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Indomethacin - Europe PMC

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Last Updated: 11 September 2022

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Protective effect of valerian extract capsule (VEC) on ethanol- and indomethacin-induced gastric mucosa injury and ameliorative effect of VEC on gastrointestinal motility disorder.

A Context Valerian extract capsule is a popular Chinese patent medicine used for digestive disorders. VEC clinical consequences in GI diseases are examined in detail by pharmacological studies. For three days in a row, Rats were orally administered VEC and teprenone. After 1 h, the five groups were orally given ethanol for 1 h or indomethacin for 7 hours, according to the spasmolytic activity of VEC on ACh/BaCl 2 -induced New Zealand rabbit smooth muscle contraction. The effects of VEC on intestinal motility in normal and neostigmine/adrenaline-induced mice were determined by a C57BL/6 mice carbon propelling test. VEC therapy improved the gastric lesion index and mucosal damage relative to the model group. Mucosal damage was reduced with relative to the model group. In normal and neostigmine/adrenaline-induced mice, ACh/BaCl 2's elevated tone and promoted intestinal transit. VEC demonstrated a potential gastroprotective effect, suggesting that VEC is a promising phytomedicine for the treatment of GI diseases.

Source link: https://europepmc.org/article/MED/35658820


Pentapeptide modified ethosomes for enhanced skin retention and topical efficacy activity of indomethacin.

Therefore, increasing these challenges will help to minimize the harmful and side effects caused by drug absorption into the systemic circulation and improve topical therapeutic drug's therapeutic efficacy. Pentapeptide is a skin peptide that can be identified and bound by signal detection elements, and it can be detected and bound by signal recognition proteins. Since the drug was loaded in the IMC-KTTKS-Es, the skin permeation increased, according to in vitro permeation studies. Skin retaining of IMC-KTTKS-Es has also improved skin durability, according to a Confocal laser scanning microscopy report. This report indicated that the IMC-KTTKS-Es might be a safe drug carrier for topical skin therapy with a high safety reputation.

Source link: https://europepmc.org/article/MED/35656937


Hyaluronan-modified transfersomes based hydrogel for enhanced transdermal delivery of indomethacin.

With the Franz diffusion cells, in vitro release and skin permeation experiments of IND-HTs/Gel were carried out. IND-HTs/Gel was found to have sustained drug release, as well as exceptional drug permeation and flux across the skin. HA improved the transdermal appearance by altering the microstructure of skin layers and decreasing skin barrier function, according to a hematoxylin-eosin stained. In addition, IND-HTs/Gel showed significant analgesic activity in a hot plate test as well as no potentially harmful skin irritations. The developed IND-HTs/Gel, according to this report, may be a promising alternative to traditional oral delivery of IND by topical administration.

Source link: https://europepmc.org/article/MED/35403516


Indomethacin: The Interplay between Structural Relaxation, Viscous Flow and Crystal Growth.

In order to determine the effects of particle size and heat transfer on the decomposition, crystal expansion, and decomposition kinetics of amorphous indomethacin, amorphous indomethacin were used in a non-isothermal differential scanning calorimetry experiment. During the total macroscopic amorphous-to-crystalline transition, the transition from zero-order to autocatalytic mechanism with increasing q+, the significant reduction of kinetics, storage below the glass transition temperature, and the rapid crystallization due to mechanically induced defects led to accelerated crystal growth kinetics. Whereas the stumbling q+ morph was discovered by a prolonged q+, a thermochemically stable u03b3 polymorph, with a fast q+ containing a significant amount of the metastable u03b1 polymorph. Based on the values of the respective activation energies, mutual correlations between the macroscopic and microscopic crystal growth processes, as well as between the viscous flow and structural relaxation motions, were investigated.

Source link: https://europepmc.org/article/MED/36080433


Therapeutic Versus Preventative Use of Ginkgo biloba Extract (EGb 761) against Indomethacin-Induced Gastric Ulcer in Mice.

The terpene lactones and flavonoid glycosides are two of the main bioactive components in the standardized Ginkgo biloba leaf extract, according to the standardized Ginkgo biloba leaf extract's main bioactive constituents. The antioxidant and anti-inflammatory capabilities of EGb 761 have also been demonstrated. This research was conducted to investigate the curative and preventative benefits of EGb 761 in experimentally-induced ulcers. Indomethacin was used orally by mice to cause gastric ulcers. EGb 761 was given by gavage for 7 days before and after the indomethacin administration. In gastric tissue homogenates, malondialdehyde, reduced glutathione, nitric oxide, and inflammatory cytokines were measured. It raised COX-2 and PCNA expression in stomach specimens, which was also present in saliva samples. Both prophylactic and therapeutic therapy, along with the lowering of COX-2 and PCNA expressions, resulted in significant decreases in ulcer lesions, nitrosative and oxidative damage, and inflammation markers. In addition, EGb 761 therapy was found to be more effective than prevention in the fight against stomach ulcers.

Source link: https://europepmc.org/article/MED/36080365


Protective effect of Anwulignan on gastric injury induced by indomethacin in mice.

In Schisandra sphenanthera fructus, Anwulignan is a monomer lignan. We investigated the protective role of AN against gastric injury caused by indomethacin in mice in mice and the associated mechanism of action in this research. The protective effect of AN on gastric ulceration of mice was mostly determined by monitoring gastric tissue morphology, gastric ulcer index, ulcer inhibition rate, gastric juice volume, and pH. AN decreased the gastric ulcer index, raised the ulcer inhibition rate, decreased the amount of gastric juice, and raised the pH value of the gastric juice, according to the study. Mouse indomethacin-induced gastric injury with indomethacin have been reduced by a significant decrease in the indomethacin-induced gastric injury, anti-inflammatory, and anti-apoptosis, leading to the fact that AN has a potential to be a drug or food supplement for gastric injury induced by indomethacin.

Source link: https://europepmc.org/article/MED/36041883


MRI Evaluation of Indomethacin Suppositories in the Prevention of Complications of Pancreatitis and Hyperamylasemia after Choledocholithiasis ERCP Based on Image Denoising Algorithm.

Objective After endoscopic retrograde cholangiopancreatography based on image denoising algorithm, it was determined that MRI analysis of indomethacin suppositories can aid in the prevention of pancreatitis and hyperamylasemia in patients with common bile duct calculi. Patients in group B were diagnosed with pancreatitis by conventional MRI and MRI with denoising technique, respectively, and the imaging characteristics and diagnosis rate differences between the two methods were discovered. The ROC curve was used to determine the diagnostic effectiveness of MRI denoising techniques for postoperative pancreatitis and serum amylase level measurements for hyperamylasemia. Conclusions The incidence of postoperative pancreatitis and hyperamylasemia in group B was significantly lower than that in group A. Although there was no significant difference in the diagnosis rate between the two methods, the number of cases of pancreatitis diagnosed by MRI based on denoising algorithms was marginally higher than that obtained by conventional MRI. The number of cases with pancreatic swelling, the number of cases of pancreatic duct/bile duct dilation, and the number of cases with abdominal effusion were all high compared to traditional MRI images. The area under the curve of MRI with denoising algorithm for the diagnosis of postoperative pancreatitis was 0. 855, and the sensitivity was 89. 40 percent.

Source link: https://europepmc.org/article/MED/36051000


Indomethacin prophylaxis in preterm infants: Changes over time.

Objective The aim of this study is to investigate how indomethacin prophylaxis use in the neonatal intensive care unit between 2008 and 2018. Cohort research of 19 715 infants born between 220/7-266/7 weeks' gestation, the first time in 213 NICUs, was 29. We investigated the prevalence of indomethacin prophylaxis by center and the association between indomethacin prophylaxis and significant intraventricular hemorrhage in 12 centers with the greatest relative increase in indomethacin prophylaxis prevalence. 50% of the 12 centers with the biggest relative increase in indomethacin prophylaxis prevalence found an inverse correlation between indomethacin prophylaxis prevalence and extreme intraventricular hemorrhage, while 50% showed a positive correlation.

Source link: https://europepmc.org/article/MED/35973793

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions