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"Adenosine deaminase 2 deficiency is a disease that results in chronic inflammation of various organs. Even among impacted individuals in the same family, the severity of the illness also varies. Inflammation is a common immune system response to injury and foreign invaders. Fevers that are intermittent, meaning they come and go; areas of net-like, mottled skin discoloration; an enlarged liver and spleen; and recurrent strokes that affect brain structures that can start in the first few years of life are among the signs and symptoms that can be related to ADA2 deficiency. In some people, ADA2 deficiency leads to additional immune system abnormalities that can raise the risk of bacterial and viral infections. Deficiency deficiencies in ADA2 are often described as a symptom of polyarteritis nodosa, a condition that causes inflammation of blood vessels throughout the body. However, not all researchers agree that ADA2 deficiency is a form of PAN.
"COL4A1-related brain small-vessel disease" is one of a group of conditions related to COL4A1 -related disorders. People with the COL4A1-related brain small vessel disease have leukoencephalopathy, which is a change in a form of brain tissue that can be seen by magnetic resonance imaging. People affected by auras may also experience seizures and migraine headaches as a result of graphical sensations. People with COL4A1-related brain small-vessel disease have cloudy eye glass and the presence of arteries that twist and turn abnormally within the eye's light-sensitive tissue at the back of the eye. Following any minor injury to the eye that may have caused bleeding within the eye, which can lead to temporary vision loss. Some people with COL4A1-related brain small-vessel disease have no signs or symptoms of the disease. ".
"A migraine is a form of headache that most often results in intense, throbbing pain in one area of the head. " Migrant migraines can go from a year to multiple times a week. A person is considered to have persistent migraines if they experience 15 or more headache days a month, with eight of those days involving migraine headaches. A migraine typically has three phases: the period leading up to the headache, the migraine itself, and the period immediately following the headache. Many hours up to several days before the headache appears, you may have started the premonitory phase. An aura is a temporary series of neurological signs associated with migraine for one-third of people with migraines. An aura usually appears within one hour of the onset of a migraine. The pain can range from a few hours to a few days in the headache phase. People who have suffered may also have brief episodes of head pain when moving their head. This is a rare occurrence, but people with migraine, especially women with migraine with aura, are at an elevated risk of a stroke triggered by a lack of blood circulation to the brain. There are several migraine disorders that typically have additional signs and symptoms. For example, familial hemiplegic migraine and sporadic hemiplegic migraine are two types of migraine that are characterized by migraine with a temporary disability that affects one side of the body. '.
Source link: https://medlineplus.gov/genetics/condition/migraine
"Hypertension is abnormally high blood pressure in the arteries, which are the blood vessels that carry blood from the heart to the rest of the body. " Blood pressure is the product of the blood pushing against the artery walls, and it is measured in millimeters of mercury. The top number in a blood pressure survey is the pressure when the heart pumps, and the bottom number is the pressure between heart beats. Hypertension has no signs, and many affected individuals are unaware of their condition. To pump blood through the body, the heart and arteries must work harder than normal when blood pressure rises. Heart disease is a result of heart disease linked to extra work and a lack of oxygen. In addition, artery blockage in the heart, causing a heart attack, or to the brain, can cause a type of stroke called an ischemic stroke. When a damaged blood vessel in the brain bursts, another form of stroke, termed a hemorrhagic stroke, can occur. Vision loss can be caused by a lack of blood flow in the arteries of the eyes.
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