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Hypothyroidism - Springer Nature

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Last Updated: 15 September 2022

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Relationship between the development of hyperlipidemia in hypothyroidism patients

Hypothyroidism is found to be closely linked to elevated plasma levels of total cholesterol, low-density lipoprotein cholesterol, triglyceride, and lower plasma levels of high density lipoprotein cholesterol, as shown in previous studies. The thyroid hormone, which has long been recognized as a key hormone secretly synthetized and released by the thyroid gland, has been shown to regulate plasma TC metabolism, although other studies have shown that the thyroid hormone also regulates plasma cholesterol metabolism independently of the TH, which promotes hyperlipidemia progression. HT-induced hyperlipidemia may be related to the down-regulated plasma levels of TH and the up-regulated plasma levels of TSH, according to several studies, indicating that HT can promote hyperlipidemia and its related cardiometabolic disorders.

Source link: https://doi.org/10.1007/s11033-022-07423-z


Severe neonatal hyperbilirubinemia secondary to combined RhC hemolytic disease, congenital hypothyroidism and large adrenal hematoma: a case report

Case study The 96 h of life, a full-term and vaginal delivery male infant with yellowish discoloration of body was transferred to our hospital. Both parents and the baby's blood types were O Rh, and direct coombu2019s test was negative. The father's blood type Rh was discovered by a minor blood group, indicating that he was ccDEEE, mather, and CcDEe for the baby. TSH was 13. 334 MIU/L on day 10, according to the thyroid hormone test. Potentiality was unleashed on day 7, which showed hearing loss. Conclusions Even if their parents' ABO blood test and Rh are consistent, a Coomb test is recommended for newborns with hyperbilirubinemia since they may have minor blood group incompatibilities. To determine whether there is adrenal hemorrhage, an abdominal ultrasound should be performed on newborns with palpable abdominal mass, anemia, and jaundice.

Source link: https://doi.org/10.1186/s12887-022-03594-7


Menorrhagia as main presentation sign of severe hypothyroidism in a pediatric patient: a case report

Background The relative high prevalence of menstrual irregularities in the first two- to-menarche years can raise the risk of misestimating related pathological conditions, which must always be thoroughly investigated with careful examination and anamnesis. Low plasma levels of thyroid hormone, according to it, may cause the hemostatic system to a hypocoagulable and hyperfibrinolytic state, leading to an elevated bleeding risk. Case presentation This case report details the case of a thirteen-year-old girl who complained of menorrhagia for the past fifteen days, resulting in severe anemia. The diagnosis of acute hypothyroidism in autoimmune thyroiditis with acquired von Willebrand syndrome and growth hormone deficiency was consistent across blood tests and thyroid ultrasound. Following normalization of coagulative parameters and pituitary hyperplasia, a substituted therapy with levothyroxine resulted in the absence of heavy bleeding after five days and three days.

Source link: https://doi.org/10.1186/s13052-022-01363-x


Stochastic epigenetic mutations as possible explanation for phenotypical discordance among twins with congenital hypothyroidism

Methods Ancestry was done on 23 twin pairs, 4 concordant, and 19 discordant pairs for CH at birth. The CH discordance of a monozygotic twin pair carrying a monoallelic nonsense mutation of DUOX2 did not show significant differences in methylation levels between CH cases and controls, but a change in methylation status of several genes may account for the CH discordance of a monozygotic twin pair carrying a monoallelic nonsense mutation of DUOX2 in a monoallelic nonsense mutation of DUOX2 remains unclear. The prioritization analysis for CH focused on the genes that were exclusively present in the cases that reported SLC26A4, FOXI1, NKX2-5, and TSHB as the genes with the highest score.

Source link: https://doi.org/10.1007/s40618-022-01915-2


Evaluating Statin Tolerability in Historically Intolerant Patients After Correcting for Subclinical Hypothyroidism and Vitamin D Insufficiency

Aim Our investigation, which sought to determine whether the move from a lipophilic statin to a water-soluble statin, or correction of subclinical hypothyroidism and/or vitamin D insufficiency/deficiency, raised statin tolerance, led to increased statin tolerance. We conducted a retrospective review of the patient records from our lipid clinic due to statin intolerance. After correction of the metabolic abnormality, patients with vitamin D insufficiency/deficiency/subthyroidism or hypothyroidism were re-challenged with a water-soluble statin. One or both metabolic abnormalities were present in 82 of these patients, with one or both metabolic abnormalities. With limited systemic exposure, 72% of eligible patients, defined as those with a diagnosed metabolic abnormality or no metabolic abnormality on a lipophilic statin, were able to tolerate a water-soluble statin or lipophilic statin. Conclusions Our results show that either suboptimisation/deficiency/deficiency/or vitamin D deficiency, or the switch from a lipophilic statin to a water-soluble statin improves statin tolerance.

Source link: https://doi.org/10.1007/s40292-022-00537-2


The association between hypothyroidism and proteinuria in patients with chronic kidney disease: a cross-sectional study

This research was designed to determine the relationship between proteinuria and hypothyroidism in chronic kidney disease patients. We conducted a cross-sectional research involving 421 CKD patients in a single hospital with results of 24-h urine protein excretion and thyroid function tests. Hypothyroidism prevalence was higher among participants with elevated CKD stage and nephrotic range proteinuria, according to a forensic range proteinuria review stratified by CKD stage and UP for hypothyroidism. Hypothyroidism is connected to decreased kidney function and nephrotic range proteinuria, not non-nephrotic proteinuria.

Source link: https://doi.org/10.1038/s41598-022-19226-0


Cancer-specific mortality in breast cancer patients with hypothyroidism: a UK population-based study

Hypothyroidism in breast cancer patients has risen significantly in hypothyroidism, possibly related to shared risk factors and breast cancer treatment, according to epidemiological studies. Methods We conducted a population-based survey using the Scottish Cancer Registry to identify women diagnosed with breast cancer between 2010 and 2017. Hypothyroidism diagnosed before and after breast cancer surgery and identified as having breast cancer-specific and all-cause mortality using hospital diagnoses and dispensed prescriptions for levothyroxine. Conclusions A total of 33,500 breast cancer patients were identified, of whom 3,802 had hypothyroidism before breast cancer diagnosis, and 565 patients went on to experience hypothyroidism after. We found no correlation between hypothyroidism and cancer-specific mortality in breast cancer patients. Conclusion In a large modern breast cancer population, there was no evidence that hypothyroidism, whether at diagnosis or diagnosed after breast cancer, was connected with cancer-specific or all-cause mortality.

Source link: https://doi.org/10.1007/s10549-022-06674-5


The role of miRNA-624-5p in congenital hypothyroidism and its molecular mechanism by targeting SIRT1

Accumulating evidence shows that congenital hypothyroidism is a form of endocrine disorders triggered by thyroid hormone imperfection. However, the exact functions and latent mechanism of microRNA-624-5p in CH remain unclear. In addition, the miR-624-5p and sirtuin1 levels in hippocampus or hippocampal neuronal cell nal cells were determined using quantitative real-time polymerase chain reaction or Western blot assays. Rat behaviours in Then CH were monitored using an open field test and a forced swim test. In hippocampus tissues of CH rats, miR-624-5p was up-regulated and SIRT1 was low-expressed, according to the qRT-PCR assay. MiR-624-5p inhibitors showably raised fT4 levels and reduced TSH levels in CH rats' plasma, as well as improved CH rat depressive behavior by targeting SIRT1. Moreover, our results showed that miR-624-5p inhibitor improved cell viability and reduced apoptotic neuronal cells, which was reversed by silencing SIRT1.

Source link: https://doi.org/10.1007/s13258-021-01171-3

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions