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Influenza Vaccine - PLOS

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Last Updated: 11 November 2022

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Dose-sparing effect of two adjuvant formulations with a pandemic influenza A/H7N9 vaccine: A randomized, double-blind, placebo-controlled, phase 1 clinical trial

We investigated the dose-sparing effect and safety of two distinct squalene-based oil-in-water adjuvant emulsion formulations with influenza A/H7N9 antigen. Effective and systemic, solicited, and unsolicited adverse events occurred in the immediate and systemic study, respectively, 7 and 28 days after each study injection, respectively, whereas serious adverse events SAE were monitored up to 194 days post-second dose. In groups receiving adjuvanted vaccines, a rise in antibody geometric mean titers GMT was observed. Vaccinees receiving IB160-adjuvanted tablets had the most prominent response in group 1B, resulting in a HI GMT rise of 4. 7 percent in 45. 2%, according to MN titers u226540 in 80. 8%, which was 85 percent greater than 78 percent. Vaccinees in SE-adjuvanted vaccines delivered the greatest response in group 2A, with a HI GMT increase of 2. 5 hours and a MN titers u226540 in 57%.

Source link: https://doi.org/10.1371/journal.pone.0274943


Influenza vaccination coverage among an urban pediatric asthma population: Implications for population health

Annual influenza vaccination rates for this population are suboptimal, with asthmatic children being at a high risk of complications from influenza. According to influenza vaccination status, the aim of this study was to identify the characteristics of a high-risk population of asthma patients presenting to a city pediatric emergency department. The Michigan Care Improvement Registry's eligible patient PED records were matched with influenza vaccination records for the 2017–u20132018 influenza season. In the PED, 1049 patients with asthma had been given an influenza vaccine, according to the study. Conclusions: The identification of neighborhood Census Tract and demographic groups with suboptimal influenza vaccination may lead to the creation of targeted public health programs to raise vaccination rates among high-risk patients.

Source link: https://doi.org/10.1371/journal.pone.0269415

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions