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"The effects of L-arginine treatment of ischemic hindlimb in vivo were determined"; results: "The enactment of a retencing of CaP/peNOS increased the eNOS expression was then validated as a NO substrate catalyzed by eNOS was later investigated as a NO substrate enriched by eNOS. In addition, R-CaP/peNOS treated HUVECs showed the highest NO release, cell migration, tube formation, and lowest inflammatory levels among the CaP/peNOS and R-CaP/peNOS groups. Conclusion: Key words: Gene expression, nitric oxide, L-arginine, calcium ions addition, and angiogenesis can be attributed to the highest eNOS-derived NO production. We also established the benefits of R-CaP/PENOS in raising blood reperfusion in hindlimb ischemia mice by accelerating angiogenesis and lowering inflammation, which can be attributed to the highest eNOS-derived NO production.
"The proper balance of the amino acids arginine and lysine in chicken feed is particularly important. " The purpose of this research was to investigate the effects of a L-arginine-to-Lysine HCl ratio on growth and ileum morphology of native chickens aged 2-14 weeks old. Group T3 and T6 had the highest feed intake, while Group T6 had the highest body weight and body weight gain rate compared to Group T6. For ileum morphometry, the highest villus height occurred in Groups T2, T3, T5, and T6; and Group T6 had the highest crypt depth and villus width, according to the highest crypt depth and villus width. Conclusion: The highest percentage of arginine-lysine was correlated with the largest rise in native chicken feed intake, body weight gain, feed conversion, and carcass weight, as well as villus height and width in the ileum.
Source link: https://doi.org/10.14202/vetworld.2022.1365-1372
"The current research sought to determine whether combined training with or without L-arginine ingestion had an effect on the circulation of adropin, VEGFR-2, and nitric oxide in postmenopausal women with hypertension. " Conclusions: The obtained results showed a dramatic rise in the serum levels of adropin and VEGFR-2 in T and TL groups in comparison to those in P and L groups. In addition, systolic blood pressure dropped significantly in T, L, and TL groups in comparison to those in P group and in the TL group compared to L and T groups. On the other hand, we observed a dramatic decline in diastolic blood pressure in L, T, and TL groups compared to those in the P group; the same pattern was observed in the TL group relative to the L group. In addition, L-arginine supplementation was found to be correlated with an increase in overall training effect in decreasing blood pressure. ".
Source link: https://doi.org/10.30476/whb.2022.94390.1164
"Larginine has been shown to reduce ischemia and reperfusion injury. " When perfused with l-arginine, we predict that explanted intestinal segments from rats will lead to reduced susceptibility to ischemic injury. Methods: 45 small intestinal segments were extracted from male Sprague-Dawley rats and attached to an ex vivo intestinal perfusion unit. We conducted a series of experiments with intraluminal perfusion using both l-arginine and N-nitroarginine methyl ester, an inhibitor of the nitric oxide pathway, u2013 arginine. In comparison to intestinal segments perfused without l-arginine, intestinal segments perfused with l-arginine had drastically reduced visibility over time.
Source link: https://doi.org/10.1016/j.tpr.2022.100096
"Defatted walnut powder extract, the remnants of walnut kernel extract for oil, has the ability of hypertriglyceridemia. " Rats' serum cholesterol, triglyceride, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol were all significantly reduced after treatment with DWPE, as compared to the model group. Therefore, DWPE will have a preventive role in the development of hyperlipidemia acute pancreatitis to a certain degree by lowering pancreatic cell injury, pancreatic oxidative stress level, and the amounts of pancreatic digestive enzymes and inflammatory factors. ".
Source link: https://doi.org/10.1590/fst.19722
Both hypertension and cognitive dysfunction have been shown to be caused by endothelial dysfunction. " The effects of L-Arginine oral supplementation by four weeks on global cognitive function in hypertensive frail older patients need to be determined by a scientific trial. At a follow-up, we discovered a significant difference in the Montreal Cognitive Assessment test score between the L-Arginine treated group and placebo. Moreover, we found that L-Arginine significantly reduces Angiotensin II-induced mitochondrial oxidative stress in human endothelial cells. Clinical Trial Registration www. clinicalTrials. gov's identifier: NCT04962841" says in conclusion, our results show that oral L-Arginine supplementation significantly raises cognitive dysfunction in frail older adults for the first time.
Source link: https://doi.org/10.3389/fcvm.2022.868521
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