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A substance use disorder is characterized, in part, by a lack of supervision over opioid use and administration. In clinical and preclinical studies of SUD, the prefrontal cortex is highly involved in behavior control, as well as deficiencies in PFC structure and function. Despite widespread use among adolescents and children, inhalants are among the least studied of the various classes of drugs involved with the development of SUD. We then discuss how inhalants, including toluene, influence various behaviors, with an emphasis on those associated with PFC function and how chronic use of inhalants changes brain function and neuronal signaling.
Source link: https://doi.org/10.1016/j.addicn.2022.100059
Changes in cognitive function and damage to brain structures are common in adolescents with substance use disorder, according to the study. The difference between inhalant-consuming adolescents and a control group in this report was determined by graph theoretic analysis to determine network efficiency in the resting state for three networksu2014default mode network, salience network, and fronto-parietal network. The relationship between inhalant abuse and inhibitory control and sequential planning was partially mediated by DMN efficiency, according to the mediation studies.
Source link: https://doi.org/10.3389/fpsyt.2020.00209
Depending on the local climate and demographic conditions, there are several variations between common inhalant allergens. According to their geographic location, age, and sex, this report sought to compare common inhalant allergens between Koreans and non-Koreans. Methods: This research evaluated 15,334 people who underwent serum tests for multiple allergen-specific immunoglobulin E at a tertiary academic medical center between January 2010 and December 2016. Findings: The house dust mite was the most common allergen in both Koreans and non-Koreans, although the number of people with HDM sensitization was greater among Koreans. In the Gangwon area, high sensitization rates for various pollen types were reported, among Koreans, whereas Japanese cedar pollen was unusual among Koreans in Jeju's region. Grass pollen and animal dander were relatively common among Americans, while weed and grass pollen were the 10 most common allergens for people from Central Asia.
Source link: https://doi.org/10.1016/j.alit.2018.07.005
Inhalant abuse reports in India are extremely limited. We investigate the demographic and medical profile of inhalant users at a Drug De-addiction and Treatment Center in north India's northern India's treatment seekers. Methods: 92 cases reporting inhalant use were found among the treatment seekers at the Drug Deposition and Treatment Centre over ten years. For 87 cases, the complete record files were available for 92 of these 92 cases. Inhalant abuse per year rise steadily to a high of 20 cases in 2006 and then stayed at 1-3 percent of new cases annually over a ten-year period. Of the 87 cases, all were males with a mean age of 18. 9 years, mean education of 9. 8 percent, and mean family income of Rs. The most common inhalant was typewriter correction fluid, followed by typewriter diluent fluid and glue. In 26. 4 and 32. 9 percent subjects, respectively, the mean age of inhalant use was 16. 3 yr. and the family history of substance use. Our findings revealed that the inhalant users were mainly urban youth from middle socioeconomic class families. Inhalant abuse's key sources of exposure were common chemicals such as typewriter correction fluids, and the overwhelming majority of the participants started using it out of curiosity. In addition, almost three-fourth of the respondents used some other form of heroin, with nicotine being the most common.
With remimazolam, total intravenous anesthesia is a critical part of health care quality, but there is no published randomized controlled trial focusing on the quality of recovery in patients undergoing total intravenous anesthesia. Methods This parallel-group, single-blind randomized control trial at a tertiary care medical center in South Korea was carried out to determine the difference in the quality of recovery between patients treated remimazolam and those treated with an inhalant anesthetic agent. Decrement of the QoR-40 score on day 1 was the key success measure, relative to the QoR-40 score on the day before surgery. In Group R than in Group D, the decrement of the QoR-40 score was smaller than in Group D. Conclusions Overall intravenous anesthesia treated with remimazolam maintains a greater degree of recovery than anesthesia treated with an inhalant agent in patients undergoing laparoscopic surgery.
Source link: https://doi.org/10.1186/s12871-022-01770-x
Thinners are widely used as organic solvents in industrial and domestic use. We investigated the effects of paint thinner inhalation in adult male mice here. Following repeated enrollment in long-term therapies spanning 12 weeks, depression-like behaviors and an anxiolytic effect were discovered. Following both chronic and subchronic therapies, prolonged, but not acute thinner inhalation greatly reduced adult neurogenesis in the dentate gyrus, greatly affecting adult neurogenesis, but not acute, limiting progenitor cell proliferation in adult neurogenesis. In addition, a down-regulation of BDNF and NMDA receptor subunit expression, as well as a decrease in CREB expression/phosphorylation were found in chronically treated mice's hippocampi. Our results show no structural or molecular changes in the adult hippocampus after prolonged paint thinner inhalation, leading to reduced hippocampal neuroplasticity and strongly supporting its role in inhalant abuse's behavioral abnormalities.
Source link: https://doi.org/10.3389/fnins.2018.00035
The central nervous system in the United States is highly toxic because they contain numerous hydrofluorocarbons that have a psychoactive effect on the central nervous system. We chronicled a 33-year-old man's diaphoretic and near-syncope after inhaling several cans of Surf Onn electronic duster gas cleaner and causing acute cardiac, liver, and kidney injury later that day.
Source link: https://doi.org/10.12890/2022_003556
Abstract Background Nitrite inhalants are peripheral vasodilators, who have been known to raise the risk of HIV infection among men who have sex with men since the outbreak's inception. New HIV diagnoses among MSM in British Columbia increased by 78% from 1999 to 2004, prompting us to investigate the prevalence and correlates of this modifiable HIV risk factor. By 21. 9 percent of men and was strongly associated with having casual partners, with greater numbers of casual partners and anal intercourse with casual partners, and with anal intercourse with casual partners. Usage of Nitrite inhalant was not linked to the non-use of condoms with casual sexual partners per se. As HIV use rises, MSM's use of nitrite inhalants should be a top priority among HIV prevention efforts since use seems to have risen the risk of infection following exposure to HIV.
Source link: https://doi.org/10.1186/1471-2458-7-35
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