Advanced searches left 3/3

Ketoconazole - PubAg

Summarized by Plex Scholar
Last Updated: 15 October 2021

* If you want to update the article please login/register

Ecotoxicological effect of ketoconazole on the antioxidant system of Daphnia similis

The occurrence of arising pharmaceutical toxins present in water environments revealed to be a current ecological trouble still without evident remedy. Here, ecotoxicological examinations were conducted, concentrating on the analysis of the effects of ketoconazole on the antioxidant system of the design body Daphnia similis. A decline in GST and APX task was observed triggered by KTZ exposure, respectively 79. 2% and 24. 4%. On the other hand, it was observed an increase of 27% in CAT task.

Source link: https://pubag.nal.usda.gov/catalog/7377991


Ketoconazole and Ketoconazole/β-cyclodextrin performance on cotton wound dressing as fungal skin treatment

Here, a cotton wound clothing was prepared with control release of Ketoconazole to kill skin fungus. The medication release, antimicrobial activities versus C. albicans, A. n...., E. coli and S. aureus and cell cytotoxicity were studied. KZ surprisingly responded with the cotton in the set treatment possibly as a result of both active chlorine teams, high temperature and reasonably lengthy treatment time. Great antifungal tasks and slow-moving release reported for the KZ dealt with material, however KZ/ β-CD filled more on the material with regular and sluggish launch for longer time.

Source link: https://pubag.nal.usda.gov/catalog/6887772


Amelioration of ketoconazole in lipid nanoparticles for enhanced antifungal activity and bioavailability through oral administration for management of fungal infections

Ketoconazole is a broad-spectrum imidazole antifungal agent, utilized in opportunistic systemic fungal infection treatment. The purpose of the investigation was the growth and characterization of packed lipid nanoformulations such as solid lipid nanoparticles and nanostructured lipid carriers that might improve oral bioavailability and enhance antifungal task through oral distribution. Enhanced KZ-LNFs were evaluated for in vitro antifungal efficiency versus Candida albicans, and bioavailability studies were carried out in Wistar rats by solitary oral administration contrasted with KZ suspension as control formula. The enhanced KZ-SLN formula revealed particle dimension and entrapment effectiveness of 210. 9 ± 3. 4 nm and 84. 8 ± 1. 5 % contrasted to 167. 8 ± 5. 8 nm and 95. 3 ± 2. 0 % for maximized KZ-NLC formula. In general, SLN and NLC solutions considered as alternative delivery vehicles for KZ oral administration in fungal infections treatment.

Source link: https://pubag.nal.usda.gov/catalog/7080666


Combination therapy with azathioprine, cyclosporine and ketoconazole in a dog with concurrent pemphigus foliaceus and hyperadrenocorticism – Case report

A 10-year-old, spayed women Shih Tzu pet dog presented with a history of progressive erythema and several crusts establishing 85 days formerly. Histopathological findings demonstrated subcorneal pustules with acantholytic cells and undamaged neutrophils. On the basis of these findings, we identified pemphigus foliaceus with simultaneous HAC. To the finest of our expertise, this is the first case record defining simultaneous PF and HAC in a dog. Combination therapy with azathioprine, customized cyclosporine and ketoconazole was effective, and need to be considered for pet dogs diagnosed with simultaneous autoimmune diseases and HAC.

Source link: https://pubag.nal.usda.gov/catalog/7255476


Clinical, clinicopathologic, and hepatic histopathologic features associated with probable ketoconazole-induced liver injury in dogs: 15 cases (2015–2018)

PETS 15 dogs with presumed ketoconazole-induced liver injury that underwent liver biopsy. The most usual breed was Cocker Spaniel. All canines obtained ketoconazole to treat cutaneous Malassezia infections. Median daily ketoconazole dose was 7. 8 mg/kg, PO. Treatment duration varied from 0. 3 to 100 cumulative weeks; 6 pets were dealt with for ≤ 10 days. All dogs established high serum liver enzyme tasks. 5 pet dogs created persistent hepatitis, including 3 with pyogranulomatous inflammation. Of the 10 pet dogs reported to have passed away at last follow-up, survival time after illness onset ranged from 0. 5 to 165 weeks, with 7 pets dying of liver-related causes. CONCLUSIONS AND CLINICAL RELEVANCE Findings for dogs with hepatotoxicosis circumstantially associated with ketoconazole treatment suggested proactive tracking of serum liver enzyme activities is recommended prior to and sequentially after initiation of such treatment.

Source link: https://pubag.nal.usda.gov/catalog/7297039


Photocatalytic degradation of ketoconazole by Z-scheme Ag3PO4/graphene oxide: response surface modeling and optimization

Ketoconazole is an imidazole fungicide which is generally utilized as pharmaceutical and health care products. The present research study investigated ketoconazole photocatalytic degradation making use of Ag ₃ PO ₄/ graphene oxide. Ag ₃ PO ₄/ GO and Ag ₃ PO ₄ as visible light-driven photocatalysts was synthesized making use of the in situ growth method. Destruction of ketoconazole at the focus of 1-- 20 mg/L in aqueous options was enhanced in the visibility of Ag ₃ PO ₄/ GO nanocomposite with the dose of 0. 5-- 2 g/L, contact time of 15-- 20 min, and pH of 5-- 9 utilizing response surface area methodology. Under the maximized problems, the Ag ₃ PO ₄/ GO catalyst accomplished a photocatalytic performance of 96. 53% after 93. 34 minutes. The outcomes indicated that the Ag ₃ PO ₄/ GO nanocomposite exhibited greater photocatalytic task for ketoconazole degradation, which was 2. 4 times that of pure Ag ₃ PO ₄. The high photocatalytic task, acceptable reusability, and excellent aqueous stability make the Ag ₃ PO ₄/ GO nanocomposite an encouraging nanophotocatalyst for photocatalytic deterioration of azoles contaminants.

Source link: https://pubag.nal.usda.gov/catalog/6819702


Presumptive iatrogenic hypoadrenocorticism induced by high‐dose ketoconazole administration in a dog

After a short course of corticosteroid treatment, an ACTH stimulation examination was repeated and pre‐ACTH cortisol concentration was within the recommendation variety, and the post‐ACTH cortisol concentration was gently raised. The temporal organization in between return of ample adrenocortical cortisol manufacturing and discontinuation of ketoconazole brought about the conclusion that the pet had developed iatrogenic HA additional to ketoconazole treatment.

Source link: https://pubag.nal.usda.gov/catalog/6704335


Co-exposure to ketoconazole alters effects of bisphenol A in Danio rerio and H295R cells

This study investigated the effects of ketoconazole on the responses caused by bisphenol A in zebrafish and in human adrenocarcinoma cells. After exposure to BPA alone or blended with KCZ for 21 d, egg production, relative tissue weights, sex hormonal agent levels, cytochrome P450 3a task, and transcriptions of genes connected to CYP vitellogenesis, steroidogenesis, and metabolic process were identified in zebrafish. Male fish were extra conscious the negative effects of BPA than females, and the existence of KCZ potentiated the BPA-induced estrogenic responses in the male and anti-estrogenic responses in the women fish. In male zebrafish revealed to BPA, a substantial reduction in egg number and relative gonad weight, a rise in 17β-estradiol to testosterone ratio, and an upregulation of vtg, erα, and cyp19a genetics were observed. Co-exposure to BPA and KCZ in H295R cells enhanced E2 and reduced T production.

Source link: https://pubag.nal.usda.gov/catalog/6543573


Development of nose-to-brain delivery of ketoconazole by nanostructured lipid carriers against cryptococcal meningoencephalitis in mice

Cryptococcus neoformans-mediated meningoencephalitis is an important infectious problem of the human central nerves. We demonstrated that fluorescent-dye-loaded NLCs efficiently uptake into the cytoplasm of enveloped C. neoformans cells. In contrast with existing antifungal medications, the ketoconazole -NLCs show dramatically boosted antifungal activity against C. neoformans in vivo under various growth conditions. In mouse brain cells, keto-NLCs revealed dramatically improved antifungal task when carried out intranasally, drastically moistening the C. neoformans problem. Taken with each other, NLCs not only boost the ketoconazole penetration performance against capsulated C. neoformans cells, but also boost the efficacy of antifungal medications.

Source link: https://pubag.nal.usda.gov/catalog/6594051


Oxythiamine improves antifungal activity of ketoconazole evaluated in canine Malassezia pachydermatis strains

Records suggest that stress of M. pachydermatis immune to commonly utilized antifungal agents might be emerging. PURPOSES: The synergistic result of oxythiamine and ketoconazole was evaluated utilizing a reference stress and field isolates of M. pachydermatis. The antifungal impacts of hydrogel formulations were determined by a plate diffusion approach. All M. pachydermatis stress revealed greater vulnerability to KTC. Hydrogels that contained OT at a focus of 10 × 10 ³ or 20 × 10 ³ mg/L and KTC at the concentration of 0. 1 × 10 ³ mg/L showed a more powerful effect than a readily offered item with KTC alone. CONCLUSIONS AND CLINICAL IMPORTANCE: Synergy of these medications might permit successful topical treatment which makes use of reduced doses of KTC without changing its restorative effectiveness. Hydrogel formulas confirmed to be attractive medication carriers for potential topical usage.

Source link: https://pubag.nal.usda.gov/catalog/6206109

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions