Advanced searches left 3/3

Ketoconazole - Springer Nature

Summarized by Plex Scholar
Last Updated: 13 April 2022

* If you want to update the article please login/register

Biosynthesis of TiO_2 nanoparticles as a suitable photocatalyst for degradation of ketoconazole: characterization, efficiency, toxicity evaluation and degradation pathways

According to BET's scale, the average surface area, mean pore diameter, and pore size distribution of the biosynthetic TiO_2-NPs was 6,24 m2/g, 8. 86 nm, and 1. 21 nm, respectively. 60 min. and 60 min. under the ideal conditions of [TiO_2-NPs] = 1600 mg/L, pH 3. 5, T = 30 °C,] = 120 mg/L, and 60 min. [H_2O_2] = 120 mg/L, 60 min. The photodegradation of KNZ is consistent with the pseudo-first-order model's rate constant of 0. 271 1/min, according to the kinetics data analysis. In addition, the KNZ photocatalytic degradation process was investigated by measuring the toxicity of the solution, the results of which revealed that the toxicity of the KNZ solution decreased significantly after photocatalytic degradation. To demonstrate the degradation mechanism, liquid chromatography coupled with mass spectrophotometry was found in the intermediate products resulting from the KNZ degradation process.

Source link: https://doi.org/10.1007/s10854-022-07774-0


Ketoconazole loaded quaternized chitosan nanoparticles-PVA film: preparation and evaluation

By tube dilution technique, the entrapment effectiveness of different batches of ketoconazole loaded QCSNPs were determined from 80 to 90 percent. The developed drug loaded nanoparticles were mixed with PVA to produce medicated PVA films carrying KCZ-QCSNPs and investigated the release behavior. In a PBS solution, the release of KCZ-QCSNPs, KCZ-QCSNPs-PVA film, and KCZ-PVA film were carried out. To investigate the release behavior, the in vitro release data was embedded in a variety of release kinetic models.

Source link: https://doi.org/10.1007/s00289-020-03500-0

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions