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We've taken a patient with acute kidney disease with first kidney biopsy indicating acute interstitial nephritis with a polymorphous infiltrate of plasma cells. She underwent a second kidney biopsy, which revealed plasma cell-rich interstitial infiltrate among a population of IgA lambda-restricted plasma cells on routine immunofluorescence. Hevylite HLC antibody was used to reassess the first biopsy, which revealed the presence of a population of plasma cells with IgA lambda restriction.
Source link: https://doi.org/10.1016/j.xkme.2022.100514
Urinary tract tuberculosis is a common symptom of extrapulmonary tuberculosis that can infrequently present as renal carcinoma, resulting in serious blunders in the diagnosis and treatment of UTTB. Case study The main symptom of a 76-year-old Syrian man was diagnosed with gross hematuria. The suspicion of a speared renal mass in the right urinary tract was raised by a urinary endoscopic examination and pelvic multi-slice computed tomography imaging. The histopathology of the resected mass revealed the diagnosis of UTTB and interstitial nephritis after nephrectomy and ureterctomy.
Source link: https://doi.org/10.1186/s13256-022-03491-8
In a region of Morocco, the aim of this retrospective study was to determine the clinical features, causes, and outcomes of patients with GIN in adult patients. All native renal biopsy procedures were evaluated, but only cases of GIN were investigated. The mean serum creatinine level at the renal biopsy was 39. 1 mg/L, according to u00b1 20. 7 mg/L. Patients with drug-induced GIN and sarcoidosis had a positive renal result, according to a report. To obtain epidemiology and treatment of rare kidney diseases, one of the key findings from our research and the earlier studies is that improved data collection methods such as biopsy registries are required.
Source link: https://doi.org/10.4103/1319-2442.289445
Case study A 57-year-old Caucasian woman with treatment-resistant chronic schizophrenia died after starting drug therapy with clozapine following acute renal failure. The patient's renal function returned to normal after clozapine was removed, but no other changes to medication had been made. The patient had been exposed to clozapine about four years ago, but she had a similar reaction four years ago. Renal reactions to clozapine are extremely rare, but if not identified promptly, it could be fatal.
Source link: https://doi.org/10.1186/1752-1947-0003-0000008574
Interstitial nephritis with proteinuria > 1 g/day is unusual, but it is almost always the result of drug-induced ATIN with an associated minimal change glomerulonephritis. Here, we review a series of five rare cases of interstitial nephritis without GN but with proteinuria > 1 g/day, which were traced from renal biopsies done from February 2008 to March 2009. Only five patients from a total of 236 patients who underwent renal biopsy met the inclusion criteria. Hematuria in two patients, pyuria in three, and nephrotic range proteinuria in two patients were found in Urinalysis. Granulomatous interstitial nephritis in three patients and small vessel vasculitis in two of them were discovered by light microscopy of renal biopsies. Along with vaping, one patient had nongranulomatous interstitial nephritis. The only result in one patient was acute interstitial nephritis. In conclusion, patients with interstitial nephritis can exhibit moderate to moderate proteinuria, owing to a cytokine-like permeability increasing factor secreted by inflammatory cells in the interstitium.
Source link: https://doi.org/10.4103/1319-2442.93190
Abstract Background An acute interstitial nephritis is a common cause of kidney disease, accounting for up to 27% of unexplained renal impairment. Following two new paediatric reports of suspected mesalazine-induced AIN within our own department, we carried out a comprehensive review of the literature to answer the following question: Is interstitial nephritis associated with 5-aminosalicylate therapy? We wanted to find the number of cases reported in the literature of biopsy-proven 5-ASA induced interstitial nephritis in children and adults with IBD. In those with IBD, studies were included if they announced an outcome of AIN, confirmed on biopsy, and it was thought to be secondary to a 5-ASA drug in those with IBD. The median rise in creatinine was 3. 3 times greater than the baseline comparison. The current federal government's annual monitoring of renal function may not be able to identify cases early enough.
Source link: https://doi.org/10.1186/s40001-022-00687-y
Proteinuria, renal insufficiency secondary to focal segmental glomerulosclerosis, and thrombotic microangiopathy are among the many adverse effects related to sunitinib. A potential class effect can be seen in four other cases of AIN, as well as a decrease of the vascular endothelial growth factor by either TKI or antibodies. Given our experience, we recommend monitoring renal function with VEGF inhibition, and in the case of renal dysfunction in the context of uncertain diagnosis, we recommend prompt biopsy.
Source link: https://doi.org/10.1155/2017/6328204
Acute interstitial nephritis is a common cause of acute kidney injury, but its connection with cocaine use is extremely unusual. We chronicle the case of a patient who suffered acute interstitial nephritis as a result of cocaine insuffulation in this series. This paper illustrates that acute interstitial nephritis may be added to the list of patient characteristics with acute kidney injury and a history of cocaine use. The therapeutic approach for cocaine-related kidney disease may differ from other etiologies responsible for acute renal insult.
Source link: https://doi.org/10.1177/2324709620932450
Tubular cell damage and inflammatory lesions of kidneys are characteristic of tubular-interstitial nephritis. Baicalein is a flavonoid compound discovered in the roots of Scutellaria baicalensis Georgi's Baicalensis Georgi's Scutellaria baicalensis Georgi. A lipopolysaccharide-induced TIN cell model was used in this research to investigate the anti-inflammatory and anti-oxidative effects of BAI on TIN patients and a lipopolysaccharide-induced TIN cell model. Using enzyme-linked immunosorbent assay, the expression of interleukin-6, IL-10, and tumor necrosis factor u03b1 in serum samples of TIN patients and culture supernatants of renal proximal tubular epithelial cells was determined. Using MTT assay and Guava Nexin assay, respectively, productivity and apoptosis of RPTECs were determined. In vivo and in vitro, BAI reduced inflammation and oxidative stress. In RPTECs, Phorbol ester, a trigger of NF-u03baB, attenuated the effects of BAI on LPS-induced inflammatory cytokine expressions. BAI had anti-inflammatory and anti-oxidative effects on TIN patients and LPS-induced RPTECs by down-regulating NF-u03baB and MAPK pathways, according to the author.
Source link: https://doi.org/10.1590/1414-431x20187476
Interstitial nephritis can develop in patients with human immunodeficiency virus infection, but not as a result of HIV infection. Patients with HIV-associated nephropathy may have interstitial lesions. However, interstitial nephritis without the glomerular injuries characteristic of HIVAN and without the risk factors discussed earlier are extremely uncommon. We review a rare case of interstitial nephritis that was likely triggered specifically by HIV infection and not by other etiologies.
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