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Ischemic Stroke - Europe PMC

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Last Updated: 11 June 2022

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Concomitant Sympathetic and Parasympathetic Dysfunction after Acute Ischemic Stroke.

"Purpose Autonomic dysfunction is underrecognized complication of acute ischemic stroke" says the author. The cortical control of sympathetic activation has mainly lateralized to the right hemisphere and parasympathetic stimulation to the left hemisphere. Case report We present the case of a 73-year-old woman with acute ischemic stroke in the left middle cerebral artery territory of the left middle cerebral artery territory, whose neurological signs improved immediately after thrombolysis and endovascular thrombectomy. Conclusions of the case "In the left hemisphere, the case provided more insight into the phenomenon and recovery course of concurrent sympathetic and parasympathetic dysfunction linked to ischemic lesions. ".

Source link: https://europepmc.org/article/MED/35470411


Antiplatelets and Anticoagulants in Ischemic Stroke,Transient Ischaemic Attack: A Practice Survey Among Singapore Neurologists.

"Purpose Evidence-based stroke clinical practice guidelines provide insight into how to properly treat patients with cerebrovascular disease. " This study was undertaken to determine how adult neurologists in Singapore would use antiplatelets and anticoagulants for their ischemic stroke patients in various settings where the evidence is uncertain. 5. 5% aspirin plus dipyridamole, 71% preferred aspirin only, 71% long-term secondary prevention, 71% preferred aspirin only, 22. 6% clopidogrel/ticlopidine only, 66% clopidogrel/ticlopidine only, 75% aspirin plus dipyridamole. If patients on the preferred AP receiving another cerebrovascular disease with no apparent underlying cause, 48. 4% could change the AP, and 25. 8% would add another AP. If you're looking for a unique AC for non-cardioembolism, 54. 8% will have anti-platelet therapy, and 19. 4% will increase AC. Conclusions The widespread use of aspirin for long-term secondary prevention in Asia is similar to other countries. The lack of adequate evidence to guide therapy in the various specific stroke patient management scenarios may have caused variation in the use of antithrombotic drugs in other settings.

Source link: https://europepmc.org/article/MED/35470408


Urgent Demand of Network Access for Acute Ischemic Stroke Management in Taiwan.

"Time is the determining factor in the success of acute ischemic stroke reperfusion therapy. " Therefore, it is vital for stroke center accreditation standards and capabilities to ensure prompt and appropriate care for the eligible stroke patients. All levels of stroke center network must be operating effectively in order to achieve optimal acute ischemic stroke therapy. Taiwan will rewrite stroke center accreditation and establish the most effective acute stroke care network as soon as possible in the future.

Source link: https://europepmc.org/article/MED/35437741


Stellate ganglion block reduces inflammation and improves neurological function in diabetic rats during ischemic stroke.

"Both diabetes mellitus and stroke are attributed to systemic inflammation that has exacerbated patient outcomes. " Therefore, it is hypothesized that stellate ganglion block may be a potential therapy for diabetic patients. Our findings revealed that stellate ganglion block did not raise the blood glucose level in diabetic rats with diabetes mellitus, but it did decrease the cerebral infarct volume and cerebral water content. However, injection of Toll like receptor 4 agonist lipopolysaccharide 5 minutes before the stellate ganglion block prevented the formation of a stellate ganglion block, whereas injection of TAK242 had no such effect. We also discovered that stellate ganglion block, which was performed at night, had no effect on diabetic ischemic stroke. We also found that circadian rhythm affected the therapeutic results of stellate ganglion block therapy.

Source link: https://europepmc.org/article/MED/35142688


Effects of electroacupuncture on the functionality of NG2-expressing cells in perilesional brain tissue of mice following ischemic stroke.

"Our report looked at the effects of electroacupuncture therapy at the Sishencong acupoint on motor function after ischemic injury in the brain by investigating the rehabilitative properties of NG2-derived cells in a mouse model of ischemic stroke. " With edaravone, a free radical scavenger, and 1 mA EA stimulation was more equivocative than 3 mA EA stimulation or positive control therapy. With 1 mA EA stimulation, the characteristics of NG2-expressing cells were boosted, improving their survival in perinesional brain tissue by decreasing tumor necrosis factor alpha levels. Neurotrophic factor/tropomyosin receptor kinase B and glycogen synthase 3 beta stimulation were both greatly stimulated by brain-derived neurotrophic factor/tropomyosin receptor kinase B and glycogen synthase 3 beta signaling, as well as glycogen synthase kinase 3 beta signals. The results show that EA therapy may prevent functional loss at the perilous site by raising survival and differentiation of NG2-expressing cells by the introduction of brain-derived neurotrophic factor-induced signaling, which is then ameliorating motor dysfunction. ".

Source link: https://europepmc.org/article/MED/34916441


Optogenetics stimulates nerve reorganization in the contralesional anterolateral primary motor cortex in a mouse model of ischemic stroke.

"Rent anterolateral motor cortex is a vital motor auxiliary area, and its function is similar to that of the human premotor cortex. " Motor behavior has been shown by activation and inhibition of the contralesional anterolateral motor cortex. Moreover, RNA-seq results showed that multiple biological reactions regulated by the cALM were upregulated immediately after optogenetic cALM inhibition, and that several immediate-early genes were expressed at higher levels after optogenetic inhibition than after optogenetic activation. The c-FOS signal in layer V of the primary motor cortex in the ischemic hemisphere's ischemic hemisphere's ischemic hemisphere's ischemic hemisphere's primary motor cortex was higher after optogenetic cALM activation than it was after optogenetic cALM inhibition, according to an immunofluorescence analysis. These results, taken together, show that optogenetic cALM stimulation aids neural reorganization in the primary motor cortex of the ischemic hemisphere's primary motor cortex, and that optogenetic cALM inhibition and activation have different effects on neural plasticity. ".

Source link: https://europepmc.org/article/MED/34916439


Cardiac Myxoma as a Rare Cause of an Ischemic Stroke of the Vertebrobasilar Territory in a Young Adult: A Case Report

"Myxomas are the most common primitive cardiac tumors. " Myxomas are mainly related to cardiovascular events, whether caused by a migrating piece of the tumor or by an attached clot that was detached from the tumor, according to this review. The presence of a cardiac mass was revealed during a Cardiac survey.

Source link: https://europepmc.org/article/MED/PMC9170454


Longitudinal Study Reveals Long-Term Proinflammatory Proteomic Signature After Ischemic Stroke Across Subtypes.

"Background Inflammation plays both a role in stroke pathogenesis and brain injury responses. " In a longitudinal ischemic stroke study, we sought to find proteins that reflected acute-phase response and proteins that were more likely to represent proinflammatory responses present before stroke by broadly profiling inflammation-related plasma proteins. Participants were from a Swedish ischemic stroke cohort, according to the Methods. In multivariable binary regression models adjusted for age, sex, cardiovascular risk factors, and multiple testing, correlations between proteins and ischemic stroke or subtype were investigated. Ischemic stroke was associated with a 3-month follow-up, 51 proteins, and a 7-year follow-up 50 proteins. Generally speaking, large artery and cardioembolic stroke had the highest protein levels. Conclusions We discovered inflammation-related proteins that were differentially affected in ischemic stroke cases compared to controls only in the acute phase and some that remained elevated at later time points. ".

Source link: https://europepmc.org/article/MED/35686557


Thrombolysis for Acute Ischemic Stroke in Patients With Premorbid Disability: A Meta-Analysis.

Patients with acute ischemic stroke have been excluded or poorly represented, and the benefit of alteplase in this population remains uncertain. Patients with disabilities treated with IVT had a greater chance of returning to baseline function than those who did not receive IVT. Although there were numerically more sICHs in the IVT group, mortality and rates of sICH were not significantly different between patients with IVT-treated disability and those not treated. However, mortality was 37% higher in patients with premorbid disability than those with no premorbid disability. Conclusions The use of IVT in patients with disabilities was associated with improved outcomes in comparison to patients who did not receive IVT without statistically significant added risks of sICH or mortality. ".

Source link: https://europepmc.org/article/MED/35686556


2021 Taiwan Stroke Society Guidelines of blood pressure control for ischemic stroke prevention.

"Background Since the release of the 2015 Taiwan Stroke Society Blood Pressure for Treatment and Prevention of Stroke Guideline, several new scientific reports have wondered whether a tighter blood pressure target would be more helpful for stroke prevention. Methods The TSS guideline consensus group makes recommendations on stroke prevention based on updated data. Conclusions The BP target for most stroke patients with hypertension is 130/80 mm Hg.

Source link: https://europepmc.org/article/MED/35507097

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions