Iso- - Europe PMC

An ISO-certified genomics workflow for identification and surveillance of antimicrobial resistance.

A long-standing challenge to clinical and public health microbiology has been realizing that genomics can help identify and monitor antimicrobial resistance. AMR gene analysis by DNA-based AMR gene expression is shown here. We're here to report the development and validation of abritAMR, an ISO-certified bioinformatics platform for genomics-based bacterial AMR gene detection. The abritAMR platform integrates NCBI's AMRFinderPlus, as well as additional features that classify AMR determinants into antibiotic classes and provide customized reports. 864 Salmonella spp. 's genome has been compared to genomic analyses of phenotype for 864 Salmonella spp. The AMR tool and validation datasets are freely available to assist laboratories everywhere in harnessing the benefits of AMR genomics in scientific research.

Source link: https://europepmc.org/article/MED/36599823

A possible feedback between dynamics and thermodynamics through the background moisture in dictating the ISO rainfall over the Bay of Bengal

According to this report, the ISO rainfall patterns in the south Bay of Bengal strengthen before they re-strengthen over the north Bay of Bengal. The ISO rainfall system is determined by the convergence of background moisture caused by the ISO wind disturbances. We continue to investigate the rainfall pattern since previous research shows that barotropic vorticity causes the planetary Boundary Layer convergence is triggered by barotropic vorticity. We find that although vorticity tilting aids in the production of ISO vortex's positive tendency, it is the vorticity stretching that increases the PBL convergence and hence the ISO rainfall over the NBoB. We hypothesize that the lower rainfall anomalies in the SBoB result from lower background column relative humidity and moisture, which do not encourage the initial dynamic perturbations to grow as quickly as they do in an environment with greater background relative humidity and moisture.

Source link: https://europepmc.org/article/PPR/PPR590779

Effect and mechanism of safranal on ISO-induced myocardial injury based on network pharmacology.

In recent studies, Safranal has provided excellent myocardial protection, but the mechanism of its involvement in myocardial injury caused by sympathetic hyperactivation remains unclear. The aim of this review was to determine whether safranil can safely reduce isoproterenol-induced myocardial injury in rats and H9c2 cells, as well as announcing its pharmacological intervention and goal in preventing sympathetic hyperactivation. Subcutaneous injection of ISO was used to build an in vivo model of myocardial disease, and ISO's in vitro model of H9c2 cell injury was created by ISO. According to the findings of network pharmacological and molecular docking, the process by which safranal relieves myocardial injury can be closely related to the TNF signaling pathway, is closely linked to the TNF signaling pathway, and safranal plays a role in regulating the TNF signaling pathway's key targets.

Source link: https://europepmc.org/article/MED/36586525

Research on the relationship between the scattering contribution and physical factors of the reference radiation regulated by ISO 4037-1.

The minimum dimension of a gamma radiation reference field was not clearly defined in the latest edition of ISO 4037-1:2019, which makes the development of a minitype gamma reference radiation field lacks scientific credibility. ISO 4037-1-regulated reference radiation's scattering contribution and physical reasons of the reference radiation was investigated by this paper. By the PSO method, the minimum dimension of collimated reference radiation field is obtained. Then the minimum dimension of collimated reference radiation field is obtained. The minimum size of the radiation field obtained by Cs-137 is 153 cm u00d747 cm,u00d747 cm.

Source link: https://europepmc.org/article/MED/36580450

Macrophage migration inhibitory factor (MIF) inhibitor iSO-1 promotes staphylococcal protein A-induced osteogenic differentiation by inhibiting NF-κB signaling pathway.

Methods In the present study, staphylococcal protein A -treated rat bone marrow mesenchymal stem cells were used to create cell models of osteomyelitis. MIF inhibitor methyl ester of -3-4,5-hydroxypropyl ester of osteomyelitis cell culture was used to determine MIF expression levels and cell models of osteomyelitis progression toward osteogenic differentiation in rats and cell models of osteomyelitis. MIF expression in rat and cell models of osteomyelitis was upregulated, and it was later shown by the GSE30119 database that the expression level of MIF was also significantly elevated in patients with osteomyelitis. Conclusion ISO-1 and MIF knockdown may reverse osteogenic differentiation in the rBMSCs model of osteomyelitis by blocking the NF-u03baB signaling pathway, providing a potential target for osteomyelitis treatment.

Source link: https://europepmc.org/article/MED/36577150

Oxidation of N-Alkyl(iso)quinolinium Salts Over TEMPO@Metal-Organic Framework Heterogeneous Photocatalyst.

Photogenerated holes in the PCN-222's most occupied molecular orbital of visible light irradiation will easily transfer to TEMPO, which will greatly improve the photosynthesis of bioactive quinolones from readily available N-alkylquinolinium salts. TEMPO@PCN-222 exhibited exceptional catalytic stability and substrate tolerance with a yield of 86. 7% for 1-Methyl-2-quinolinone, over four times higher than PCN-222.

Source link: https://europepmc.org/article/MED/36545816

What Makes a Quality Health App? Developing a Global Research-based Health App Quality Assessment Framework for CEN-ISO/TS 82304-2: A Delphi Study.

Background: The absence of an international standard for assessing and reporting health app quality, as well as general confusion about what makes a high-quality health app harmful to such applications' uptake. Methods Two-round Delphi technology with 83 experts from six continents participating in one or both rounds was used to establish consensus on a framework for assessing health app quality. Aims included identifying the top 100 essential questions for uptake of health applications that do or don't qualify as medical devices. From the 52 countries from six continents who served in the SDO technical committees, the participants were invited to comment on 4 working drafts and then vote on the TS. Results The final quality assessment framework includes 81 questions, 67 of which have an effect on the scores of 4 overarching quality aspects. In addition to a detailed review, the scoring system facilitates the reporting of the quality assessment findings in a health app quality score and class. The CEN-ISO/TS 82304-2. 2021 Health software Part 2: Wellbeing and wellness - Part 2: Quality and reliability were approved in May 2021 by 34 national SDOs from six continents, and quality and reliability were assured in May 2021. Conclusions: The results of the study of health app quality assessment were developed in a flexible and usable international standard. The framework will enable manufacturers to improve and efficiently demonstrate the quality of health applications, customers, and healthcare professionals in order to make informed decisions about health apps, consumers, and healthcare professionals in order to make informed decisions on health apps, and insurers can make reimbursement decisions on health apps.

Source link: https://europepmc.org/article/MED/36538379

Factors contributing to the change in thermoneutral maximal oxygen consumption after iso-intensity heat acclimation programmes.

Abstract: With consideration of HA program parameters, biophysical variables, and thermo-physiological responses, we investigated the reasons that could account for the variation in thermoneutral maximal oxygen uptake adaptation to heat acclimation. Partial least squares regression was used to explain variation in the change in V2D9O 2max across the program using 24 variables. With a mean u00b1 SD rise of 2. 9 percent, sixty-three percent of the participants raised Vu02d2max more than the test error. The root mean squared error was minimised, but the most significant difference in Vu02d9O 2max change was explained by a two-component model. Exercise intensities, ambient temperature, HA training days, total exposure time, baseline body mass, whole-body mass loss, and the number of days between the final day of HA and the post-testing day were all contributing to the model: the number of days between the final day of HA and the testing day were all factors that contributed to the model: exercise intensity, ambient temperature, HA training days, HA training days, total exposure time, maximum exposure time, total exposure time, vascular sensation,.

Source link: https://europepmc.org/article/MED/36533403

The importance of tetrel bonding interactions with carbon in two arrestive iso-structural Cd(ii)-Salen coordination complexes: a comprehensive DFT overview in crystal engineering.

In the presence of H 2 L and NaSCN's presence, L = L 1 and L 2 respectively, we'll explore in this essay the serendipitous synthesis of two amazing iso-structural Cd-Salen complexes [L 2 ] in the presence of H 2 L and NaSCN where L = L 1 and 2 respectively. Two distinct Cd metal ions in the inner and outer N 2 O 2 O 2 and inner O 4 compartments are practically filled by two distinct Cd metal ions resulting from the deprotonated form of the ligand, with the Cd metal ions adopting a capped octahedral geometry. Hirshfeld Surface and 2D fingerprint plot analysis reveal that the solid-state crystal structure contains several non-covalent supramolecular interactions delineated by Hirshfeld Surface and 2D fingerprint plot analysis. In a new dimension of DFT, the sparse tetrel bonding interactions in the complicated, involving the CH 3 group, were investigated in a new dimension of DFT.

Source link: https://europepmc.org/article/MED/36545098

Clinical-chatbot AHP evaluation based on "quality in use" of ISO/IEC 25010.

Background In first-level interviews with customers who want to know more about services or products, even in-depth, conversational agents are now a viable alternative to humans. It's difficult to decide how to determine chatbot quality. When the "quality in use" of a software device needs to be determined, the international standard ISO/IEC 25010 recommends a set of key features that should be considered. This article describes how quality should be used to compare clinical chatbot comparison methods. The research suggests a qualitative method that would be based on quality. Conclusions The proposed strategy, according to the study, provides an excellent reference base for performing quality comparisons of medical chatbots compliant with the ISO/IEC 25010 standard.

Source link: https://europepmc.org/article/MED/36525800

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