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Indomethacin - DOAJ

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Last Updated: 11 August 2022

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Anti-Ulcerogenic Potential of Aqueous Extract of Securinega virosa Leaf in Indomethacin-Induced Ulcerated Rats

In albino rats, the anti-ulcerogenic properties of Securinega virosa aqueous leaf extract on gastric ulcers caused by indomethacin were investigated. Thirty rats weighing 120-200 g were divided into six groups of five rats each. In the indomethacin administration's first oral doses of distilled water, cimetidine 60 mg kg-1, and the S. virosa extract, dosages of 35, 70, and 140 mg kg-1 b. w. Compared to the induced-untreated rats, the extract dramatically reduced gastric secretion, mean ulcer index, total acidity, total protein, and pepsin secretion. Catalase and SOD infections in the 35, 70, and 140 mg kg-1 bw S. virosa extract-treated groups were up soaring significantly over the untreated group. In the same way, the extract reversed the indomethacin-induced decrease in reduced glutathione level and the rise in malondialdehyde concentration in the serum. Indomethacin-induced ulcerative rats, it was discovered that the extract had anti-ulcerative and antioxidant activity.

Source link: https://doi.org/10.15835/nsb11210399


Review of characteristics and analytical methods for determination of indomethacin

The first choice of treatment for rheumatic disorders and other degenerative inflammatory diseases is nonsteroidal anti-inflammatory drugs. It is one of the most commonly used drugs in various clinical trials and therapies related to the mechanism of blocking prostaglandin production, reducing and eliminating many common inflammatory disorders in patients. INDO is identified as a separate active ingredient in a complete pharmaceutical formulation by routine pharmaceutical analysis using various chemical techniques.

Source link: https://doi.org/10.1515/revac-2022-0032


Indomethacin-induced oxidative stress enhances death receptor 5 signaling and sensitizes tumor cells to adoptive T-cell therapy

Background: Adoptive cell therapy with genetically modified T cells has developed into a promising treatment option for patients with cancer. paraphrasedoutput:Methods, a non-steroidal anti-inflammatory drug, is used to enhance the efficacy of ACT in a variety of preclinical studies. We reviewed the effects of indomethacin, a non-steroidal anti-inflammatory drug, on the effectiveness of ACT in a wide population. Donor T cells used in the ACT models were induced to express CD19CAR by a tumor-specific T cell receptor and T cells engineered to express CD19CAR. Indo's effects on donor T cell phenotype and function were investigated. Instead, indo-induced oxidative stress raised the expression of death receptor 5 in tumor cells, making them vulnerable to donor T cells that express TNF-related apoptosis-inducing ligand.

Source link: https://doi.org/10.1136/jitc-2022-004938


The Use of Indomethacin for Nocturnal Enuresis in Children With Nephrogenic Diabetes Insipidus: A Case Report and Review of the Literature

There are few published studies on the treatment of nocturnal enuresis in this population. Diagnosis: The brothers had primary nocturnal enuresis due to their elevated urine production from NDI. Interventions: We discuss a case of two brothers with NDI in whom indomethacin was added to their pharmacologic therapy specifically to treat enuresis. Teaching points: Nocturnal enuresis is a symptom of NDI that has unforeseen psychological consequences. In some patients, Indomethacin can cause nocturnal enuresis. Nonsteroidal anti-inflammatory drugs therapy can result in gastrointestinal and kidney side effects.

Source link: https://doi.org/10.1177/20543581221114693


The Effect of Caulerpa Cylindracea Extract on Histopathology Depiction of Male Rattus Norvegicus Gaster Mucosa Induced by Indomethacin

36 male Rattus norvegicus rats were divided into 4 groups, Group K, the untreated group, and Group P1 was stimulated by indomethacin 30 mg/kgBB and 2gr/100grBB of Caulerpa cylindracea extract per head, with indomethacin 30 mg/kgBB and indomethacin 30 mg/kgBB per head. In group K, there was only indomethacin and group P1 in terms of gastric mucosal harm, with Indomethacin and group P1 given Indomethacin and a 1gr/100grBB Caulerpa cylindracea extract. Given Indomethacin and Caulerpa cylindracea extract, there was a substantial difference between group K and group P2 that day. Group P1 and group P2 showed a significant difference between group P1 and group P2. There was a significant difference between group P1 and group P2. Conclusion: Giving Caulerpa cylindracea extract with 1 gr/100grBB dose and 2gr/100grBB dosage can restore mucosal damage in Rattus norvegicus male rats caused by indomethacin.

Source link: https://doi.org/10.33086/mhsj.v5i1.1671


Induction of leaky gut by repeated intramuscular injections of indomethacin to preweaning Holstein calves

ABSTRACT: This research was intended to establish a protocol for repeated intramuscular indomethacin injections to mimic leaky-gut-like symptoms in male Holstein calves, which were used to model and investigate the adverse effects of leaky gut on gut tissue function and inflammation response. In 18 male Holstein calves, a generalized random block layout was used to determine how repeated indomethacin intramuscular injections affected the development of leaky gut. Animals were enrolled at 3 u00b1 1 d of life, and after 21 d of adaptation, they were randomly assigned to one of three therapies consisting of intramuscular saline or indomethacin injections every 12 h for 48 hours of body mass, with high intramuscular indomethacin doses at 2. 4 mg/kg of BW and high intramuscular indomethacin dosed at 2. 4 mg/kg of body mass s In the case of lactulose and chromium-EDTA, the difference in marker concentrations between pre and post challenges was higher for INDO calves relative to CTL calves. In addition, chemokine ligand 2 and 4 and IL-6 were higher for INDO-H calves relative to CTL. Both doses of indomethacin resulted in decreases in villus length and surface area in the distal jejunum and ileum, as well as decreases in crypt depth and bread in the colon. The leaky gut challenge model described here may be used to increase understanding of intestinal disease pathogenesis in cattle and provide a safe alternative for testing intestinal health additives with intestinal health benefits.

Source link: https://doi.org/10.3168/jds.2021-21768

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions