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Abstract While deposition of immune complexes in the glomeruli is suspected of starting lupus nephritis, the severity of tubular injury in the glomeruli is better predicted of end stage kidney disease than the glomerular injury. However, the mechanisms underlying tubular injury in lupus nephritis are only partially understood. Iron deposits in tubular epithelial cells of lupus nephritis patients and mice. Here we describe intra-renal ferroptosis as a novel pathological feature in human and murine lupus nephritis of various etiologies. Increasing lipid perspiration in the tubular segments of Kidneys of lupus nephritis patients and mice, mainly in the tubular segments. The preferred lipid substrate for lipid peroxidation and ferroptosis was revealed to be elevated esterification of murine nephritic kidneys' sn-2 chain of phosphatidylethanolamine with adrenic acid, according to the preferred lipid substrate for lipid peroxidation and ferroptosis, with adrenic acid.
Source link: https://doi.org/10.21203/rs.3.rs-2038767/v1
Context: u2014 Light chain proximal tubulopathy is a product of acute tubulointerstitial nephritis, which is a variant of light chain proximal tubulopathy nephritis. In LC-ATIN, a 2014 study sought to determine the clinical pathologic characteristics of patients with LC-ATIN and investigate the proximal tubular injury and mechanism of interstitial inflammation. U2014 Design: u2014 Based on the archives of 543 renal biopsy specimens, a total of 38 cases of LC-ATIN was identified. U2014 A characteristic finding in LC-ATIN cases was immunofluorescence staining of monoclonal light chains along tubular basement membranes in a linear manner and inside proximal tubular cells with a granular pattern. m. u2014 The four tubular injury markers were all positive in ten of 15 LC-ATIN cases. Dendritic cells were identified within the tubulointerstitium in the renal biopsy samples, interfusing with surrounding tubules with light-chain deposits and inflammatory cells. U2014 The onset of a severe proximal tubular injury is related to LC-ATIN, and monoclonal light chains embedded in proximal tubular cells contribute to the injury.
Source link: https://doi.org/10.5858/arpa.2018-0032-oa
Uveitis went into remission after treatment, with BCVA 20/20 in both eyes and CNV lesions inactive. Although anterior uveitis is more prevalent in TINU, posterior uveitis with inflammation of the optic nerve should be properly investigated to rule out juxtapapillary CNV, both at the time of active uveitis and in follow-up, since TINU's active uveitis can be complicated by CNV even at the later stages of the disease process.
Source link: https://doi.org/10.3390/medicina58091260
ABSTRACT Background We know that pulsed methylprednisolone can be used to improve kidney function in patients with sarcoidosis tubulointerstitial nephritis. Patients were randomly selected to receive a methylprednisolone pulse for three days, followed by oral prednisone or oral prednisone 1 mg/kg/day alone. The mean eGFR at 3 months in the intention-to-treat population did not differ significantly between the PRD and MP groups: 45 and 46 mL/min/1. 73 million2. In 16 of 20 PRD patients and 10 of 20 MP patients, the primary end point was reached at 3 months. For both groups, eGFR at 1 month was highly correlated with eGFR at 12 months. Conclusions Compared to a conventional oral steroids regimen, intravenous MPs may have no additional benefit for renal function in patients with tubulointerstitial nephritis caused by sarcoidosis.
Source link: https://doi.org/10.1093/ndt/gfac227
Background: Tubulointerstitial nephritis and uveitis syndrome is a rare disorder that is characterized by sudden-onset non-granulomatous anterior uveitis associated with tubulointerstitial nephritis. Patients in the majority of cases had ocular disease concurrently with renal disease. Patients were diagnosed with bilateral or unilateral alternating posterior uveitis in three instances, and in four cases, they presented with bilateral panuveitis. In one instance, the uveitis was anterior in the right eye and posterior in the left eye, and in two others, there were two instances of bilateral alternating anterior uveitis. In almost all patients, acute kidney injury reverted completely, and no one progressed to chronic kidney disease. Patients with TINU may often suffer with atypical uveitis. Even if not bilateral anterior, we suggest that patients with sudden-onset uveitis be referred to a nephologist for an investigation of the potential presence of renal disease.
Source link: https://doi.org/10.3390/jcm11174995
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