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Ischemic Stroke - U.S. Department of Veterans Affairs

Summarized by Plex Scholar
Last Updated: 11 May 2022

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Stringent public health measures during COVID-19 across ischemic stroke care systems: the potential impact of patient perceptions on health care-seeking behaviors.

During two separate COVID-19 waves, researchers in Hungary continued to investigate the connections between government health care policies in Hungary, which were introduced with acute ischemic stroke admissions and interventions. We wanted to perform a similar review of changes in ischemic stroke care at two separate medical centers in the United States. Two separate organizations and models of ischemic stroke care were evaluated by a regional comprehensive stroke center telestroke center and a Veterans Affairs inpatient stroke and neurorehabilitation services. However, the VA's experience shows that particular patient populations may respond differently to public health mandates. These findings reveal that changes in stroke incidence during the COVID-19 pandemic may vary regionally and by patient population, as well as by the severity of public health restrictions put into place.

Source link: https://doi.org/10.1007/s11357-022-00566-8


Genetic deletion of endothelial microRNA-15a/16-1 promotes cerebral angiogenesis and neurological recovery in ischemic stroke through Src signaling pathway.

Since boosting protein levels of VEGFA, FGF2, and their respective receptors VEGFR2 and FGFR1, we recently reported that endothelium-specific conditional knockout of the miR-15a/16-1 cluster promotes post-stroke angiogenesis and improves long-term neurological function, as well as long-term neurological recovery. Following MCAO, EC-miR-15a/16-1 cKO mice with MCAO exacerbated spatial impairments and brain atrophy in EC-miR-15a/16-1 cKO mice. In the penumbra of stroked cKO mice, the AZD0530 stifled long-term blood flow and stopped the formation of new microvessels, including functional vessels with blood circulation. Also, AZD0530 blocked the Src signaling pathway by downregulating phospho-Src and its downstream mediators in post-ischemic brains.

Source link: https://doi.org/10.1177/0271678X211010351

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions