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Keloid - PubMed

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Last Updated: 24 January 2023

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PI3K/AKT pathway promotes keloid fibroblasts proliferation by enhancing glycolysis under hypoxia.

In keloid fibroblasts under hypoxic conditions, our previous research showed reduced glucose metabolism and enhanced phosphorylation of the PI3K/AKT pathway. However, it is unclear if the PI3K/AKT pathway promotes KFb cell function by regulating glucose metabolism under hypoxic conditions. In addition, cell proliferation was impaired when KFb were treated with both SC79 and 2-deoxy-d-glucose, relative to the SC79 group. Our findings showed that the PI3K/AKT pathway promotes proliferation and arrests apoptosis in KFb under hypoxia by regulating glycolysis, reducing glycolysis, indicating that the PI3K/AKT signalling pathway may be a therapeutic target for keloids.

Source link: https://doi.org/10.1111/wrr.13067

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions