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"Nitric oxide is a key regulator of arterial autoregulation and is instrumental in pathophysiological changes in acute neurological disorders. " Nitric oxide synthases from the amino acid L-arginine creates Nitric oxide. This review explores the role of L-arginine metabolism in patients suffering from acute and chronic neurological disorders that often necessitate neuro-intensive care therapy.
Source link: https://europepmc.org/article/MED/34916417
"This research investigated the ability of l-arginine and l-lysine to prevent the adverse effects of freezing on myofibrillar proteins extract in porcine Longissimus lumborum's structure and solubility. " In addition, the SDS-PAGE analysis found that l-arginine and l-lysine could reduce the appearance of bands at around 150 kDa. Both l-arginine and l-lysine, as well as the oxidation of their polar amino compounds, which ultimately contributes to their superior solubility, are shown in this report.
Source link: https://europepmc.org/article/MED/35661602
"Here, we've investigated the role of L-arginine and polyamines in the transcriptional regulation of genes involved in arginine metabolism and pro-inflammatory reaction in murine BALB/c macrophages. " Supplementation with L-arginine is ineffective to regulate macrophage gene expression and infection, according to our researchers. Polyamine supplementation increased nitric oxide synthase and nitric oxide production, as well as other macrophage enzymes. In both uninfected and L. amazonensis infected macrophages, Putrescine supplementation raised transcript levels of polyamine metabolism-related genes Arginase 2, Spermidine synthase, and Spermine synthase. Putrescine's increased Nos2 expression without resulting in no production, despite no production, while L-arginine plus spermine resulted in the production of NO in uninfected macrophages. Besides, L-arginine supplementation reduced the production of Il-1b during infection, and L-arginine or L-arginine plus putrescine raised Mcp1 at 24 hours of infection. "Our results showed that the polyamines were transferred L-arginine-metabolism related-genes on BALB/c macrophages and affect disease by L. amazonensis. ".
Source link: https://europepmc.org/article/PPR/PPR499278
"Amino acids have been shown to have a role in the formation of mammary glands. " Hence, our research intends to investigate the effects of L-arginine on pubertal mice's MG production. L-arginine, according to a whole-mount staining, can prolong the MG duct's length. In vitro, 0. 4 mM L-arginine could activate the G protein-coupled receptor family C, group C, subtype A/phosphoinositide 3-kinase 4E binding protein 1 in mMECs and boost cell proliferation by increasing the phosphorylation of retinoblastoma tumor suppressor protein D1 in mMECs and increasing cell proliferation by triggering the dissociation of the retinoblastoma These findings revealed that L-arginine promotes MG formation in pubertal mice via the GPRC6A/PI3K/AKT/mTOR signalling pathway.
Source link: https://europepmc.org/article/MED/35616019
"However, the effect of M. koenigii leaves on N u03c9 is unknown" is unclear. " The aim of the present study was to investigate the effect of M. koenigii leaves as tea on L-NAME-induced liver dysfunction. Methods Two versions of curry tea were introduced; one was made entirely from leaves of M. koenigii's leaves, while the other was created with thaumatin-rich aril obtained from Thaumatococcus danielii Benth's seeds. The hepatoprotective, antioxidant, and anti-lipidemic activity of aqueous curry tea extracts in rats did not significantly reduce or potentiate. Practical applications The report reveals that non-selective inhibition of nitric oxide in rats impaired liver function and formulated curry tea varieties interfered with the ability of L-NAME to inhibit NO synthesis, which was associated with reduced hepatic dysfunction in rats.
Source link: https://europepmc.org/article/MED/35608322
"The development of new blood vessels in the ischemic zone is a key measure that can minimize myocardial infarction-induced injury by mitigating hypoxia. " This paper was designed to investigate the cardioprotective effects of high-intensity interval training preconditioning and L-arginine supplementation on myocardial ischemia-reperfusion-induced angiogenesis and oxidative stress in myocardial ischemia-reperfusion-induced angiogenesis and oxidative stress. 50 male rats were randomly divided into the following groups: Sham, Sedentary Control, 3 L-arginine treatment La, n = 10, and High-Intensity Interval Training Plus L-arginine supplementation HIIT + La, n = 10. Rats in the training groups underwent high-intensity interval training for 8 weeks, 5 days a week. Subjects in La and HIIT + La groups were given L-arginine in drinking water 4 g/L. Following an ischemia-reperfusion arrest in a non-infected area, exercise preparation and L-arginine supplementation improved Cat and GSH activities, as well as reduced MDA activity.
Source link: https://europepmc.org/article/MED/35598222
"However, the effects of L-arginine on blood fluidity after exercise remain unclear. " In vitro, we investigated the causes of decreased blood fluidity after high-intensity training, as well as whether L-arginine causes exercise-induced blood fluidity impairment. Methods Ten healthy male participants completed 15 minutes of ergometer exercise at 70% of their peak oxygen uptake levels. On the microchannel terrace, we measured the blood passage time, percentage of blocked microchannels, and the number of adherent white blood cells on Kikuchi's microchannel system. The L-arginine-induced decrease in blood passage time was blocked by L-NMMA, which resulted in the L-arginine-induced decrease in blood passage time. ".
Source link: https://europepmc.org/article/MED/35599472
"Under microwave irradiation, the present study revealed that low-salt surimi gels could be made using a combination of l-arginine and transglutaminase. The low-salt surimi gels produced by MW had similar physicochemical characteristics as conventional two-stage water bath heating's conventional low-salt surimi gels. Arg increased the water holding capacity and gel strength in comparison to low-salt surimi gels that contain TGase alone, as well as promoted the establishment of a more homogeneous and compact three-dimensional gel network. ".
Source link: https://europepmc.org/article/MED/35640331
"In severe cases, primary coronavirus disease is thought to be a primary respiratory and vascular disease contributing to acute respiratory disease, acute respiratory distress syndrome, and endothelial dysfunction. " Since endothelial cells are considered to be the main barrier against SARS-CoV-2 invasion, it has been reported that ED is connected to several Covid-19 disorders. With subsequent vaping and tissue hypoxia, SARS-CoV-2-indued ED contributes to endotheliosis and thrombosis due to endothelial nitric oxide inhibition. L-arginine may reduce the risk of ALI by inhibiting the production of peroxynitrite and suppression of proinflammatory cytokines from alveolar macrophages. "Rear-CoV-2 -inhibition of SARS-CoV-2 infection may lead to the reduction of NO by L-arginine in SARS-CoV-2 formation and replication, as well as prevention of SARS-CoV-2-induced coagulopathy. ".
Source link: https://europepmc.org/article/MED/35549865
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