group, VEGF, and Ang-1, as well as Ang-1 to Ang-2 ratio following myocardial ischemia-reperfusion in the non-infarct region.
Source link: https://doi.org/10.1007/s12012-022-09752-8
"This research sought to determine the effect of arginine priming on wheat growth and some physiological characteristics of wheat plants grown under normal or drought-stressed conditions. " Soaking wheat grains with arginine stimulates plant growth and reduces the adverse effects of drought stress. Compare to the corresponding control values, arginine, which extended root length, leaves number, shoot fresh weight, root dry weight, chlorophyll a, chlorophyll b, and carotenoids were the most effective treatment to minimize the effects of drought stress on wheat plants. Arginine enhanced the production of soluble sugars, proline, free amino acids, phenols, and flavonoids in wheat plants under normal or challenging conditions. "Ultimately, pretreatment with arginine had a good chance to combat drought stress on wheat plants by promoting physiological and metabolic functions. ".
Source link: https://doi.org/10.3390/plants11091219
"Current coronavirus disease is recognized as a key respiratory and vascular disease leading to acute lung injury, acute respiratory distress syndrome, and severe cases of endothelial dysfunction. " Since endothelial cells are considered the primary barrier against SARS-CoV-2 invasion, it has been speculated that ED is linked to several Covid-19 problems. L-arginine may reduce the risk of ALI by blocking the production of peroxynitrite and suppression of proinflammatory cytokines from alveolar macrophages. SARS-CoV-2 infection can be reduced by various mechanisms, including reduced binding of SARS-CoV-2 and cellular attachment, proliferation and replication of SARS-CoV-2, and prevention of SARS-CoV-2-induced coagulopathy. In conclusion, L-arginine and reported NO have joint and interrelated actions against SARS-CoV-2 infection, which includes antiviral and immunomodulatory effects.
Source link: https://doi.org/10.2174/1389203723666220512104039
Both hypertension and cognitive impairment have been shown to be caused by endothelial dysfunction. " We conducted a clinical trial to see the effects of L-Arginine oral supplementation of hypertensive frail older patients. We found a significant difference in the Montreal Cognitive Assessment test score between the L-Arginine treated group and placebo, according to a follow-up. Moreover, we found that L-Arginine significantly reduces Angiotensin II-induced mitochondrial inflammation in human endothelial cells. Our findings, published in total, indicate that oral L-Arginine supplementation substantially improves cognitive function in frail older adults for the first time. ".
Source link: https://doi.org/10.3389/fcvm.2022.868521
"The effects of exercise supplementation with L-citrulline or L-arginine supplementation are equivocal, and the effects on swimming results are uncertain. " We wanted to see if eight-day supplementation with L-arginine or L-citrulline supplementation could improve 200 m and 100 m freestyle swimming time trials trials's results. Participants in both 200 m and 100 m freestyle swimming time trials in each trial, after blood testing, underwent 30 minutes recovery between trials. Plasma nitric oxide and blood lactate concentrations were determined immediately before and after 200 m and 100 m TTs, respectively. There was no significant difference between the 200 m and 100 m swimming time-trials between the two groups, no significant differences were found between the two groups in 200 meters and 100 m swimming time trials. Time had a major effect on BLa concentration, according to the CDC, but no trial u00d7 group and trial u00d7 group interaction effect was present, with the exception of a single effect of group interaction. These results do not support the use of L-citrulline or L-arginine supplementation as ergogenic aids for swimming success.
Source link: https://doi.org/10.3390/ijerph19084462
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