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Influenza Vaccine - DOAJ

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Last Updated: 11 January 2023

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NK- and T-cell granzyme B and K expression correlates with age, CMV infection and influenza vaccine-induced antibody titres in older adults

We found that the prevalence and MFI of GZB-expressing NK-cells, CD8+, and Vu03b41+ T-cells, as well as GZK-expressing CD8+ T-cells were significantly higher in older vs. younger adults by up to 5-fold. In older adults, there were no significant links between GZB/GZK expression and sex, frailty, or plasma levels of TNF or IL-6, but those who were seropositive for cytomegalovirus had significantly higher rates of GZB+ NK-cells, CD8+, and Vu03b41+ T-cells, and GZK+ T-cells, with sex, frailty, or plasma TNF/Vu v cytomegal cytome, cytomegalo cytomegant cytomegZB+ TNF or plasma TNF or IL-6 TNF or IL-6 cytometho cytomegalo or IL-6 cytomegalot cytomegalo, CD8+ T-cells, VVu­ vuvu ty, CD8+ T-cells and Vugliav/Vuov/Vuuuuty vs, v vu The frequencies of GZB+ NK-cells were positively connected with vaccine antibody responses against A/H3N2 and A/H3N2, while T-cell frequencies of GZK+ NK and CD8+ T-cells were inversely associated with A/H1N1. These results contribute to our knowledge of how granzyme expression in various lymphoid cell-types may change with age, as well as in older adults' vaccine responsiveness.

Source link: https://doi.org/10.3389/fragi.2022.1098200


Knowledge, barriers and uptake of influenza vaccine among non-health college students at Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia

Background: Viral influenza, one of the world's most infectious disease epidemics, is particularly relevant in Saudi Arabia due to its high susceptibility to transmission in hajj and umrah seasons, but in addition, the disease has a higher incidence of complications that could lead to death. The study was designed and methods: The aim was to establish the connection between uptake of influenza vaccines with knowledge as well as finding the barriers that prevent vaccination among Princess Nourah Bint Abdulrahman University non-health students. Results: The rise in the use of the influenza vaccine in the new year was 15. 3% in the current year and 56. 8% in the previous years. In a percentage of 12. 0% for all, the most common encounter barriers identified by the study participants were concerns over the vaccine's safety, reduction of immunity, and the lack of complete security in unvaccinated student.

Source link: https://doi.org/10.4081/jphr.2020.1856


Characterizing intentions to receive the COVID-19 vaccine among the general population in British Columbia based on their future intentions towards the seasonal influenza vaccine

Introduction: This review examined the relationship between the desire to get a seasonal influenza vaccine and the desire to receive a seasonal influenza vaccine, as well as how the intention to get a COVID-19 vaccine has changed during the pandemic. The desire to receive a COVID-19 vaccine increased over the course of the study period, with the most significant increase coinciding with the announcement of new COVID-19 vaccine approvals in November 2020. Conclusion: The intention to get the COVID-19 vaccine was attributed to seasonal influenza vaccination intention, which is a significant factor in terms of COVID-19 booster doses' development and future planning. Following public announcements of forthcoming vaccine approval, we noticed an increase in the desire to get a COVID-19 vaccine, which highlights the importance of continuing monitoring and reporting vaccine uptake, as well as the potential effects of emerging vaccine safety and effectiveness data on vaccine acceptance.

Source link: https://doi.org/10.1016/j.jvacx.2022.100208


T Cell Transcriptional Signatures of Influenza A/H3N2 Antibody Response to High Dose Influenza and Adjuvanted Influenza Vaccine in Older Adults

However, T cell transcriptional activity that is influencing the humoral immune responses to Fluzone and Fluad vaccines in older adults is still unclear. We conducted a research of 234 older adults who were randomly assigned to Fluzone or Fluad vaccine and collected blood samples at baseline and after immunization on Day 28. In order to find T cell signatures that might explain variations in humoral immune responses by vaccine type, we measured the humoral immune responses to influenza A/H3N2 and performed mRNA-seq transcriptional profiling in purified CD4+ T cells. So, the primary aim of our study was to determine the presence of various gene expressions that influence the antibody titer in the two vaccine groups. In summary, we outlined the genes/proteins and pathways that are essential for cell proliferation and function in CD4 + T cells that are associated with variation in influenza vaccine-induced humoral immunity based on vaccine type.

Source link: https://doi.org/10.3390/v14122763


High Influenza Vaccine Effectiveness and Absence of Increased Influenza-like-Illness Epidemic Activity in the 2021–2022 Influenza Season in Catalonia (Spain) Based on Surveillance Data Collected by Sentinel Pharmacies

All community pharmacies were chosen to publish all influenza-like illness cases reported during the 2021–2022 influenza season and collect influenza surveillance and influenza vaccination data. With a negative COVID-19 screening result and a total number of 412 ILI cases, the sentinel pharmacies reported 212 ILI cases with a negative COVID-19 test and a total number of 412 ILI cases. In the 2021-2022 influenza season, the number of ILI cases reported per week was significantly lower than the MEM-based epidemic threshold, with a significant decline in the MEM-based epidemic. Mean number of ILI cases reported per week in the 2021-2022 influenza season was much lower than during the ILI/influenza epidemic periods that were reported from 2017 to 2020 using the same methodology. Flu surveillance data was not provided by traditional influenza surveillance methods, according to sentinel pharmacies.

Source link: https://doi.org/10.3390/vaccines10122140


Parental Seasonal Influenza Vaccine Hesitancy and Associated Factors in Shanghai, China, during the COVID-19 Pandemic: A Cross-Sectional Study

Background: Seasonal influenza may have overlap with the COVID-19 pandemic, and infants are one of the top target groups for influenza vaccination in China, yet vaccination coverage has been poor. This research was intended to determine the prevalence of parental influenza vaccine hesitancy in infants and children, as well as the associated causes. Conclusions: Public health education in China aimed at improving vaccination-related attitudes and beliefs, as well as knowledge and socioeconomic factors, may help reduce influenza vaccination hesitancy.

Source link: https://doi.org/10.3390/vaccines10122109


Factors of influenza vaccine inoculation and non-inoculation behavior of community-dwelling residents in Japan: Suggestions for vaccine policy and public health ethics after COVID-19

We used the secondary results from the influenza vaccine inoculation behavior survey for community-dwelling adults conducted in 2011, ahead of the COVID-19 pandemic, but after the 2009 novel influenza A pdm 09 pandemic. Many pregnant women had a significantly higher odds of inoculation risk; this was self-evident in that those people were concerned about infection to their family. Many people aged 20–20134 years with a significantly higher adjusted odds ratio of inoculation were those with u201cat least five people with whom they interacted in the neighborhoodu201d.

Source link: https://doi.org/10.1016/j.jvacx.2022.100245


DYNAMIC cohort study evaluating metabolic predictors of influenza vaccine immune response in older adults

We wanted to investigate the causes/predictors of influenza vaccine immune responses in an older adult cohort in Singapore, where influenza is ubiquitous year round. As assessed by seroconversion and D28/D0 log2 HAI fold changes, the primary result of the DYNAMIC prospective cohort study was haemagglutination-inhibition titer reaction to each of the trivalent inactivated influenza vaccine strains at day 28 compared to baseline. Total Vitamin D levels in baseline blood samples were tested for total Vitamin D levels. Influenza A/HK/H3N2 was found with lower HAI fold increase when compared to previous influenza vaccination and higher baseline HAI titers. In a dose-response context, physical fitness has been correlated with a rise in HAI folds for influenza A/HK/H3N2 in a dose-response relationship. Older adults with well-controlled metabolic co-morbidities maintain HAI response to the influenza vaccine, and physical fitness has a positive effect on immune response, particularly influenza A/HK/H3N2.

Source link: https://doi.org/10.1038/s41541-022-00548-z


RIG-I and TLR-7/8 agonists as combination adjuvant shapes unique antibody and cellular vaccine responses to seasonal influenza vaccine

Influenza vaccine performance could be enhanced by a combination of an adjuvant with the ability to raise the host-vaccine response both quantitatively and qualitatively. As determined by IFN-b3 and IL-4 enzyme-linked immunosorbent spot assays, 4-weeks post-prime and post-boost vaccination in BALB/c mice, increased HA-specific serum titers, serum hemagglutination inhibition titers, and splenic T cell responses. A more balanced IgG1/IgG2a response in animals treated with QIV+IMDQ-PEG-Chol did result in a more balanced IgG1/IgG2a vaccination among animals treated with the drug adjuvant during prime vaccination, but increased only IgG2a titers in animals that received the combination adjuvant during prime vaccination, suggesting that class switching events in germinal centers during prime vaccination may have contributed to the success of booster vaccinations.

Source link: https://doi.org/10.3389/fimmu.2022.974016


Can a Two-Dose Influenza Vaccine Regimen Better Protect Older Adults? An Agent-Based Modeling Study

Older adults are at a high risk of influenza morbidity and mortality. This report investigated the effects of a hypothetical two-dose influenza vaccine regimen per season on symptomatic flu cases by lowering symptomatic flu cases by providing pre-season and mid-season cover to offset declining vaccine efficiency. To compare typical one-dose vaccination results to a two-dose vaccination program, the Framework for Reconstructing Epidemiological Dynamics, an agent-based modeling tool, was used to compare typical one-dose vaccination to a two-dose vaccination program. Reductions in cases and hospitalizations resulted, but decreased when 30% of individuals failed to get a second dose, second dose VE was reduced, or overall waning rate to 7% per month. According to agent-based studies, two influenza vaccine doses may reduce infections and hospitalizations in older adults. Despite model scenarios of reduced uptake of the second dose, reduced VE of the second dose, or overall VE waning, the two-dose regimen maintained.

Source link: https://doi.org/10.3390/vaccines10111799

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions