Advanced searches left 3/3

Ischemic Stroke - DOAJ

Summarized by Plex Scholar
Last Updated: 11 June 2022

* If you want to update the article please login/register

Serum S100B and NSE Levels Correlate With Infarct Size and Bladder-Bowel Involvement Among Acute Ischemic Stroke Patients

"Objectives Stroke, a common global health problem," Smith says. The use of biochemical markers for stroke diagnosis, severity, and prognosis is on the rise, particularly in rural and regional areas of India, as well as its limitation. In India, only a handful of studies on stroke biomarkers have been published. This research was therefore conducted to see if there were any correlations between serum neuron-specific enolase and S100 calcium-binding protein B levels with stroke risk in acute ischemic stroke patients. According to Infarct number and analysis of variance, the three groups were divided arbitrarily into three groups. Multivariate logistic regression analysis was used to determine the independent predictors of infarct size in stroke cases. The Mannu2013Whitney U test demonstrated an association between serum S100B or NSE levels and clinical characteristics. Conclusions Correlation between serum S100B protein levels and NSE with a higher infarct volume was highly significant. A larger infarct size can be obtained by using multivariate regression analysis, bladder and bowel involvement, stroke prevention, and dyslipidemia among stroke victims. Both NSE and S100B levels were strongly associated with bladder bowel involvement in stroke patients, according to Mann's (2013)Whitney U test. Conclusions: There was a positive correlation between serum S100B and NSE levels with infarct size, which led to a positive correlation. Thus, protein S100B and NSE measurements may be used to determine infarct size and may be predictors of severe clinical manifestations of acute ischemic stroke. ".

Source link: https://doi.org/10.1055/s-0042-1743214


Dyslipidemia among Patients with Ischemic Stroke in the Department of Medicine of a Tertiary Care Centre: A Descriptive Cross-sectional Study

"Introduction: Stroke is a leading cause of morbidity and disability in the Asian population. " The aim of the study, which sought to determine the prevalence of dyslipidemia among patients with ischemic stroke in a tertiary care center's Department of Medicine. Methods: This is a descriptive cross-sectional review of 150 diagnosed cases of ischemic stroke admitted in the Department of Medicine from 1st October, 2020 to first October, 2021. In Microsoft Excel 2010, data were entered into Microsoft Excel 2010 and analysis was performed using the Statistical Package for the Social Sciences version 22. 0. Results: Dyslipidemia among the ischemic stroke patients was 120 percent. In 64 patients, high total cholesterol in 70, elevated low-density lipoprotein cholesterol in 54, and low low-density lipoprotein cholesterol in 51 patients, high total cholesterol was present. Conclusions: The prevalence of dyslipidemia among ischemic stroke patients was higher than those done in similar settings.

Source link: https://doi.org/10.31729/jnma.7491


The efficacy and safety of fingolimod plus standardized treatment versus standardized treatment alone for acute ischemic stroke: A systematic review and meta‐analysis

"Abstract" is the most common form of stroke. Fingolimod, a sphingosine analog that works on sphingosine receptors, is a sphingosine analog that acts on sphingosine u20101u2010phosphate receptors. In proofu2010concept trials, the safety and effectiveness of fingolimod in both patients with intracerebral hemorrhage and patients with AIS have been investigated. At day 90, we compiled five studies; a key meta-u2010analysis forest plot was developed for the percentage of patients whose modified Rankin scale score was 0 u20131; a novel analysis forest plot was conducted. With a mean difference between the efficacy of fingolimod plus standardized therapy and standard treatment alone, a sensitivity analysis was conducted. Regardless of the I2 index, the random effect model is used for meta-u2010analysis. Patients with a MRS score of 0 to u20131 on day 90 between fingolimod plus standardized treatment and standard treatment alone was 2. 59 percent. The Fingolimod plus standard treatment group reduced infarct growth and improved clinical function relative to the more common treatment regimen. ".

Source link: https://doi.org/10.1002/prp2.972


Machine Learning-Based Model for Prediction of Hemorrhage Transformation in Acute Ischemic Stroke After Alteplase

"Hemorrhage clearance is the most feared complication of intravenous thrombolysis in acute ischemic stroke. " In the treatment decision-making for AIS, the anticipation of HT after IVT is crucial. Following IVT, we invented and tested various machine learning algorithms, capable of predicting HT in AIS. In this retrospective review, a total of 345 AIS patients who received intravenous alteplase between January 2016 and June 2021 were included. According to the ROC curve results, the AUCs of HT predicted by the RF model, LR model, MSS, SITS, and SEDAN scales after IVT were 0. 695, 0. 657, 0. 655, and 0. 655, respectively. The RF prediction model was clinically interpretable thanks to the SHapley Additive exPlanation values. After intravenous alteplase, which had the sensitivity of 66. 7 percent but inaccurateness was 87%," this report revealed, an RF machine learning approach was able to predict HT in AIS patients.

Source link: https://doi.org/10.3389/fneur.2022.897903


The antioxidant enzyme Peroxiredoxin-1 controls stroke-associated microglia against acute ischemic stroke

"However, the specifics of microglia responsible for mitigating ROS damage" and molecular markers of heterogenetic microglia in the I/R damaged brain have yet to be clarified. " We've discovered a new form of microglia in the I/R injured brain, which is linked to stroke. After transient middle cerebral artery occlusion surgery to simulate ischemic stroke, transient middle cerebral artery occlusion surgery was used to assess transcriptional changes of microglia and immune cells in the contralateral and ipsilateral hemispheres. We identified a unique species of microglia with improved antioxidant function and markers that are similar to those of disease-associated microglia, so we named them stroke-associated microglia. The SAM population was specifically reduced in Prdx1u2212/u2212 mice, and this mice had decreased ROS damage resistance in those mice, according to scRNA transcriptomics results.

Source link: https://doi.org/10.1016/j.redox.2022.102347


Dental pulp stem cell transplantation facilitates neuronal neuroprotection following cerebral ischemic stroke

"Objectives: This research was designed to identify and evaluate dental pulp stem cell transplantation as a potential ischemic stroke therapy that reduces neuronal death/apoptosis. " DPSCs were isolated from the affected third molars of healthy volunteers and then intracranially injected in Sprague Dawley rats that had been exposed to 2 h of middle cerebral artery occlusion at 24 h post-ischemic stroke, according to their materials and methods.

Source link: https://doi.org/10.1016/j.biopha.2022.113234


Comparisons of Prehospital Delay and Related Factors Between Acute Ischemic Stroke and Acute Myocardial Infarction

"Background Prehospital delay is a contributing factor to poor outcomes in both acute ischemic stroke and acute myocardial infarction. " Methods and Results We identified patients with AIS and AMI who were admitted to the 11 Korean Regional Cardiovascular Centers via the emergency room between July 2016 and December 2018. Delayed arrival was defined as a prehospital delay of more than three hours, and the generalized linear mixedu2010effects scheme was used to investigate the effects of potential predictors on delayed arrival. Prehospital delay in AIS was 6. 05 hours and 3. 00 hours in AMI, according to the median value of prehospital delay. The utilization of emergency medical services was the primary cause of delayed arrival in both groups, according to both groups. There were no or minimal effects on delayed arrival in AIS, but age and female sex were among the most likely causes of delayed arrival in AMI. ".

Source link: https://doi.org/10.1161/JAHA.121.023214


Plasma Total Homocysteine Level Is Related to Unfavorable Outcomes in Ischemic Stroke With Atrial Fibrillation

"Background Despite patients with stroke caused by other mechanisms, the effect of elevated plasma homocysteine on patients with both ischemic stroke and fibrillation is unknown. " This research was intended to determine the relationship between tHcy level and patients with AF-related stroke. Methods and Results We included consecutive patients with AF-related stroke between 2013 and 2015 from the registry of a real world prospective cohort of 11 major centers in South Korea. Since renal function is very affected by tHcy, we conducted a subgroup analysis according to the presence of renal dysfunction. A total of 910 patients with AF-u2010-related stroke were evaluated. AU-related stroke patients with a higher plasma tHcy level were correlated with unfavorable outcomes in patients with AF-related stroke. ".

Source link: https://doi.org/10.1161/JAHA.121.022138


Yield of Echocardiography in Ischemic Stroke and Patients With Transient Ischemic Attack With Established Indications for Long‐Term Direct Oral Anticoagulant Therapy: A Cross‐Sectional Diagnostic Cohort Study

"Background In patients with ischemic stroke and transient ischemic syndrome with established indications for immediate oral anticoagulants prior to the index event, there were attempts to establish the diagnostic yield of transthoracic and transesophageal echocardiography. The study included results and findings This was a retrospective cohort study of consecutive patients with no evidence for long-term therapeutic direct oral anticoagulants, according to a single comprehensive stroke center with ischemic stroke or transient ischemic attack. According to TEE, 16 of 102 patients with 20 management-related pathologies were identified. Other relevant findings were obtained in a further 3 of 191 patients with TTE and 4 of 101 patients with TEE. Both TTE and TEE patients with established guidelines for long-term direct oral anticoagulant therapy and stroke who underwent echocardiography found a relevant and similar number of managementu2010risk pathologies and predictive biomarkers, which may help to direct diagnostic workup in such patients. ".

Source link: https://doi.org/10.1161/JAHA.121.024989


Patients With Acute Ischemic Stroke Who Receive Brain Magnetic Resonance Imaging Demonstrate Favorable In‐Hospital Outcomes

"Background" uses inpatient brain magnetic resonance imaging in patients with acute ischemic stroke is extremely institution dependent, and it has been associated with increased duration and cost of hospital stay. " To justify its funding requirements, we investigated whether inpatient brain MRI in patients with acute ischemic stroke is linked to improved clinical outcomes. Conclusions Inpatient brain MRI in patients with acute ischemic stroke is associated with a significant decrease in the incidence of inpatient mortality and complications, but hospitalization costs are still at an affordable price.

Source link: https://doi.org/10.1161/JAHA.120.016987

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions