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Inflammatory Bowel Disease - OSTI GOV

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Last Updated: 08 June 2022

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Using Corticosteroids to Reshape the Gut Microbiome: Implications for Inflammatory Bowel Diseases

"Reshaping intestinal microbiota by pharmacologic means may be a viable treatment option. " Here we attempted to delineate the functional characteristics of glucocorticoid-mediated gut microbiota and their subsequent consequences on host mucin regulation and colonic inflammation. Mucin gene expression research was conducted in Intuit mucosa. To determine their functional capacities in recipient hosts, GF mice were standardized with gut microbes from both treated and non-treated groups. Resultsu2014Exposure to DEX in WT mice resulted in significant shifts in gut microbiota over a four-week period. During therapy, there was also a significant down-regulation of colonic Muc2 gene expression. We conclude that commensal gut bacteria may be a key mediator of the inflammatory reactions seen in the large intestine following GC exposure. These findings support the belief that intestinal microbes are a u201cmicrobial organu201d essential for host physiology that can be targeted by medical approaches to restore intestinal homeostasis. ".

Source link: https://www.osti.gov/biblio/1280876

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions