Advanced searches left 3/3

Inflammatory Bowel Disease - DOAJ

Summarized by Plex Scholar
Last Updated: 08 August 2022

* If you want to update the article please login/register

Characteristics of colorectal cancer and use of colonoscopy before colorectal cancer diagnosis among individuals with inflammatory bowel disease: A population-based study.

Introduction There are no recent studies on the occurrence of inflammatory bowel disease-associated colorectal cancer and the use of colonoscopy prior to CRC diagnosis in people with IBD. We reviewed IBD-CRC characteristics, survivorship after IBD-CRC diagnosis, and the use of colonoscopy prior to IBD-CRC diagnosis. Methods We found people with and without IBD from the University of Manitoba's IBD Epidemiology Database and CRC from linkage to the Manitoba Cancer Registry. After CRC diagnosis using Cox regression analysis, we compared the characteristics of IBD-CRC and sporadic-CRC. IBD was associated with an elevated risk of death following CRC diagnosis in 2004-2011, but not in 2012-2017. Pre-IBD-CRC exposure was not associated with improved post-CRC survival. Conclusion The risk of death following CRC diagnosis is not affected by an IBD diagnosis in recent years.

Source link: https://doi.org/10.1371/journal.pone.0272158


Characteristics of colorectal cancer and use of colonoscopy before colorectal cancer diagnosis among individuals with inflammatory bowel disease: A population-based study

Introduction There are no new data on the characteristics of inflammatory bowel disease-associated colorectal cancer and the use of colonoscopy prior to CRC diagnosis among people with IBD. We investigated IBD-CRC characteristics, longevity after IBD-CRC diagnosis, and the use of colonoscopy prior to IBD-CRC diagnosis as time progressed. Methods We found individuals with and without IBD from the University of Manitoba's IBD Epidemiology Database and CRC, as well as the Manitoba Cancer Registry. Using logistic regression and survival after CRC diagnosis using Cox regression analysis, we compared the characteristics of IBD-CRC and sporadic-CRC. After CRC diagnosis in 2004-u20132011, an elevated risk of death was identified with an elevated risk of death, but not in 2012u20132017. Pre-IBC-CRC colonoscopy pre-IBD-CRC remained stable throughout the study period. Conclusion The risk of death following CRC diagnosis is not affected by a diagnosis of IBD in recent years.

Source link: https://doaj.org/article/b6afe612617b482f8e082770d04cb649


Serotype-Specific Pneumococcal Status prior to PCV 13 Administration in Children and Adolescents with Inflammatory Bowel Disease

Before administering the 13-valent pneumococcal conjugate vaccine, the goal of this research was to determine the serotype-specific pneumococcal status of children and adolescents with inflammatory bowel disease who were naïve to pneumococcal vaccination before administering the pneumococcal conjugate vaccine. Each patient was given a single dose of PCV 13. naïve to pneumococcal vaccination prior to the administration of PCV-13, high GMCs were found in older children and adolescents with IBD and were naïve to pneumococcal vaccination.

Source link: https://doi.org/10.5604/17331331.1197279


A nationwide analysis on the influence of obesity in inflammatory bowel disease hospitalizations

Background/Aims Proinflammatory cytokines secretly released from adipocytes can influence the development, progression, and treatment of inflammatory bowel disease, as well as poorer clinical outcomes. Methods For 2016-u20132018, we analyzed results from the Nationwide Inpatient Sample to identify adult hospitalizations with a primary discharge diagnosis of IBD. Patients with obesity hospitalizations with obesity had a greater mean age, middle age predominance, female predominance, and a greater percentage of patients with comorbidities compared to the non-obese cohort. Inpatient mortality was not found between the two groups; however, IBD hospitalizations with obesity had higher mean total hospital charge, longer duration of stay, and a higher risk of complications relative to the non-obese cohorts. Conclusions Obese IBD hospitalizations had increased length of stay, total hospital charge, and complications than the non-obese cohort.

Source link: https://doi.org/10.5217/ir.2021.00046


Evaluation of nutritional status using bioelectrical impedance analysis in patients with inflammatory bowel disease

Because of this, this review explored whether bioelectric impedance analysis could be used to determine patients with IBD's nutritional status. Methods We retrospectively reviewed reports from 139 Korean patients with IBD who were hospitalized between November 2018 and November 2019, using the following criteria. The study included 47 patients with ulcerative colitis and 92 patients with Crohn's disease. Moreover, the group with inactive disease had higher BIA values for body moisture, muscle mass, skeletal muscle mass, body mass index, and mineral content. Conclusions are nutritional markers tested using BIA were correlated with serum nutritional measurements and were inversely linked to disease risk in diabetic mice. Hence, we propose that BIA can be a useful device that can help existing nutritional assessments monitor IBD patients's nutritional status.

Source link: https://doi.org/10.5217/ir.2021.00022


Landscape of inflammatory bowel disease in Singapore

However, the significant rise in the prevalence of IBD in Asia, including Singapore, has drew much attention, and, more importantly, effective and safe monitoring of these groups of patients in terms of therapy, healthcare economics, and patient well-being.

Source link: https://doi.org/10.5217/ir.2021.00089


Biological Activities Underlying the Therapeutic Effect of Quercetin on Inflammatory Bowel Disease

Inflammatory bowel disease is a chronic autoimmune disease that results from unrestrained immune activation and subsequent destruction of colon tissue. Since IBD has few treatment choices for the first time, proper IBD therapies are desperately needed, so better IBD medications are desperately needed. The effect of quercetin on gut microbiome was also highlighted, as well as the potential side effects of the quercetin administration. Also, quercetin could act as a prescription, and the bioavailability of quercetin is enhanced by chemical improvements or the use of innovative drug delivery methods. These lines of evidence point to the possibility of quercetin as a candidate drug for IBD therapy.

Source link: https://doi.org/10.1155/2022/5665778


Host-microbiota interaction-mediated resistance to inflammatory bowel disease in pigs

Abstract Background: Disease resistant phenotypes are connected with immune system function and immune tolerance, and have ramifications for both the livestock industry and human health. Microbiota plays a vital role in regulating immunity and autoimmunity in the host organism, but the effect of host-microbiota interactions on disease resistance phenotypes remains unclear. Here, a multiomics analysis was carried out to determine potential regulatory mechanisms of disease resistance in two pig breeds, as well as the microbiome and host genes. Min pigs showed a high disease resistance despite being exposed to low disease prevalence index and a low histological activity index, compared to Yorkshire pigs under the same feeding and management conditions. In addition, lower amounts of bile acid metabolites and short-chain fatty acids were found in diseased Yorkshire pigs, which were also associated with elevated potentially lethal microbes such as Bilophila and Alistipes. The increase in CD4+ T cells in the lamina propria improved the host immune response in diseased Min pigs, contributing to the maintenance of Th2-type immune function and immune tolerance patterns, as well as the prevention of excessive inflammation with the help of potentially beneficial microbes. Conclusions Cumulatively, the results for the two pig breeds show that host-microbiota crosstalk promotes a disease resistance phenotype in three ways: maintain partial PRR nonactivation, maintaining Th2-type immune strength and immunological tolerance patterns, and rebuilding gut barrier function to shield against colonic diseases.

Source link: https://doi.org/10.1186/s40168-022-01303-1


Appendectomy and risk for inflammatory bowel disease: effect of age and time post appendectomy – a cohort study

Background and objective Appendectomy can reduce the risk of inflammatory bowel disease through an influence on the gut microbiota. paraphrasedoutput:Methods The authors of this research examined the relationships between appendectomy and the prevalence of Crohn's disease or ulcerative colitis in Québec in 1970-1974 and 2014, with an emphasis on gender and time after appendectomy. Results A total of 2545 CD cases and 1134 UC cases were reported during a follow-up. Cox proportional hazards models with time-dependent variables allowed for the estimation of HRs and 95% CIs. Conclusions The risk of UC in young adults following appendectomy was not related to age at appendectomy, but it decreased as time elapsed post appendectomy.

Source link: https://doi.org/10.1136/bmjgast-2022-000925


Inflammatory bowel disease and immune-mediated inflammatory diseases: looking at the less frequent associations

Patients with inflammatory bowel disease have other immune-mediated inflammatory disorders, and any IMID rise in IBD patients is higher than in the general population. IBD and other IMIDs involve changes in innate and adaptive immune responses. IMIDs in IBD patients early detection is vital to avoid their deleterious medical course and minimize their psychological impact. Instead of treating each disease separately, IBD patients with IMIDs should be multispecialist, with a joint therapeutic approach rather than treating each disease separately.

Source link: https://doi.org/10.1177/17562848221115312

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions